Protein Alignment eater and Stab2

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_038934443.1
• Gene: Stab2 / 282580
• RGDID: 628822
• Length: 2561
• Species: Rattus norvegicus
• Alignment Length: 1625
• Identity: 324/1625 - (19%)
• Similarity: 437/1625 - (26%)
• Gaps: 809/1625 - (49%)

  Fly    27 RNIK-GTA----VNVQTRDCCKGYKKVRSSALRC----LAQCKVNCGSGFC----TKPNVCTCKK 78
            ||:| |.|    |.|:...||||:  .......|    |..|.   |:|.|    .....|.|:.
  Rat   712 RNLKSGCARYCNVTVEIPRCCKGF--FGPDCTPCPGGFLTPCS---GNGQCMDGLAGNGTCICQD 771

  Fly    79 GY----VNLNNDPSNRCVPYCKG---CSRGTC----QSPGRCI---C---SARHLLDKTTNNCIP 126
            |:    ....:|| ||..|.|..   |..|||    .|.|.|:   |   :|....||.|:.|.|
  Rat   772 GFQGSMCQFCSDP-NRYGPRCNRTCLCVHGTCDNRLDSDGACLSGTCREGTAGRFCDKQTSACGP 835

  Fly   127 QCASGCPNGTCITPN---NCSCNKGYK--------------------LNPTTQVCLPT------- 161
            .......:.:|...|   :|.||:||:                    .:|..: |:.|
  Rat   836 YVQFCHIHASCEYSNKTASCVCNEGYEGDGVLCSKKDPCLGLTSRGGCSPNAE-CIQTSTGTYSC 899

  Fly   162 -CKD-------NCAAVNGFCAAP------------------NRCECNPGFIPKPKSKSFECQP-- 198
             |:.       :|..:|. |..|                  |.|||..||    :....:|:|
  Rat   900 VCQQGWTGNGRDCVGINN-CLLPSSGGCHDNATCLYVGPGQNECECKKGF----RGNGIDCEPII 959

  Fly   199 -------KCK-----NGCSNGVCRAPDKCECNKFYE----------------------------- 222
                   ||.     ...|:||.    .|.|.:.||
  Rat   960 SCLEQTEKCHPLATCQSTSSGVW----SCVCREGYEGNGVLCYGNVLMELSFLPEAAVFYQWINN 1020

  Fly   223 -----------------------KDID-------------------------------------- 226
                                   :|:|
  Rat  1021 ASLQSVLSTTSNLTVLVPSRRAFEDMDQNEKSFWLSRNNIPALIKYHILLGKYGVADLQALSSPH 1085

  Fly   227 -------GNCVPI----------------CENGCVNG---------------NCTAPDV---CQC 250
                   ||.:.:                .:|...||               ..:.|.:   .:.
  Rat  1086 MLATSLQGNFLQLDKADGNITIEGASIVDGDNAATNGVVHIINKVLVPQRGLTGSLPSLLTRLEQ 1150

  Fly   251 LTGYT-----KIGHNVCLAVCPEGCQNGVCVAPNECSCNAGYTKLEGVCTPVCKDGCVNGFCASP 310
            :.||:     .|.:|:..|:  |.........||. .....|.: |...|.: |:..:.......
  Rat  1151 MPGYSIFRGYIIHYNLASAI--EAADAYTVFVPNN-EAIENYIR-EKKATSL-KEDILRYHVVLG 1210

  Fly   311 EKCSCND----------------------------------------------GYEMDSE---NR 326
            ||...||                                              |.|...|   ||
  Rat  1211 EKLLKNDLHNGMHRETMLGFSYLLAFFLRNDQLYVNEAPINYTNVATDKGVIHGLEKVLEIQKNR 1275

  Fly   327 C----SPVCSGGCKNGFCVAPGKCSCDEGYIKGTGN---------------SCKPIC-----SKG 367
            |    :.:..|.|  |.|.....|..:...::.|..               .|:|.|     ::.
  Rat  1276 CDNNDTIIVRGEC--GKCSQQAPCPLETKPLRETRKCIYSIYFMGKRSVFIGCQPQCVRTIITRA 1338

  Fly   368 CENGFCDAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCV----APGKCSCDEGYSKETGNSCKP 428
            |..||. .|: |....|   .|:|    ||||   ||||:    ..|.|.|..|:|   |.:|:
  Rat  1339 CCAGFF-GPQ-CQACPG---RGQN----VCSG---NGFCLDGVNGTGTCQCGLGFS---GTACE- 1387

  Fly   429 ICSKGCENGFCDAPEKCSCNDGYEMDSENRCS--PVCSGGCK-------------------NGFC 472
            .|::|.....||  :.|||..|       |||  |:..|.|.                   ||.|
  Rat  1388 TCTEGKYGIHCD--QACSCVHG-------RCSQGPLGDGSCDCDVGWRGVKCDMEITTDNCNGTC 1443

  Fly   473 -------VAP-GK--CSCDEGYSKETGNSCKPICSKGCE--NGFCDAPEKCS----------CND 515
                   :.| ||  |.|..|: :..|..|..|  ..||  ||.|.....|.          |..
  Rat  1444 HTSANCLLDPDGKASCKCAAGF-RGNGTVCTAI--NACETSNGGCSTKADCKRTTPGNRVCVCKA 1505

  Fly   516 GYEMDG----------ENRCSPVCSGGC-KNGFC--VAPEK--CSCDEGYSKETGNSCKPICS-- 563
            ||..||          ||.      ||| :|..|  ..|.:  |:|   ..|.||:.  .:||
  Rat  1506 GYTGDGIVCLEINPCLENH------GGCDRNAECTQTGPNQAVCNC---LPKYTGDG--KVCSLI 1559

  Fly   564 NGC--ENG------FCDAPEK----CSCNDGYEMDGENRCSPVCSG------------------- 597
            |.|  .||      ||:..|:    |:|...|..||     .||.|
  Rat  1560 NVCLTNNGGCSPFAFCNYTEQDQRICTCKPDYTGDG-----IVCRGSIYGELPKNPSTSQYFFQL 1619

  Fly   598 ------------------------------------------------GCK-------------- 600
                                                            ||:
  Rat  1620 QEHAVRELAGPGPFTVFAPLSSSFNHEPRIKDWDQQGLMSQVLRYHVVGCQQLLLDNLKVTTSAT 1684

  Fly   601 --------------------------------NG-------------FCVAP----GK------- 609
                                            ||             ..:.|    |:
  Rat  1685 TLQGEPVSISVSQDTVFINNEAKVLSSDIISTNGVIHVIDKLLSPKNLLITPKDALGRVLQNLTT 1749

  Fly   610 CSCDEGYSK-------------ETGNSCKPIC--------------------------------- 628
            .:.:.||:|             .|.:...|:.
  Rat  1750 VAANHGYTKFSKLIQDSGLLSVITDSIHTPVTVFWPTDKALEALPPEQQDFLFNQDNKDKLKSYL 1814

  Fly   629 -------SKGCENGFCDAPEKCS------------CNDGYEMD----SENRC------------- 657
                   ||...:   |.|...|            |..|.::.    :|..|
  Rat  1815 KFHVIRDSKALAS---DLPRSASWKTLQGSELSVRCGTGSDIGELFLNEQMCRIIQRGLLFDVGV 1876

  Fly   658 ---------SPVCSGGCKN----------GFCIAPGKCSCDEGYSKETGNSCKPICS-------- 695
                     .|...|.|..          |.||...:|...   ||..|...|.|.:
  Rat  1877 AYGIDCLLMDPTLGGRCDTFTTFDIPGECGSCIFTPRCPLK---SKPKGVKKKCIYNPLPFRRNV 1938

  Fly   696 KGCENGFC----DAPEKCSCNDGYEMDSENRCSPVCSGG----CKN-GFC----VAPGKCSCDEG 747
            :||:| .|    ..|.   |..||.|..   |. .|.||    |.| |.|    ...|:|.|..|
  Rat  1939 EGCQN-LCTLVIQTPR---CCHGYFMPD---CQ-ACPGGPDTPCNNRGMCRDLYTPMGQCLCHTG 1995

  Fly   748 YSKETGNSCKPICSKGCENGFCEAPEKCSCNDGYEMDGENRCSPVCSGGCKNGFCIAPGKCSCDE 812
            ::   |.:|: :|..|.....|   :.|||::              .|.|..|. ...|:|.|:.
  Rat  1996 FN---GTACE-LCWHGRFGPDC---QPCSCSE--------------HGQCDEGI-TGSGECLCET 2038

  Fly   813 GYSRETGNSCK------PICSKGCE-NGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCK--NGFC 868
            |:   ||..|.      |:|:..|. :..|.....|.||..||.|... |:.|  ..||  ||.|
  Rat  2039 GW---TGRFCDTPTAVIPVCTPVCSVHATCTENNTCVCNLNYEGDGLT-CTVV--DFCKQNNGGC 2097

  Fly   869 VAPGKCSCDEGYSKETEISCAPFCKDGCVNGLCVSPDFCKCDDGYIFVEESKSC-QLDKELLGDY 932
            ....|||     .|.|::||:  ||.|...            |||       || ::|....|..
  Rat  2098 AKVAKCS-----QKGTQVSCS--CKKGYKG------------DGY-------SCIEIDPCADGVN 2136

  Fly   933 SDCDKN--CRNGTCVEGICTCSKQYKLHRNEDDNNLICLPICEPE------CL--NGLCEFPGSC 987
            ..|.::  ||.....:..|.|...| :....|         ||||      ||  ||.|....||
  Rat  2137 GGCHEHATCRMTGPGKHKCECKSHY-VGDGVD---------CEPEQLPLDRCLQDNGQCHPDASC 2191

  Fly   988  987
              Rat  2192  2191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Stab2	XP_038934443.1	EGF_3	254..283	CDD:463759
		EGF_3	334..369	CDD:463759
		Fasciclin	390..512	CDD:396845
		FAS1	511..658	CDD:441906
		EGF_3	840..868	CDD:463759	7/27 (26%)
		EGF_3	881..912	CDD:463759	4/31 (13%)
		EGF_3	923..955	CDD:463759	6/35 (17%)
		EGF_3	961..997	CDD:463759	9/39 (23%)
		Fasciclin	1014..1133	CDD:396845	7/118 (6%)
		Fasciclin	1152..1269	CDD:396845	18/121 (15%)
		EGF_3	1478..1514	CDD:463759	11/35 (31%)
		EGF_3	1520..1556	CDD:463759	13/46 (28%)
		EGF_3	1562..1598	CDD:463759	11/40 (28%)
		Fasciclin	1629..1729	CDD:396845	4/99 (4%)
		Fasciclin	1754..1885	CDD:396845	14/133 (11%)
		EGF_3	2059..2084	CDD:463759	8/25 (32%)
		EGF_3	2090..2125	CDD:463759	18/60 (30%)
		EGF_3	2131..2168	CDD:463759	8/46 (17%)
		Link_Domain	2202..2294	CDD:470631
		FAS1	2360..2449	CDD:214719