Protein Alignment eater and STAB1

DIOPT Version :9

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_016861487.1
• Gene: STAB1 / 23166
• HGNCID: 18628
• Length: 2615
• Species: Homo sapiens
• Alignment Length: 1237
• Identity: 263/1237 - (21%)
• Similarity: 377/1237 - (30%)
• Gaps: 522/1237 - (42%)

  Fly   104 QSPGRCICSARHLLDKTTNNCIPQCASGCPNGTCITPNNCS----CNKGYKLNPTTQVCLPTCKD 164
            ::|||.:.....:|...::.|:...|... ...|:   ||:    |.:|::|..|.       :.
Human  1240 EAPGRSLIGLSGVLTVGSSRCLHSHAEAL-REKCV---NCTRRFRCTQGFQLQDTP-------RK 1293

  Fly   165 NCAAVNGF---------CAAPNRC-ECNPGFIPKPKSKSFECQPKCKNG----CS-NGVCR---- 210
            :|...:||         ||...:. :|.|||.      ...|:| |..|    || :|.|:
Human  1294 SCVYRSGFSFSRGCSYTCAKKIQVPDCCPGFF------GTLCEP-CPGGLGGVCSGHGQCQDRFL 1351

  Fly   211 APDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPDVCQCLTGYTKIGHNVCLAVCPEGCQ-NGV 274
            ...:|.|::.:.    |....:||.|....|||.  ||.|..|           :|.||.| :|.
Human  1352 GSGECHCHEGFH----GTACEVCELGRYGPNCTG--VCDCAHG-----------LCQEGLQGDGS 1399

  Fly   275 CVAPNECSCNAGYTKL---EGVCTPVCKDGC-VNGFC----ASPEKCSCNDGYEMDSENR--CSP 329
            ||      ||.|:..|   :.:.:|.|...| .|..|    |....|:|..||   |.|.  ||.
Human  1400 CV------CNVGWQGLRCDQKITSPQCPRKCDPNANCVQDSAGASTCACAAGY---SGNGIFCSE 1455

  Fly   330 V--CS---GGCK---NGFCVAPGK--CSCDEGYIKGTGNSCKPICSKGCENGFC--------DAP 376
            |  |:   |||.   |...||||:  |:|.:||: |.|..|:.|.|....:|.|        ..|
Human  1456 VDPCAHGHGGCSPHANCTKVAPGQRTCTCQDGYM-GDGELCQEINSCLIHHGGCHIHAECIPTGP 1519

  Fly   377 EK--CSCNDGYEMDGENRCSPV--CS---GGCK-NGFCVAPG----KCSCDEGYSKETGNSCK-- 427
            ::  |||.:||..||...|..:  ||   |||. ...|.:.|    .|:||..::...|.:|:
Human  1520 QQVSCSCREGYSGDGIRTCELLDPCSKNNGGCSPYATCKSTGDGQRTCTCDTAHTVGDGLTCRAR 1584

  Fly   428 ----------------------------PICS--------------------------------- 431
                                        |..|
Human  1585 VGLELLRDKHASFFSLRLLEIHGRLRLLPFHSCCCCLPQEYKELKGDGPFTIFVPHADLMSNLSQ 1649

  Fly   432 ------------------KGC---------ENGFCDA----PEKCSCNDG--------------- 450
                              .||         |.|:..|    |.:.|..:|
Human  1650 DELARIRAHRQLVFRYHVVGCRRLRSEDLLEQGYATALSGHPLRFSEREGSIYLNDFARVVSSDH 1714

  Fly   451 ---------------------YEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETG----N 490
                                 :|.|.    :|:..   :|....|.|     .||...:|    .
Human  1715 EAVNGILHFIDRVLLPPEALHWEPDD----APIPR---RNVTAAAQG-----FGYKIFSGLLKVA 1767

  Fly   491 SCKPICSKGCENGF-----CDAPEKCSCNDG----YEMDGENRCSPVCSGG-CKNGFCVA----- 540
            ...|:..:.....|     .||..:....|.    |..|..::.:.:..|. .:|...:|
Human  1768 GLLPLLREASHRPFTMLWPTDAAFRALPPDRQAWLYHEDHRDKLAAILRGHMIRNVEALASDLPN 1832

  Fly   541 ----------PEKCSCDEGYSKE---------------------------------TGNSC---- 558
                      |...||....:.|                                 .|..|
Human  1833 LGPLRTMHGTPISFSCSRTRAGELMVGEDDARIVQRHLPFEGGLAYGIDQLLEPPGLGARCDHFE 1897

  Fly   559 -KPICSNGCENGFCDAPEKCSCNDGYEMDGE-NRC----------SPVCSGGCKNGFCVAPGKCS 611
             :|:..|.|.....:.|    |.:|.:..|. ..|          .|:.|.|.::.: |.|....
Human  1898 TRPLRLNTCSICGLEPP----CPEGSQEQGSPEACWRFYPKFWTSPPLHSLGLRSVW-VHPSLWG 1957

  Fly   612 CDEGYSKETGNSC-----KPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCS--GGCKNGF 669
            ..:|..:....:|     ||.|..|.....|.|     |..|       ..|| ||  |.|.:|.
Human  1958 RPQGLGRGCHRNCVTTTWKPSCCPGHYGSECQA-----CPGG-------PSSP-CSDRGVCMDGM 2009

  Fly   670 CIAPGKCSCDEGYSKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNG 734
            . ..|:|.|..|::   |.:|: :|:.|.....|.|   |.|.      ...||.....|.
Human  2010 S-GSGQCLCRSGFA---GTACE-LCAPGAFGPHCQA---CRCT------VHGRCDEGLGGS---- 2056

  Fly   735 FCVAPGKCSCDEGYSKETGNSC------KPICSKGC-ENGFCEAPEKCSCNDGYEMDGENRCSPV 792
                 |.|.||||:   ||..|      :|:|:..| ....|.|...|.|:.|||.||.     |
Human  2057 -----GSCFCDEGW---TGPRCEVQLELQPVCTPPCAPEAVCRAGNSCECSLGYEGDGR-----V 2108

  Fly   793 CSGG--CKNGFCIAPGKCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSC-----NDGYEMD 850
            |:..  |::|.    |.||       |..|     ||:      ......|:|     .||:...
Human  2109 CTVADLCQDGH----GGCS-------EHAN-----CSQ------VGTMVTCTCLPDYEGDGWSCR 2151

  Fly   851 SENRCSPVCSGGC-KNGFCVAPG----KCSCDEGYSKE----TEISCAPFCKDGCVNGLCVSPDF 906
            :.|.|:....||| ::..|::.|    :|.|..||..:    .|.|..|.  |.|:.    .|..
Human  2152 ARNPCTDGHRGGCSEHANCLSTGLNTRRCECHAGYVGDGLQCLEESEPPV--DRCLG----QPPP 2210

  Fly   907 C----KCDD--------------------GYIFVEESKSCQLDKELLGDY--------------- 932
            |    .|.|                    |..|.|...:|:....:|..:
Human  2211 CHSDAMCTDLHFQEKRAGVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCL 2275

  Fly   933 -----------------SDCD------------KN------------------CRNGTCVEGICT 950
                             :||.            ||                  ||||...:||.|
Human  2276 MGWLANGSTAHPVVFPVADCGNGRVGIVSLGARKNLSERWDAYCFRVQDVACRCRNGFVGDGIST 2340

  Fly   951 CS 952
            |:
Human  2341 CN 2342

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810