DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and Megf6

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001156449.1	Gene:	Megf6 / 230971	MGIID:	1919351	Length:	1572	Species:	Mus musculus

Alignment Length:	1434	Identity:	358/1434 - (24%)
Similarity:	468/1434 - (32%)	Gaps:	521/1434 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RNIKGTAVNVQTRDCCKGY--KKVRSSALRCLAQCKVNCGSGFCTKP--NV-----CTCKKGYVN 82
            |.:..|......| ||.|:  |..:...|..:.:| .|...| |..|  |.     |.|..|| .
Mouse    93 RQVYATEARTVFR-CCPGWSQKPGQEGCLSDVDEC-ANANGG-CEGPCCNTVGGFYCRCPPGY-Q 153

  Fly    83 LNNDPS-----NRCVPYCKGCSRGTCQSPGRCICSAR-----HLLDKTTNNCIPQCASGCPNGTC 137
            |..|..     :.|..:..||......:||..:|..:     | .|..|...|..|..|  ||.|
Mouse   154 LQGDGKTCQDVDECRSHNGGCQHRCVNTPGSYLCECKPGFRLH-TDGRTCLAISSCTLG--NGGC 215

  Fly   138 --------ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFC-------AAPNRCECNPGFIP 187
                    :|.:.|.|...|:|....:.|:.  :..||..||.|       .....|.|:||:..
Mouse   216 QHQCVQLTVTQHRCQCRPQYQLQEDGRRCVR--RSPCADGNGGCMHTCQELRGLAHCGCHPGYQL 278

  Fly   188 KPKSKSF----ECQ---PKCKNGCSNGVCRAPDKCECNKFYEKDIDG-NCVPI-------CENGC 237
            ....|:.    ||.   .:|.:||.|  .:...||.|:..||...|| .|..|       ||.|
Mouse   279 AADRKACEDVDECALGLAQCAHGCLN--TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEAG- 340

  Fly   238 VNGNC--------TAPDVCQCLTGY-TKIGHNVCLAVCPEGCQNGVC---VAPN-----ECSCNA 285
             ||.|        |.| :|.|..|| .......|:.:  :.|.|..|   |..|     ||||.|
Mouse   341 -NGGCSHGCSHTSTGP-LCTCPRGYELDEDQKTCIDI--DDCANSPCCQQVCANTPGGYECSCFA 401

  Fly   286 GYTKLEGVCTPVCKDGCVNGFCASPEKCS---------CNDGYEMDSENR-CSPV---------- 330
            ||......|.....|.|.:|.......||         |..||.:|.:.| |:|:
Mouse   402 GYRLNTDGCGCEDVDECASGHSGCEHHCSNLAGSFQCFCEAGYRLDEDRRGCTPLEESVVDLDGQ 466

  Fly   331 -------------------------------------------------------CS---GGCKN 337
                                                                   ||   ..|:|
Mouse   467 LPFVRPLPHIAVLGDELPQLFQDDYGAEEEAVAELRGEHTLTEKFVCLDHSFGHDCSLTCDDCRN 531

  Fly   338 GFCVAPG--KCSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDGYEMD---GENRCSPVC 397
            |....||  .|.|.||:   ||..|...|........|.:|  |.|.:|...|   |..||.|..
Mouse   532 GGTCFPGLDGCDCPEGW---TGIICNETCPPDTFGKNCSSP--CICQNGGTCDPVSGACRCPPGV 591

  Fly   398 SG-----GCKNGF----------CVAPGKCS-------CDEG-YSKETGNSCKPI-----CSKGC 434
            ||     ||..||          |...|:|.       ||.| |.:....:|.|.     ||:.|
Mouse   592 SGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRLYGACLCDPGLYGRFCHLACPPWAFGPGCSEDC 656

  Fly   435 -----ENGFCDAPE-KCSCNDGY-----EMDSE---------NRCS------------------- 460
                 ....|::.: .|||..|:     |.:.|         |||:
Mouse   657 LCEQSHTRSCNSKDGSCSCKAGFQGERCEAECEPGSFGPGCRNRCTCRPGVACDPVSGECRTQCP 721

  Fly   461 ------------PV------CSGGCKNGFCV-AP-----GKCSCDEGYSKETGNSCKPICSKG-- 499
                        ||      |||.|.   || ||     |:|.|..|   :||..|...|.:|
Mouse   722 PGYQGEDCGQECPVGTFGVNCSGSCS---CVGAPCHRVTGECLCPPG---KTGEDCGADCPEGRW 780

  Fly   500 ----------CENG-FCDAPE--KCSCNDGYEMDGENRCSPVCSGG-----------CKN-GFC- 538
                      ||:| .|| ||  .|.|..|:.   .:||...|..|           |.| |.|
Mouse   781 GLGCQEICPACEHGASCD-PETGTCLCLPGFV---GSRCQDACPAGWFGTGCQMRCACANDGHCH 841

  Fly   539 VAPEKCSCDEGYSKETGNSCKPICSNG-----------CE--NGFCDAPE-KCSCNDGYEMDGEN 589
            .|..:|||..|:   ||.||:..|.:|           |.  :|.|||.. .|.|..|||
Mouse   842 PATGRCSCAPGW---TGLSCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAGYE----- 898

  Fly   590 RCSPVCSGGCKNGFCVAPG---KCSCDEGYS-KETGNSCK-------PICSKGCENGF--CDAPE 641
              .|.|...|:.|: ..||   ||.|:.|.: .....:|.       ..|...|..||  .|...
Mouse   899 --GPQCEQWCRQGY-FGPGCEQKCRCEHGATCDHVSGACTCPAGWRGSFCEHACPAGFFGLDCGS 960

  Fly   642 KCSCNDGYEMDSEN-------------------------RCSPVCSGGCKNGFCIAP--GKCSCD 679
            .|:|:.|...|:..                         .||.:|:  |.||....|  |:|.|.
Mouse   961 ACNCSAGAPCDAVTGSCICPAGRWGPHCAQTCPPLTFGLNCSQICT--CFNGASCDPVLGQCHCA 1023

  Fly   680 EGYSKET----------GNSCKPICSKGCEN-GFCDAP--EKCSCNDGYE-MDSENRCSPVCSG- 729
            .|:...|          |.:|:..|.  |.| |.|| |  .:|:|.:|:. :..||.|.|...|
Mouse  1024 PGWMGPTCLQACPAGLYGKNCQHSCL--CRNGGNCD-PILGQCTCPEGWTGLACENECLPGHHGA 1085

  Fly   730 GCK-NGFCV-------APGKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDG---YEM 783
            ||: |..|:       ..|.|.|..|:   ||:.|:..|..|.....||  |.|:|..|   :.:
Mouse  1086 GCRLNCSCLNGGTCDRLTGHCRCPTGW---TGDKCQSPCVSGMFGVHCE--EHCACRKGATCHHV 1145

  Fly   784 DGENRCSP-----VCSGGCKNGF--------CIAP---------GKCSCDEGYSRETGNSCKPIC 826
            .|...|.|     .|...|..|:        |..|         |:|.|..|:   ||..|:..|
Mouse  1146 TGACLCPPGWRGSHCEQACPRGWFGEACAQRCHCPPGASCHHVSGECHCPPGF---TGPGCEQAC 1207

  Fly   827 SKG-----CENGFCDAPEK----------CSCNDGYE-MDSENRC-----SPVCSGGCK---NGF 867
            ..|     ||:. |..|.:          |.|..||. .|.:.||     .|.|...||   .|.
Mouse  1208 QPGTFGKDCEHP-CQCPGETWACHPASGACVCAAGYHGTDCQQRCPSGRYGPGCEQICKCLNGGT 1271

  Fly   868 C-VAPGKCSCDEGY-SKETEISC-----APFCKDGC----------VNGLCVSP----------- 904
            | .|.|.|.|..|: ..:..::|     .|.|...|          |:|.|:.|
Mouse  1272 CDPATGACYCPAGFLGADCSLACPQGRFGPSCAHVCTCGQGAACDPVSGTCICPPGKTGGHCERG 1336

  Fly   905 -----------DFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNC----------------RNG 942
                       ..|.|.:|.:....:.||......:|.:  |:..|                .||
Mouse  1337 CPQDRFGKGCEHKCACRNGGLCHATNGSCSCPLGWMGPH--CEHACPAGRYGAACLLECSCQNNG 1399

  Fly   943 TC--VEGICTCSKQYKLHRNEDD-----NNLICLPICEPECLNGL-CE-FPGSCVCWDGESPIDG 998
            :|  ..|.|.|...:.....||.     :...|..:|  ||..|. |: ..|.|:|..|   ..|
Mouse  1400 SCEPTSGACLCGPGFYGQACEDTCPAGFHGSGCQRVC--ECQQGAPCDPVSGRCLCPAG---FHG 1459

  Fly   999 YSCQ 1002
            ..|:
Mouse  1460 QFCE 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Megf6	NP_001156449.1	EMI	42..111	CDD:284877	6/18 (33%)
		FXa_inhibition	126..161	CDD:291342	12/37 (32%)
		vWFA	<153..201	CDD:294047	10/48 (21%)
		vWFA	<236..284	CDD:294047	11/49 (22%)
		vWFA	<283..324	CDD:294047	13/42 (31%)
		FXa_inhibition	337..372	CDD:291342	12/37 (32%)
		vWFA	<370..409	CDD:294047	13/40 (33%)
		vWFA	<412..451	CDD:294047	9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900