DRSC/TRiP Functional Genomics Resources

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Protein Alignment eater and MEGF6

DIOPT Version :9

Sequence 1:NP_651533.3 Gene:eater / 43262 FlyBaseID:FBgn0243514 Length:1074 Species:Drosophila melanogaster
Sequence 2:XP_011539187.1 Gene:MEGF6 / 1953 HGNCID:3232 Length:1603 Species:Homo sapiens


Alignment Length:1377 Identity:354/1377 - (25%)
Similarity:455/1377 - (33%) Gaps:497/1377 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 GYKKVRSSALRCLAQC--------------KVNCGSGFC----------TKPNVCTCKKGYVNLN 84
            ||::|.::..|.:.:|              ...|.:..|          .:|  |.|..|:    
Human   157 GYRQVYTTEARTVLRCCRGWMQQPDEEGCLSAECSASLCFHGGRCVPGSAQP--CHCPPGF---- 215

  Fly    85 NDPSNRC---VPYCK----GCSRGTCQSPGRCICSAR-----HLLDKTTNNCIPQCASGCPNGTC 137
              ...||   |..|:    ||......:||..:|..:     | .|..|...|..||.|  ||.|
Human   216 --QGPRCQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLH-TDSRTCLAINSCALG--NGGC 275

  Fly   138 --------ITPNNCSCNKGYKLNPTTQVCL---------PTCKDNCAAVNGFCAAPNRCECNPGF 185
                    ||.:.|.|..|::|....:.|:         .:|...|..|.|..    ||||:.|:
Human   276 QHHCVQLTITRHRCQCRPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLA----RCECHVGY 336

  Fly   186 IPKPKSKSF----ECQ---PKCKNGCSNGVCRAPDKCECNKFYEKDIDG-NCVPI-------CE- 234
            ......|:.    ||.   .:|.:||.|  .:...||.|:..||...|| .|..|       || 
Human   337 QLAADGKACEDVDECAAGLAQCAHGCLN--TQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEA 399

  Fly   235 --NGCVNG--NCTAPDVCQCLTGY-TKIGHNVCLAV--------CPEGCQNGVCVAPN--ECSCN 284
              .||.:|  :.:|..:|.|..|| .......|:.|        |.:.|.|.    |.  ||.|.
Human   400 NNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNN----PGGYECGCY 460

  Fly   285 AGY-TKLEGV-CTPV---------CKDGCVNGFCASPEKCSCNDGYEMDSENR-CSPV------- 330
            ||| ...:|. |..|         |:..|.|  .|...:|||..||.:..:.| |||:       
Human   461 AGYRLSADGCGCEDVDECASSRGGCEHHCTN--LAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDL 523

  Fly   331 ----------------------------------------------------------CS---GG 334
                                                                      ||   ..
Human   524 DGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDD 588

  Fly   335 CKNGFCVAPG--KCSCDEGYIKGTGNSCKPIC-----SKGCENGFCDAPEKCSCNDGYEMD---G 389
            |:||.....|  .|.|.||:   ||..|...|     .|.|.       ..|||.:|...|   |
Human   589 CRNGGTCLLGLDGCDCPEGW---TGLICNETCPPDTFGKNCS-------FSCSCQNGGTCDSVTG 643

  Fly   390 ENRCSPVCSG-----GCKNGF----------CVAPGKCS-------CDEG-YSKETGNSCKP--- 428
            ..||.|..||     ||..|:          |...|:|.       ||.| |.:....:|.|   
Human   644 ACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAF 708

  Fly   429 ----------------ICSK-----GCENGF----CDAP-----------EKCSCNDGYEMDSEN 457
                            .|.|     .|:.||    |.|.           :.|:|..|...||.:
Human   709 GPGCSEECQCVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVS 773

  Fly   458 -----RC------------SPV------CSGGCKNGFCVAP-----GKCSCDEGYSKETGNSCKP 494
                 ||            .||      ||..|..|  .||     |:|.|..|   .||..|:.
Human   774 GECGKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCG--GAPCHGVTGQCRCPPG---RTGEDCEA 833

  Fly   495 ICSKG------------CENGF-CDAPE--KCSCNDGYEMDGENRCSPVCSGG-----------C 533
            .|.:|            |::.. || ||  .|.|..|:.   .:||..||..|           |
Human   834 DCPEGRWGLGCQEICPACQHAARCD-PETGACLCLPGFV---GSRCQDVCPAGWYGPSCQTRCSC 894

  Fly   534 KN-GFC-VAPEKCSCDEGYSKETGNSCK---------PICSNGCE----NGFCDA-PEKCSCNDG 582
            .| |.| .|...|||..|:   ||.||:         |.||:.|.    :|.||| ...|.|..|
Human   895 ANDGHCHPATGHCSCAPGW---TGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAG 956

  Fly   583 YEMDGENRCSPVCSGGCKNGFCVAPG---KCSCDEGYS-KETGNSCK-------PICSKGCENGF 636
            |       ..|.|...|..|. ..||   :|.|..|.: .....:|.       ..|...|..||
Human   957 Y-------VGPRCEQQCPQGH-FGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGF 1013

  Fly   637 --CDAPEKCSCNDGYEMDSEN------------RCSPVCSG-----------GCKNGFCIAP--G 674
              .|....|:|..|...|:.|            ||:..|..           .|.||....|  |
Human  1014 FGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHG 1078

  Fly   675 KCSCDEGYSKETGNSCKPICSKG-----------CEN-GFCD-APEKCSCNDGYE-MDSENRCSP 725
            :|.|..|:   .|.||...|..|           |:| |.|| ....|:|.:|:. :..|..|.|
Human  1079 QCHCAPGW---MGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLP 1140

  Fly   726 -----VC--SGGCKNGFCVAP--GKCSCDEGYSKETGNSCKPICSKGCENGFCEAPEKCSCNDG- 780
                 .|  ||||.||....|  |:|.|..|:   ||:.|:..|.:|.....|  .::|||..| 
Human  1141 RDVRAGCRHSGGCLNGGLCDPHTGRCLCPAGW---TGDKCQSPCLRGWFGEAC--AQRCSCPPGA 1200

  Fly   781 --YEMDGENRCSPVCSG-GCKNGFCIAPGKCSCDEGYSRETGNSCKPICSKGCENGFC-DAPEKC 841
              :.:.|..||.|..:| ||:.         :|..|   ..|..|..:|....||..| .|...|
Human  1201 ACHHVTGACRCPPGFTGSGCEQ---------ACPPG---SFGEDCAQMCQCPGENPACHPATGTC 1253

  Fly   842 SCNDGYEMDS-ENRCSP---------VCSGGCKN-GFC-VAPGKCSCDEGY-SKETEISC----- 888
            ||..||...| :.||.|         :|  ||.| |.| .|.|.|.|..|: ..:..::|     
Human  1254 SCAAGYHGPSCQQRCPPGRYGPGCEQLC--GCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRF 1316

  Fly   889 APFCKD--GCVNGLCVSP--DFCKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRN-GTC--VE 946
            .|.|..  ||..|....|  ..|.|..|...|...:.|..::..:|....|  :||| |.|  ..
Human  1317 GPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTC--SCRNGGLCHASN 1379

  Fly   947 GICTCSKQYKLHRNEDDNNLICLP-----ICEPECL---NGLCE-FPGSCVCWDG------ESP- 995
            |.|:|...:.....|    |.|.|     .|..||.   |..|| ..|:|.|..|      |.| 
Human  1380 GSCSCGLGWTGRHCE----LACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPC 1440

  Fly   996 ---IDGYSCQSM 1004
               ..|..||.:
Human  1441 PPGFHGAGCQGL 1452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eaterNP_651533.3 None
MEGF6XP_011539187.1 EMI 108..176 CDD:284877 5/18 (28%)
vWFA <215..261 CDD:294047 11/52 (21%)
FXa_inhibition 268..304 CDD:291342 12/37 (32%)
vWFA <342..384 CDD:294047 13/43 (30%)
FXa_inhibition 397..432 CDD:291342 10/34 (29%)
vWFA <432..469 CDD:294047 12/40 (30%)
vWFA <472..511 CDD:294047 11/40 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1218
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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