DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and Stab2

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_619614.1	Gene:	Stab2 / 192188	MGIID:	2178743	Length:	2559	Species:	Mus musculus

Alignment Length:	1657	Identity:	336/1657 - (20%)
Similarity:	463/1657 - (27%)	Gaps:	766/1657 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YSLLLGLVSAQIC--TVNVTRNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKVN----CGSG- 66
            ::|.:|  .|:.|  ||.:.|..|| ........|..|:....|...:|:.....|    |..|
Mouse   716 WNLKIG--CARYCDVTVEIPRCCKG-FFGPDCNPCPGGFMNPCSGNGQCIDGLGGNGTCICEDGF 777

  Fly    67 ------FCTKPN--------VCTCKKGYVN--LNNDPS-------------------NRCVPYCK 96
                  ||:|||        .|.|..|..:  |::|.|                   :.|.||.:
Mouse   778 QGSRCQFCSKPNRYGPQCNRTCQCVHGICDNRLDSDGSCLPGTCREGTAGRFCDKQTSACGPYMQ 842

  Fly    97 GCS-RGTCQ---SPGRCICSARHLLDKT----TNNCIPQCA-SGC-PNGTCITPN----NCSCNK 147
            .|. ..||:   ....|:|:..:..|.|    .:.|:...: .|| ||..||..:    :|.|.:
Mouse   843 FCHIHATCEYSNETASCVCNDGYEGDGTLCSKKDPCLGSTSRGGCSPNAECIQASTGTYSCVCQR 907

  Fly   148 GYKLNPTTQV----C-LPT---CKDN--CAAVNGFCAAPNRCECNPGFIPKPKSKSFECQP---- 198
            |:..|....|    | ||:   |.||  |..|.   ...|.|||..||    :....:|:|
Mouse   908 GWTGNGRDCVEINSCLLPSSGGCHDNATCLYVG---PGQNECECKKGF----RGNGIDCEPIISC 965

  Fly   199 -----KCK--NGCS---NGVCRAPDKCECNKFYE------------------------------- 222
                 ||.  ..|.   :||.    .|.|.:.||
Mouse   966 LEQIEKCHPLATCQYTLSGVW----SCVCQEGYEGNGVLCYGNVLMELSFLSEAAVFYQWINNAS 1026

  Fly   223 ---------------------KDID---------GNCVPIC------------------------ 233
                                 ||:|         .|.:|..
Mouse  1027 LQSMLSATSNLTVLVPSLQAIKDMDQNEKSFWLSRNNIPALIKYHTLLGTYRVADLQTLPSSHML 1091

  Fly   234 ----------------------------ENGCVNG-------------NCTA------------P 245
                                        :|...||             ..|.            |
Mouse  1092 ATSLQGSFLRLDKADGNITIEGASFVDGDNAATNGVVHIINKVLIPQRGLTGSLPSLLTRLEQMP 1156

  Fly   246 DVCQCLTGYTKIGHNVCLAVCPEGCQNGVCVAPNECSCNAGYTKLEGVCTPVCKDGCVNGFCASP 310
            |. ....||. |.:|:..|:  |.........||..:..: |.: |...|.: |:..:.......
Mouse  1157 DY-SIFRGYI-IHYNLASAI--EAADAYTVFVPNNEAIES-YIR-EKKATSL-KEDILQYHVVLG 1214

  Fly   311 EKCSCND----------------------------------------------GYEMDSE---NR 326
            ||...||                                              |.|...|   ||
Mouse  1215 EKLLRNDLHNGMHRETMLGFSYLLAFFLHNDQLYVNEAPINYTNVATDKGVIHGLEKVLEIKKNR 1279

  Fly   327 CSPVCSGGCKNGFCVAPGKC-SCDEG--------------------YIKGTGN-------SC-KP 362
            |.       .|...:..||| .|.:.                    |..|..:       .| :.
Mouse  1280 CD-------NNDTIIVRGKCGKCSQQTLCPLETKPLSETRKCIYSVYFMGKRSIFIGCQLQCVRT 1337

  Fly   363 ICSKGCENGF----CDA-PEKCSCNDGYEMDGENRCSPVCSGGCKNGFCV----APGKCSCDEGY 418
            |.:..|..||    |.| |.|          |:|    ||||   ||||:    ..|.|.|::|:
Mouse  1338 IITSACCAGFFGPQCQACPGK----------GQN----VCSG---NGFCLDGVNGTGTCECEQGF 1385

  Fly   419 SKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEG 483
            :   |.:|: .|::|.....||  :.|||..|       ||:...||         .|.|.||.|
Mouse  1386 N---GTACE-TCTEGKYGIHCD--QACSCVHG-------RCNQGPSG---------DGSCDCDVG 1428

  Fly   484 YSKETGNSC-KPICSKGCENGFC----------DAPEKCSCNDGYEMDGENRCSPVCSGGCKNGF 537
            :   .|..| ..|.:..| ||.|          |....|.|..|::.:| ..|:.:.:....||.
Mouse  1429 W---RGVKCDSEITTDNC-NGTCHTSANCLLDPDGKASCKCAAGFQGNG-TVCTAINACEISNGG 1488

  Fly   538 CVAPEKCS----------CDEGYSKETGNSCKPICSNGC-EN-GFCD--------APEK--CSCN 580
            |.|...|.          |..||:.: |..|..|  |.| || |.||        .|.:  |:|.
Mouse  1489 CSAKADCKRTIPGSRVCVCKAGYTGD-GIVCLEI--NPCLENHGGCDRHAECTQTGPNQAVCNCL 1550

  Fly   581 DGYEMDGENRCSPVC---------SGGCKN-GFCVAPGK----CSCDEGYSKETGNSCKPICSKG 631
            ..|..||:     ||         :|||.. .||....:    |:|...|   ||:..  :|...
Mouse  1551 PKYTGDGK-----VCTLINVCLTNNGGCSPFAFCNHTEQDQRTCTCKPDY---TGDGI--VCRGS 1605

  Fly   632 CENGFCDAPEKCS---------------------------CNDGYEMDSE--------------- 654
            ..:   :.|:..|                           .:|.:..:|:
Mouse  1606 IHS---ELPKNPSTSQYFFQLQEHAVQELAGPGPFTVFVPSSDSFNSESKLKVWDKQGLMSQILR 1667

  Fly   655 ---------------------------------------NRCSPVCSGG--CKNG---------- 668
                                                   |:.:.|.|..  ..||
Mouse  1668 YHVVACQQLLLENLKVITSATTLQGEPISISVSQDTVLINKKAKVLSSDIISTNGVIHVIDTLLS 1732

  Fly   669 ---FCIAPGKCS-----------CDEGYSKET--------------------------------- 686
               ..|.|...|           .:.||:|.:
Mouse  1733 PQNLLITPKGASGRVLLNLTTVAANHGYTKFSKLIQDSGLLKVITDPMHTPVTLFWPTDKALQAL 1797

  Fly   687 ----------------------------------------------GNSCKPICSKGCENG---- 701
                                                          |:.....|..|.:.|
Mouse  1798 PQEQQDFLFNEDNKDKLKAYLKFHVIRDTMALASDLPRSASWKTLQGSELSVRCGTGSDVGELFL 1862

  Fly   702 ---FCDAPEKCSCNDG---YEMD-------SENRCSPVCS----GGCKNGFCVAPGKCSCDEGYS 749
               .|...::....||   |.:|       ...||....:    |.|  |.|.:..:|...   |
Mouse  1863 NGQMCRIIQRRLLFDGGVAYGIDCLLMDPTEGGRCDTFTTFNIPGEC--GSCFSTPRCPLQ---S 1922

  Fly   750 KETGNSCKPICS--------KGCENGFC----EAPEKCSCNDGYEMDGENRCSPVCSGG----CK 798
            |..|...|.|.:        :||:| .|    ..|..||   ||.|..   |. .|.||    |.
Mouse  1923 KPKGVRKKCIYNPLPFRRDVEGCQN-LCTLVVHVPRCCS---GYFMPD---CQ-ACPGGPDTPCN 1979

  Fly   799 N-GFCI----APGKCSCDEGYSRETGNSCK--------PICSK-GC-ENGFCD----APEKCSCN 844
            | |.|.    ..|:|.|..|::   |.:|:        |.|.. || |:|.||    ...:|.|.
Mouse  1980 NRGMCYDQYKPTGQCQCHTGFN---GTACELCLPGRFGPDCQPCGCSEHGQCDEGITGSGQCLCE 2041

  Fly   845 DGYE---MDSENRCSPVCSGGCK-NGFCVAPGKCSCDEGYSKETEISC--APFCKDGCVNGLCVS 903
            .|:.   .|:.....|||...|. :..|:....|.|:..|..: .|:|  ..|||..  ||.|..
Mouse  2042 AGWTGRFCDAPTVVIPVCIPACSMHATCMENNTCVCNLNYEGD-GITCTVVDFCKQN--NGGCAK 2103

  Fly   904 PDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDK--NCRNGTCVEGIC----TC-----SKQ--- 954
              ..||......|    ||...|...||...|.:  .|.||  |.|.|    ||     .||
Mouse  2104 --VAKCSQKGTQV----SCSCQKGYKGDGHSCTEIDPCANG--VNGGCHEHATCRMTGPGKQKCE 2160

  Fly   955 YKLHRNEDDNNLICLPICEPE------CL--NGLCEFPGSCV----------CWDGESPIDGY-- 999
            .|.|...|..:      ||||      ||  ||.|....:||          .:...||:..|
Mouse  2161 CKSHYVGDGRD------CEPEQLPLDRCLQDNGQCHPDANCVDLHFQDTTVGVFHLRSPLGQYKL 2219

  Fly  1000 -------SC----QSMDSLGSLTGHEKSERHL 1020
                   :|    .|:.:...|:..:|::.||
Mouse  2220 TFDKAKEACAKEAASIATYNQLSYAQKAKYHL 2251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Stab2	NP_619614.1	EGF_3	254..283	CDD:289699
		EGF_3	334..369	CDD:289699
		Fasciclin	390..512	CDD:280607
		Fasciclin	533..661	CDD:280607
		EGF_3	844..872	CDD:289699	7/27 (26%)
		EGF_3	928..959	CDD:289699	11/37 (30%)
		EGF_3	965..1001	CDD:289699	9/39 (23%)
		Fasciclin	1018..1137	CDD:280607	8/118 (7%)
		Fasciclin	1156..1273	CDD:280607	20/123 (16%)
		EGF_3	1482..1518	CDD:289699	9/36 (25%)
		EGF_3	1524..1560	CDD:289699	12/40 (30%)
		EGF_3	1566..1602	CDD:289699	10/40 (25%)
		Fasciclin	1628..1733	CDD:280607	7/104 (7%)
		Fasciclin	1758..1889	CDD:280607	12/130 (9%)
		EGF_3	2094..2129	CDD:289699	13/42 (31%)
		EGF_3	2135..2172	CDD:289699	13/44 (30%)
		Link_Domain	2206..2297	CDD:295393	9/46 (20%)
		FAS1	2363..2452	CDD:214719
		Interaction with TMSB4X. /evidence=ECO:0000250	2510..2520
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2514..2559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900