DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and F48E3.8

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001360756.1	Gene:	F48E3.8 / 181010	WormBaseID:	WBGene00018607	Length:	2111	Species:	Caenorhabditis elegans

Alignment Length:	1635	Identity:	349/1635 - (21%)
Similarity:	470/1635 - (28%)	Gaps:	744/1635 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLVSAQICTVNVTRNIKGTAVNVQTRDCCKGYKKVRSSALRCLAQCKV----NCGSG-------F 67
            |....::|.        |.:|.|..:..|.. .||..:.: |:.|...    .||.|       :
Worm   532 GCTMGEMCV--------GNSVCVNGKCACVD-GKVEINKI-CIDQVSAKPGDTCGKGIICEGGSY 586

  Fly    68 C-TKPNVCTCKKGYVNLNN--------DPSNRCVPYCKGCSRGTCQSPGRCICSAR-HLLDKTTN 122
            | |....|.|::|..::|.        .|.:.|......|:.|:..:.|||.|..| ..:||
Worm   587 CNTDSGKCACRRGENSINGICKGFTFVYPGDLCTDITSRCTGGSYCARGRCECPPRMSAIDK--- 648

  Fly   123 NCIPQ--------------CA--SGCPNGTCITPNN-------C----SCNKGYKLNPTTQVCL- 159
            .|:.|              |:  |.|.|..|...||       |    ..|.|...|...| ||
Worm   649 KCVHQQTAAPGEPCSEKVACSPFSVCENNVCKCVNNMMIRDKMCVQRRKVNIGNSCNNEDQ-CLG 712

  Fly   160 -PTCKDNCAAVNGFCAAPNRCECNPGFIP--------KPKSKSFECQPK--C--KNGCSNGVCRA 211
             .||.|            |.|:|..||:.        |..:..:.|.|:  |  ::.|..||
Worm   713 NSTCMD------------NNCQCGIGFVASMDVCVLRKTVTPGYLCNPEDICTGQSVCIKGV--- 762

  Fly   212 PDKCECNKFYEKDIDGNCV---------PI-----CENGCV---NGNCTAPDVCQCLTG----YT 255
               |:|...| |.:...||         |.     |..|.:   :|.|:.|:....:.|    |.
Worm   763 ---CQCQPDY-KQMHNICVKKNIGIEGSPCSSRDDCGEGLMCGASGKCSCPEGLFSVNGKCRSYV 823

  Fly   256 KIGHNVCLA--VCPEGCQNGVCVAPNECSCNAGYTKLEGVC-----TPV-------CKDGCVNGF 306
            ::| ..|.:  .|.|  :|..| ..|.|:|..|||.:.|.|     ||.       .|.|.:...
Worm   824 QLG-QTCTSDDRCAE--RNAQC-QENYCTCRTGYTNINGQCAANIVTPAEPETLSQVKSGLLGHI 884

  Fly   307 CASPEK------------CSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGK----CSCDEGYIKG 355
            |.|.:.            |.|.|||.:....:|.|            .|||    .:..|..:..
Worm   885 CTSNDHCKIAHSQCRRNVCQCIDGYRIFGSTQCIP------------RPGKPKERKTEKESKLVE 937

  Fly   356 TGNSCK--PICSKG--CENGFCDAPE-------KC---------------SCNDGYEMDGENRC- 393
            .|:.|.  .:||||  ||.|.|..||       .|               ||..|.|..|.:.|
Worm   938 LGDKCDKLSLCSKGAICEKGVCSCPETFFESDGACVKNVAKIKVVVPPLSSCLGGEECSGNSECV 1002

  Fly   394 SPVCSGGCKNGFCVAPGKC---------------------------------------------- 412
            ..:|.  ||..|.:..|||
Worm  1003 HGICF--CKEEFTLFEGKCQRLRIIEKLTVLESKKLIKPIKAHTTPTAASNTTPIPVKTTTTLQT 1065

  Fly   413 ----SCDEGY-SKETGNSCKPI-----------------------------------------CS 431
                :..|.| |..|.....||                                         ||
Worm  1066 TTATTLPENYVSSSTNRPLTPIIISMKLGSTSSPSPQITSNPEYKWRLSKPGHMCDNKTHCTNCS 1130

  Fly   432 KGCENGFCDAPE-------KCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETG 489
            . |.||||..||       ||..    |:|: .:|  :.|..|.:|.....|:|.|..|......
Worm  1131 V-CVNGFCRCPEGLVHYGDKCVS----EIDA-TKC--LASNQCPSGAQCVKGECRCKPGLGITRY 1187

  Fly   490 NSCKPI--------CSKG--------CENGFCDAPEKCSCNDGYEMDGENRC--SP--------- 527
            ..|.||        |:.|        ||:|.      |:||:...:. ||:|  ||
Worm  1188 GFCVPITFAEPGTSCAYGEHCQKDSHCEDGL------CTCNEPLVLK-ENKCVVSPREKRFISDV 1245

  Fly   528 ----------------------------------VC--------------------------SGG 532
                                              ||                          ...
Worm  1246 HRKLLRFTPKKLAKLGEYCFRNSHCESQRQCLKNVCKCASNFVQSSFSCVPRMSVISSLALPGES 1310

  Fly   533 CKNGFCVAPE-----KCSCDEGYSKETGNSC-------KPIC--SNGCENGFCDAPEKCSCNDGY 583
            |:.||||...     .|.|.:.|.|: |:||       ...|  ::||..|.......|.|.|.|
Worm  1311 CRKGFCVGGSTCENFMCKCPDDYFKK-GDSCVRYESRIGAACGTASGCSGGATCTSSFCQCQDQY 1374

  Fly   584 EMD--------------------GENRCSPVCSG---GCK------NGFCV-----------APG 608
            :.|                    |..:.:.|.|.   .|.      ||.||           |||
Worm  1375 DADVDECYPYEPSVRSRNVKAISGRRKVNRVVSASTINCPIGYDLVNGMCVNSETLSVIQLAAPG 1439

  Fly   609 KCSCDEGYSKETGNS------CKPICSKG--CENGFC---------------------------D 638
            . :|::|....||||      |  ||..|  .:||.|                           |
Worm  1440 G-ACEDGTILCTGNSVCANNVC--ICPGGETVQNGTCVSINTYSSPGDPCDLTNTICTGNSQCID 1501

  Fly   639 APEKCSCNDGYEMDSENRCSPVCSGGC------KNGFCIAPGKCSCDEGYSKETGNSCKPIC--- 694
            ...||..|.|   ....|||.:.:..|      .|..|| ...|.|..||.::.|:..:..|
Worm  1502 GICKCPNNQG---AINGRCSNMGNANCGNIQCGTNQICI-QDSCQCRPGYYQQPGSCLQDRCNCI 1562

  Fly   695 ----SKGCENGFCD-----APEKCSCNDGY----EMDSENRCSPV------CSGGC-----KNGF 735
                |..|.|..|.     ..::|.|..||    |....:||:.|      .||||     .|..
Worm  1563 QEVESDSCLNRQCGMNQVCIQDQCQCRSGYLVLQETCISDRCNCVQPSVDAISGGCMNQCGNNQV 1627

  Fly   736 CVAPGKCSCDEGYSKE----TGNSCKPI---------CSKGCENGFCEAPEKCSCNDGYEMDGE- 786
            |: ..:|.|..||..:    ||:.|..:         |.:.|.|......::|.|.:||....|
Worm  1628 CI-QDQCLCRNGYYAQPETCTGDRCNCVQHVVPDMGNCQRQCGNNQVCIQDQCQCRNGYYAQTET 1691

  Fly   787 ---------------------NRCSP----------------VC-----------SGGCKNGFCI 803
                                 |.|:|                :|           ...|.|.:||
Worm  1692 CVADKCNCVQRAVAIPSPCVGNGCAPSAQSQSYLQFIGLPGKMCDLRPNAIPCRNDAQCVNNYCI 1756

  Fly   804 APGK--------------------------------------CSCDEGYSRET------------ 818
            .|..                                      |.|..|:|.:.
Worm  1757 CPSNRVISGSNCVFYLGDALPGQSCQNNGMICRGGSSCNQNICQCAVGFSVDNGRCTPTIEVRFT 1821

  Fly   819 -----------------GNSCKPICS-----------KGCENGFCDAPE-------KCS----CN 844
                             |.:|.|.|:           ..|.|..|..|:       .||    .|
Worm  1822 MLPVTTAIPVFIIELNPGQTCDPSCAYQPCMQRCSGGSSCSNSICSCPQGSGVLNNVCSPSFPQN 1886

  Fly   845 DGYEMDSENR----C--SPVCSGGCKNGFCVAPGKCSCDEGYSKETEISCAPFCKDGCVNGLCVS 903
            |.|.:....|    |  :.||.||..   |:. |.|.||.||...::.|.            ||.
Worm  1887 DNYNLTRTARPGDSCDNTIVCIGGSS---CLI-GTCLCDSGYEPSSDRSS------------CVL 1935

  Fly   904 PD------------FC----KCDDGYIFVEESKSCQLDKELLGDY-------------SDCDK-- 937
            .|            ||    :|..|.|.:::..:|:.|.|::...             |.|.|
Worm  1936 NDRYNVRSRSYPKTFCTFDSECTGGSICIDKRCACRNDHEMINGVCQLANLPGSRCHTSFCSKGA 2000

  Fly   938 NCRNGTCVEGICTCSKQYKLHRNEDDNNLICLPICEPECLNGLCEFPGS-C----VCWDGESPID 997
            .||||.||     |:|     .|..|:.|.|  :.......|...:||| |    .|....|...
Worm  2001 ECRNGYCV-----CAK-----TNYSDSTLDC--VSSINANQGSMAYPGSKCNATTSCQQNSSCFF 2053

  Fly   998 GYSCQSMDSL 1007
            ||.....|.:
Worm  2054 GYCVTPQDEI 2063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
F48E3.8	NP_001360756.1	EB	98..154	CDD:366756
		EB	224..280	CDD:366756
		EB	300..351	CDD:366756
		EB	340..392	CDD:366756
		EB	<438..476	CDD:366756
		EB	514..563	CDD:366756	8/40 (20%)
		EB	552..607	CDD:366756	14/56 (25%)
		EB	596..650	CDD:366756	14/56 (25%)
		EB	639..692	CDD:366756	13/55 (24%)
		EB	681..734	CDD:366756	17/65 (26%)
		EB	723..776	CDD:366756	14/59 (24%)
		EB	808..860	CDD:366756	16/55 (29%)
		EB	961..1019	CDD:366756	14/59 (24%)
		EB	<1111..1150	CDD:366756	9/39 (23%)
		EB	1283..1340	CDD:366756	10/57 (18%)
		EB	1413..1473	CDD:366756	20/62 (32%)
		EB	1462..1517	CDD:366756	10/57 (18%)
		EB	1757..1812	CDD:366756	5/54 (9%)
		EB	<1893..1930	CDD:366756	13/40 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000