DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and Y64G10A.7

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001255802.1	Gene:	Y64G10A.7 / 178377	WormBaseID:	WBGene00013416	Length:	1714	Species:	Caenorhabditis elegans

Alignment Length:	1492	Identity:	381/1492 - (25%)
Similarity:	484/1492 - (32%)	Gaps:	601/1492 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CTVNVTRNIKGTAV------NVQTRDCCKGY--KKVRSSALRCLAQ---CKVNCGSGFCTKPNVC 74
            |:.::..| .||.|      |.|..:|..|:  .|.:..|..|:|.   |:..|.:...|  ..|
Worm   118 CSADLCHN-GGTCVPSEHNDNEQVCECPVGFTGAKCQYDANECMANNGGCEHECVNTIGT--YYC 179

  Fly    75 TCKKGYVNLNNDPSNRC--VPYCK----GCSRGTCQSPG--RCICSARHLLDKTTNNC--IPQCA 129
            .|..|: .|:.| .|.|  :..|.    |||.....|||  ||.|.:...|......|  :..|:
Worm   180 RCWPGF-ELSGD-GNTCSDIDECAVSNGGCSDRCVNSPGGFRCDCPSDLYLHADGRTCGKVTSCS 242

  Fly   130 S---GCPNGTCITPNN-----CSCNKGYKLNPTTQVCLPT--CKDNCAAVNGFCAAPN---RCEC 181
            :   ||.: .|...:|     |.|..|:||:...:.|.|.  |.||.......|...:   :|:|
Worm   243 TDNGGCEH-ECENDSNGEFYRCRCRVGFKLSENKRSCQPVDPCFDNKGGCQHHCTNNHGRAQCQC 306

  Fly   182 NPGFIPKPKSKSF----ECQPK--CKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICE---NGC 237
            .|||......:|.    ||...  |::.|.|  .:...:|:|.:.|:...||.   .||   .||
Worm   307 YPGFHLSYDRRSCVDIDECAKNNGCEHFCEN--VKGTYRCKCREGYQLGRDGR---TCEEMLGGC 366

  Fly   238 V--NGNC-----TAPD---VCQCLTGY-----TKIGHN----VCLAVCP---EGCQNGVCVAPN- 279
            .  ||.|     ..||   ||:|..||     .|:.|:    |..|..|   :..:...||.|.
Worm   367 QVGNGGCQHDCYDQPDGGHVCKCRNGYILANDQKLCHDNISTVIHARAPRLWDSYETVTCVTPTD 431

  Fly   280 ---------------ECSCNAGYTKLEG-VCTPV---------CKDGCVNGFCASPEKCSCNDGY 319
                           :|.|:.||..::. .|..:         |...|||  .|...:|.|..|:
Worm   432 LTCHKLCMHLDSGHVQCFCDDGYELIDSKFCQDINECHENNGDCSQICVN--LAGSVECQCKPGF 494

  Fly   320 E-MDSENRCSPV--CS---GGC-------KNGFCVAPGKCSCDEGY-IKGTGNSCKPI------- 363
            . |.....|..:  ||   |||       :.|:     .|||:.|: :...|:||..:
Worm   495 RLMKDRKTCEDISECSSNNGGCEQICSNQEGGY-----MCSCEPGFELSEDGHSCHDMNECLINN 554

  Fly   364 --CSKGCEN-----------GFCDAPEKCSC-----------ND--------------------- 383
              |::.|:|           |:..|.::.||           ||
Worm   555 GGCAQLCKNRKGSRRCQCFAGYILAHDEKSCVAASDSADIFSNDIEDYSKVPGLDSIDEVISSIE 619

  Fly   384 GYEMDGENRCSPVCSG------GCKNGF-----------CVAPGKCS-----------CDEGYSK 420
            .|..|...|  |:..|      .|.|||           |...||||           |..||
Worm   620 SYPADESPR--PLVFGRRRHVKECPNGFFGSTCQLSCSDCQNGGKCSMRGSGLLSKCDCPSGY-- 680

  Fly   421 ETGNSCKPICSKG---------CENGFCDA---------PEKCS---CNDGY---------EMDS 455
             ||..|:.||..|         |....||.         |||||   |.||:         .||.
Worm   681 -TGEKCEQICRNGYWGVDCAHKCSCKLCDPSTGSCRCEDPEKCSDGPCPDGFYGSQCNLKCRMDC 744

  Fly   456 EN-RCSPV-----CSGGCKNGFCVAP----------------------------GKCSCDEGYSK 486
            .| ||.||     |..|.....|..|                            |||.|..||
Worm   745 PNGRCDPVFGYCTCPDGLYGQSCEKPCPHFTFGKNCRFPCKCARENSEGCDEITGKCRCKPGY-- 807

  Fly   487 ETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDGENRCSPV-------CSGGCKNGFCVAP--- 541
             .|:.||.:||.|.....|  ..||||..|.      ||.||       |..|.:...|..|
Worm   808 -YGHHCKRMCSPGLFGAGC--AMKCSCPAGI------RCDPVTGDCTKKCPAGYQGNLCDQPCPA 863

  Fly   542 --------EKCSCDEGYSKETGNSCK--------------PICSNGCENGFCDAP--------EK 576
                    :||||.:..|......|.              |:|...|      ||        ..
Worm   864 GYFGYDCEQKCSCADVASPHKSKVCHHVTGTCTCLPGKTGPLCDQSC------APNTYGPNCAHT 922

  Fly   577 CSCNDGY---EMDGENRCSP---------VCSGG-----------CKNG-FC-VAPGKCSCDEGY 616
            |||.:|.   |.||...|:|         ||..|           |:|| .| .:.|.|.|..|:
Worm   923 CSCVNGAKCDESDGSCHCTPGFYGATCSEVCPTGRFGIDCMQLCKCQNGAICDTSNGSCECAPGW 987

  Fly   617 SKETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMD-SENRCSPVCSGGCKNGFCIAPGKC--SC 678
            |   |..|...|:.|.....|.  :||.|.||...| |:..|  :|..| |.|.     ||  :|
Worm   988 S---GKKCDKACAPGTFGKDCS--KKCDCADGMHCDPSDGEC--ICPPG-KKGH-----KCDETC 1039

  Fly   679 DEGYSKETGNSCKPICSKGCENG-FCDA-PEKCSCNDGYEMDSENRCSPVC-----SGGCKNGFC 736
            |.|.   .|..||.|||  |:|| .||: ...|.|..|:.   ..:|...|     ..|| |..|
Worm  1040 DSGL---FGAGCKGICS--CQNGATCDSVTGSCECRPGWR---GKKCDRPCPDGRFGEGC-NAIC 1095

  Fly   737 --------------VA-----PGKCSCDEGYSKETGNSCKPICSKG-----------CEN----- 766
                          ||     .|:|.|..|:   ||..|:..|..|           |.|
Worm  1096 DCTTTNDTSMYNPFVARCDHVTGECRCPAGW---TGPDCQTSCPLGRHGEGCRHSCQCSNGASCD 1157

  Fly   767 ---GFCEAP----------------------EKCSCNDGYEMDGEN------------RCSPVCS 794
               |||:.|                      :.|.|..|.|.:.||            .|..:|.
Worm  1158 RVTGFCDCPSGFMGKNCESECPEGLWGSNCMKHCLCMHGGECNKENGDCECIDGWTGPSCEFLCP 1222

  Fly   795 GG-----------CKNGFCI--APGKCSCDEGYSRETGNSCKPICSKG-----------CENG-F 834
            .|           ||||...  ..|:|.|..|:|   |..|:..|..|           |||| .
Worm  1223 FGQFGRNCAQRCNCKNGASCDRKTGRCECLPGWS---GEHCEKSCVSGHYGAKCEETCECENGAL 1284

  Fly   835 CD-APEKCSCNDGYEMDSENR----------CSPVC-----------SGGC-------------- 863
            || ....|||..|:.....||          ||..|           ||.|
Worm  1285 CDPISGHCSCQPGWRGKKCNRPCLKGYFGRHCSQSCRCANSKSCDHISGRCQCPKGYAGHSCTEL 1349

  Fly   864 -----------------KNGFCVA-PGKCSCDEGYSKETEISCAPFCKDGCVNG--------LC- 901
                             :|..|.| .|||.|..|:|...       ||.|||.|        ||
Worm  1350 CPDGTFGESCSQKCDCGENSMCDAISGKCFCKPGHSGSD-------CKSGCVQGRFGPDCNQLCS 1407

  Fly   902 --------VSPDFCKCDDGYIFVEESKSCQLDKELLGDYSDCDK--NCRN-GTC--VEGICTCSK 953
                    .|...|.|..|||..:...:||.|:  .|  ..|:|  ||.| |||  :.|.|.|..
Worm  1408 CENGGVCDSSTGSCVCPPGYIGTKCEIACQSDR--FG--PTCEKICNCENGGTCDRLTGQCRCLP 1468

  Fly   954 QYKLHRNEDDNNLICLPICEPE------------CLNGLCE-FPGSCVCWDGESPIDGYSCQ 1002
            .:        ..:.|..:| ||            |.||.|. ..|.|.|..|   ..|.||:
Worm  1469 GF--------TGMTCNQVC-PEGRFGAGCKEKCRCANGHCNASSGECKCNLG---FTGPSCE 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Y64G10A.7	NP_001255802.1	EMI	35..105	CDD:284877
		FXa_inhibition	159..194	CDD:291342	11/38 (29%)
		FXa_inhibition	200..235	CDD:291342	11/34 (32%)
		FXa_inhibition	241..278	CDD:291342	10/37 (27%)
		vWFA	<319..358	CDD:294047	10/43 (23%)
		FXa_inhibition	366..402	CDD:291342	12/35 (34%)
		vWFA	<460..502	CDD:294047	10/43 (23%)
		FXa_inhibition	509..544	CDD:291342	11/39 (28%)
		FXa_inhibition	550..585	CDD:291342	5/34 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910