Protein Alignment eater and megf11

DIOPT Version :10

• Sequence 1: NP_651533.3
• Gene: eater / 43262
• FlyBaseID: FBgn0243514
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_002938407.3
• Gene: megf11 / 100490321
• XenbaseID: XB-GENE-6045392
• Length: 1053
• Species: Xenopus tropicalis
• Alignment Length: 1210
• Identity: 302/1210 - (24%)
• Similarity: 409/1210 - (33%)
• Gaps: 467/1210 - (38%)

  Fly     2 WICRITIYSLLLG---LVSAQICTVNVTRNIKGTAVNVQ------------TR--------DCCK 43
            |..:|.:..|:||   |::.:  ..||..:.:..||.||            ||        .|.:
 Frog     9 WTVKILVLYLVLGTAVLLNPE--DPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTR 71

  Fly    44 ---GYKKVRSSALRCLAQCKVNCGSGFCTKPNVCTCKKGYVNLNNDPSNRCVPYC-KGCSRGTCQ 104
               .||......||.:.:.:..|..|:                 .:..:.|:|.| :.|..|.|.
 Frog    72 HRISYKTAYRRGLRTMYRRRSQCCPGY-----------------YESGDFCIPLCTEECVHGRCV 119

  Fly   105 SPGRCICSARHLLDKTTNNCIP-----QCASGC------PNGTCITPNNCSCNKGYKLNPTTQVC 158
            ||..|             :|.|     .|:|||      |:  |  .|.|.|......||.|..|
 Frog   120 SPDTC-------------HCEPGWGGADCSSGCDSEHWGPH--C--SNRCQCQNEALCNPITGAC 167

  Fly   159 LPTCKDNCAAVNGFCAAPNRCE--CNPGFIPKPKSKSFECQPKCKNGCSNGVCRAPDKCECNKFY 221
            :  |.|   ...|:     |||  |:||...|      .||.:|:
 Frog   168 V--CSD---GYRGW-----RCEDWCDPGTYGK------ACQLRCQ-------------------- 196

  Fly   222 EKDIDGNCVPICENGCVNGNCTAPDVCQCLTGYTKIGHNVCLAVCPEG-----------CQN-GV 274
                       |:||....:.|..  |.|..|||..   .|..:||.|           ||| ||
 Frog   197 -----------CQNGATCDHRTGE--CHCAPGYTGA---FCEELCPPGSHGALCELRCPCQNGGV 245

  Fly   275 C-VAPNECSCNAGYTKLEGVCTPVCKDGCVNGFCASPEKCSCNDGYEMDSENRCSPVCSGGCKNG 338
            | ....:|||.||:|..  ||...|..|.....|:  ::|.|::|      .:|.|:
 Frog   246 CHHVTGDCSCPAGWTGT--VCAQPCPSGRFGVNCS--QECQCHNG------GQCDPL-------- 292

  Fly   339 FCVAPGKCSCDEGYIKGTGNSCKPICSKGCENGFCDAPEKCSCNDG---YEMDGENRCSP----- 395
                .|:|.|..||   ||..|:..|..|.....|  .|:|.|.:|   |.::|...|.|
 Frog   293 ----SGRCQCAAGY---TGERCQEECPVGTYGFQC--AERCDCQNGAKCYHINGACLCEPGFKGI 348

  Fly   396 -----VCSGG-----C-KNGFC---------VAPGKCSCDEGYSKETGNSCKPICSKGCENGFCD 440
                 ||..|     | ||..|         ...|:|:|..|:|   |..|:..|..|.....|.
 Frog   349 LCEERVCPEGLYGLKCNKNCPCNLTNTRGCHPLSGECTCRAGWS---GLYCEEPCRPGFYGEGCQ 410

  Fly   441 APEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCENGFC 505
              :.|||::|.:.||                  ..|:|.|..||   ||..|...|:.|...  .
 Frog   411 --QLCSCHNGADCDS------------------MTGRCICAPGY---TGQDCSAPCATGTFG--A 450

  Fly   506 DAPEKCSC-NDGYEMDGENRCSPVCSGGCKNGFCVAPEKCSCDEGYSKETGNSCKPICSNGCENG 569
            |....|:| ||.       .||||      :|.||      |.||:.   |..|...||:|....
 Frog   451 DCLSVCNCQNDA-------ACSPV------DGLCV------CREGWQ---GLDCSIPCSSGTWGL 493

  Fly   570 FCDAPEKCSC-NDGYEMDGENRCSPVCSGGCKNGFCVAPGKCSCDEGYSKETGNSCKPICSKGCE 633
            .|:  :.|.| ||.       .|||:            .|.|:|..|:..|       :|.:.|.
 Frog   494 NCN--QSCLCLNDA-------SCSPM------------DGSCTCAPGWIGE-------LCDQPCL 530

  Fly   634 NGF--CDAPEKCSCN--DGYEMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKETGNSCKPIC 694
            :|.  .|..|.|.|:  ||        |:||            .|.|.|..|:   ||..|..:|
 Frog   531 DGAYGMDCLEHCDCSHADG--------CNPV------------SGHCHCLAGW---TGIHCDNLC 572

  Fly   695 SKG-----------CENGFCDAPE--KCSCNDGYEMDSENR----------CSPVC------SGG 730
            ::|           ||||...:||  .|.|..||......|          ||..|      ||.
 Frog   573 NQGYWGPNCSMTCHCENGGSCSPEDGSCECAPGYRGALCQRICAAGFYGHQCSQTCPQCVHFSGP 637

  Fly   731 CKNGFCVAPGKCSCDEGYSKETGNSCKPIC-----SKGCENGFCEAPEKCSCNDGYEMDGENRCS 790
            |.:    ..|.|.|..|:   .|..|..:|     .|||       .|.|||::      ...|:
 Frog   638 CHH----VTGHCDCLPGF---FGPLCNQVCPSGRFGKGC-------AEICSCSN------NATCN 682

  Fly   791 PVCSGGCKNGFCIAPGKCSCDEGYSRETGNSCK---------PICSKGCENGFCDAPEKCSCNDG 846
            ||            .|.|.|..|:   .|..|.         |.||..|.   |....:||..||
 Frog   683 PV------------DGSCQCYPGW---IGIDCSDECPFGLWGPDCSHTCN---CHNEAECSAYDG 729

  Fly   847 YEMDSENRCSP-----VCSGGCKNGFCVAPGKCSCDEGYSKETEISCAPFCKDGCVNGLCVSPDF 906
                 |.:|:|     .|:..|.:.|            |.|:    ||..|:  |.||
 Frog   730 -----ECKCTPGWTGLYCTQRCPSAF------------YGKD----CANVCQ--CHNG------- 764

  Fly   907 CKCDDGYIFVEESKSCQLDKELLGDYSDCDKNCRNGTCVEGICTCSKQYKLHRNEDDNNLICLPI 971
            ..||      ..:..|.......|::  |::.|..||...|                    |..:
 Frog   765 ADCD------HITGQCTCRTGFTGNH--CEQKCPPGTFGYG--------------------CRQL 801

  Fly   972 CEPECL-NGLCE-FPGSCVCWDGESPIDGYSCQS----MDSLGSLT----GHEKSERHLKWVFIT 1026
            |  ||| |..|: ..|:|.|..|   ..|..|..    |:.|...|    .| .||||.....|.
 Frog   802 C--ECLNNATCDHVTGTCYCNPG---FKGIRCDQAALMMEELNPYTKISPAH-GSERHSAGAIIG 860

  Fly  1027 IVSMAFILAIITTMLIIYIFRKRSYHVDKNEREFGVYFSP 1066
            ::  ..:|.|:|.:.:..::|:|  ..||:.....|.::|
 Frog   861 VI--VLLLIIMTLLGLFLVYRQR--QKDKDHDMPNVAYTP 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
megf11	XP_002938407.3	EMI	31..100	CDD:462204	15/85 (18%)
		EGF_CA	281..326	CDD:473889	18/67 (27%)
		EGF_CA	759..804	CDD:473889	15/83 (18%)