DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eater and Stab1

DIOPT Version :9

Sequence 1:	NP_651533.3	Gene:	eater / 43262	FlyBaseID:	FBgn0243514	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_008769275.1	Gene:	Stab1 / 100363145	RGDID:	2324745	Length:	2630	Species:	Rattus norvegicus

Alignment Length:	1302	Identity:	277/1302 - (21%)
Similarity:	383/1302 - (29%)	Gaps:	614/1302 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 ITPNNCSCNKGYKLNPTTQVCLPTCKDNCAAVNGFCAAPNRCECNPGFIPKPKSKSFEC----QP 198
            |.|.:|.       ....|..|.:|.| |.|:|.....||..:.:  ..||      ||    .|
  Rat   653 ILPKHCD-------EEQHQTVLGSCVD-CQALNTSICPPNSVKMD--IFPK------ECVYTHDP 701

  Fly   199 K----CKNGCSNGVCRAPDKCECNKFYEKDIDGNCVPICENGCVNGNCTAPDVCQCLTGYTKIGH 259
            .    .|.||:.         .||:           .|.:.||..| ...||..||..|::
  Rat   702 AGLNVLKKGCAE---------YCNQ-----------TITKRGCCKG-FFGPDCTQCPGGFS---- 741

  Fly   260 NVCLAV--CPEGCQ-NGVCVAPNECSCNAGYTKLEGVCTPVCKD------------GCVNGFCAS 309
            |.|...  |.:|.| ||.|:      |...|   :|:...:|.:            |||:|.|
  Rat   742 NPCYGKGNCSDGVQGNGACL------CFPDY---KGIACHICSNPNKHGEQCQEDCGCVHGLC-- 795

  Fly   310 PEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS--CDE-----GYIKGTGNSCKPICSKG 367
                          :||  |...|.|:.|.| |||...  |:|     |.: |....|.|
  Rat   796 --------------DNR--PGSGGVCQQGTC-APGFQGRFCNESMGNCGSL-GLAQPCHP----- 837

  Fly   368 CENGFCDAPE---KCSCNDGYEMDGEN--RCSPVCS----GGC-KNGFCVAPG-----KCSCDEG 417
              :..|...|   :|.|:||:|.:|.:  |.|| ||    ||| :|..|| ||     :|.|.:|
  Rat   838 --DAHCVIQEGVARCVCHDGFEGNGFSCKRSSP-CSHPDRGGCSENAECV-PGDLGTHQCICHKG 898

  Fly   418 YSKETGNSCKPICSKGCE-NGFCDA----------PEKCSC-----NDGYEMDSENRCSPV--C- 463
            :|.: |..|..|...|.: .|.|.|          ..:|:|     .||||      |||:  |
  Rat   899 WSGD-GRICVAIDECGLDTRGGCHADALCSYVGPGQSRCTCKLGFAGDGYE------CSPIDPCR 956

  Fly   464 --SGGCKN-GFCVAPG----KCSC-----DEGYS-------KETGNSCKPICSKGCENGFCDAPE 509
              :|||.. ..|.|.|    .|:|     .:|:|       :...|:.....|:..:|.....|.
  Rat   957 VGNGGCHGLATCKAVGGGQRVCTCPPHFGGDGFSCYGDIIQELEANAHFSAFSQWFKNSSITLPA 1021

  Fly   510 --KCSC-----------------------------------------NDGYEMD----------- 520
              |.:.                                         :.|:::|
  Rat  1022 DGKLTALVPSESAIRRLRPEDQAFWLQPKTLPELVRWGELGRKGHGGDSGWDLDPSQTMLREFPW 1086

  Fly   521 ----GENRCSPVC-------------------------------------------------SGG 532
                ||.|...:|                                                 ||.
  Rat  1087 LTKVGEPRLKELCNLVQSPPPPTLLLRAHFLQGAFSEEELARLSGQQVATLSATTHWQIHNTSGR 1151

  Fly   533 CK--------------NGF------CVAPEKCSCDEG---------------------------- 549
            .:              ||.      .:.|.:.....|
  Rat  1152 VQVQNATVDVPDLLATNGVLHIISQVLLPPRGDMQTGPGLLQQLDSVPAFRLFGEQLKHHKLVAQ 1216

  Fly   550 --------------YSKET-GN------------------------------------------- 556
                          :|.|| ||
  Rat  1217 IEAAKAYTIFVPTNHSLETQGNKSILGIDIVRHHVILGEALSVEVLRKGGHRNSLLGPAHWLVFY 1281

  Fly   557 --SCKP---------------------------ICSNGCENGFCDA-PEKC-------SCNDGYE 584
              |.:|                           :.|:.|.:...:| .|||       .|..|::
  Rat  1282 NHSGQPEVNHVPLEGPLLEAPGSALFGLSGILAVGSSRCLHSHAEALREKCVNCTRKFRCTQGFQ 1346

  Fly   585 MDGENRCSPV----------CSGGCKNGFCVAPGKCSCDEGYSKETGNSCKP-------ICS--K 630
            :....|.|.|          ||..|.....|.    .|..|:   .|..|:|       :||  .
  Rat  1347 LQDTPRKSCVYRSGLSFSRGCSYTCAKKIQVP----DCCPGF---FGTLCEPCPGGLGGVCSGHG 1404

  Fly   631 GCENGFCDAPEKCSCNDGY-----EMDSENRCSPVCSGGCKNGFCIAPGKCSCDEGYSKE--TGN 688
            .|::.|....| |.|.:|:     ||....|..|.||           |.|.||.|..:|  .||
  Rat  1405 QCQDRFLGNGE-CRCQEGFHGTACEMCELGRYGPTCS-----------GVCDCDHGLCQEGLRGN 1457

  Fly   689 -SCKPICSKGCENGFCD-------APEKCSCNDGYEMDSENRCSPVCSGGCKNGFCVAPGKCS-- 743
             ||  ||:.|.:...||       .|:||..|.....||..  .|||.  |..|:......||
  Rat  1458 GSC--ICNVGWQGLRCDQKITDRQCPKKCDPNANCIQDSAG--IPVCV--CAAGYSGNGSYCSEV 1516

  Fly   744 --CDEGYSKETGNSCKPI--CSKGCENGFCEAP--EKCSCNDGYEMDGE-----NRCSPVCSGGC 797
              |..|:     ..|.|.  |:|       .||  ..|:|.|||..|||     |.|. |.:|||
  Rat  1517 DPCTSGH-----GGCSPYANCTK-------VAPGQRTCTCLDGYTGDGELCQEINSCL-VHNGGC 1568

  Fly   798 K-NGFCIAPG----KCSCDEGYSRETGNSCKPICSKGCENGFCDAPEKCSCNDGYEMDSENRCSP 857
            . |..||..|    .|:|.||||.:...|||.:             :.||.|:|       .|||
  Rat  1569 HVNAECIPTGPQQVSCNCREGYSGDGIQSCKLL-------------DPCSQNNG-------GCSP 1613

  Fly   858 VCSGGCKNGFCVAPGK--CSCDEGYSKETEISCAPFCKDGCVNGLCVSPDFCKCDDGYIFVEESK 920
            ...  ||:   ...|:  ||||..::....|:|                      .|.:.:|..:
  Rat  1614 YAV--CKS---TGDGQRTCSCDSTHTVGDGITC----------------------HGRVGLELLR 1651

  Fly   921 SCQLD---------KELLGD--------YSDCDKNCRNGTCV----------------------- 945
            :....         |||.||        :||...|...|...
  Rat  1652 NKYASFFSLHLLEYKELKGDGPFTIFVPHSDLISNMSQGELARMRAHRQLVFRYHVLGCRKLGSQ 1716

  Fly   946 ----EGICTCSKQYKLHRNEDD-----NNLICLPICEPECLNGLCEF------PGSCVCWDGES- 994
                :|..|....:.|..:|.:     |:...:...:.|.:||:..|      |...:.|:.::
  Rat  1717 ELLDQGYVTALSGHTLRISEREGSIYLNDFARVVSSDHEAVNGVLHFIDRVLLPPDVLHWEADTI 1781

  Fly   995 PI 996
            ||
  Rat  1782 PI 1783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eater	NP_651533.3	None
Stab1	XP_008769275.1	Fasciclin	391..494	CDD:295423
		Fasciclin	523..647	CDD:280607
		EGF_3	834..863	CDD:289699	10/35 (29%)
		EGF_3	918..949	CDD:289699	9/36 (25%)
		EGF_3	955..991	CDD:289699	10/35 (29%)
		Fasciclin	<1100..1180	CDD:280607	4/79 (5%)
		Fasciclin	1224..1313	CDD:295423	7/88 (8%)
		EGF_3	1519..1555	CDD:289699	16/47 (34%)
		EGF_3	1561..1595	CDD:289699	15/34 (44%)
		EGF_3	1604..1641	CDD:289699	15/48 (31%)
		Fasciclin	1666..1770	CDD:280607	18/103 (17%)
		Fasciclin	1796..1926	CDD:280607
		EGF_Lam	2037..2082	CDD:238012
		EGF_3	2154..2189	CDD:289699
		EGF_3	2195..2232	CDD:289699
		Link_Domain	2267..2359	CDD:295393
		FAS1	2426..2521	CDD:214719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900