DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nep5 and ECE2

DIOPT Version :9

Sequence 1:NP_733186.2 Gene:Nep5 / 43255 FlyBaseID:FBgn0039478 Length:882 Species:Drosophila melanogaster
Sequence 2:NP_001093590.1 Gene:ECE2 / 9718 HGNCID:13275 Length:811 Species:Homo sapiens


Alignment Length:837 Identity:235/837 - (28%)
Similarity:399/837 - (47%) Gaps:146/837 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 SPNLIGIQSKFRRSYYHKVVLGGLLALVIILLIAII---VISLGLK----KSSSICRSKECLRTA 139
            |..::|.|...|:....:..|..:||...:||.|::   :::||::    .|.|.|.::.|:|.|
Human    85 SRTMVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA 149

  Fly   140 ASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDS----VTSNDWFRERQAHIMRVVREFLRSNIT 200
            ..::.::|....||||||||:||.|...:|.||.    .|.|..:.:.||    :::..|.:...
Human   150 GKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQA----ILKHLLENTTF 210

  Fly   201 KSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVK 265
            .|..||..|.:..|.:|:..:.:::...:||.:.:.:.|                     ..|:.
Human   211 NSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG---------------------GWNIT 254

  Fly   266 YNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPF-------NNDDSHKML 323
            ..|.|                     |.|...:..:|    .|..|.||       ::..|:..:
Human   255 GPWDQ---------------------DNFMEVLKAVA----GTYRATPFFTVYISADSKSSNSNV 294

  Fly   324 RKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEA 388
            .::.:..:|:.:.    |...:|.:.|:.        :||||.|:.::  ..||...|...:|: 
Human   295 IQVDQSGLFLPSR----DYYLNRTANEKV--------LTAYLDYMEEL--GMLLGGRPTSTREQ- 344

  Fly   389 TLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTDKNIAPKTLPI 450
                          .::|.|.:.:..|:|.|.....| :.:|  :::.:||     .:||..  .
Human   345 --------------MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-----ALAPSM--D 388

  Fly   451 WVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVL 515
            |:.::..:|      ..::::.:..::....|  |||.:.|.::.|..|.:.:||    |..||.
Human   389 WLEFLSFLL------SPLELSDSEPVVVYGMD--YLQQVSELINRTEPSILNNYL----IWNLVQ 441

  Fly   516 HTSSSM---------RLLHSEYMRVAIGTEGS-TPRSLYCANGVNSLLGMAVSYVLADADFTKEK 570
            .|:||:         :||.:.|     ||:.| .||...|.:..:..||.|:..:...|.|.::.
Human   442 KTTSSLDRRFESAQEKLLETLY-----GTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQS 501

  Fly   571 LPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEV 635
            ....|.|:|:||.:|:..:....|||..|::...:|:..:...||||.::.....|:..|:|.|:
Human   502 KEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEI 566

  Fly   636 NASTHLENLMDFVHWQ---MMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFY 697
            :..:..:|:::..::.   |.|:|.:  .|....|:.:|..|||::....|.|..|..|||.|||
Human   567 SEDSFFQNMLNLYNFSAKVMADQLRK--PPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFY 629

  Fly   698 DLG-LEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYH 761
            ... .:|||:|.||.::||||||.|||.||.:|:.||:..||.|.::..:.|.|.|..|||::|.
Human   630 ARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQ 694

  Fly   762 LADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLW 826
            :.  .|.::|..|||||||||||::.|:.||:.::::.|.|: :||.:...:| ||||:.|..:|
Human   695 VN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ-QLPAVGLTNH-QLFFVGFAQVW 755

  Fly   827 CETYTPAASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            |...||.:|...| ||.|.|.:.|:.|.||||.:|.|.|.|..|:||||.| .|.:|
Human   756 CSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQ-LCEVW 811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nep5NP_733186.2 PepO 146..882 CDD:226118 216/764 (28%)
M13 151..880 CDD:189000 214/757 (28%)
ECE2NP_001093590.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..64
M13 160..809 CDD:189000 214/758 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.020

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