Protein Alignment Nep5 and ECEL1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_004817.2
• Gene: ECEL1 / 9427
• HGNCID: 3147
• Length: 775
• Species: Homo sapiens
• Alignment Length: 855
• Identity: 228/855 - (26%)
• Similarity: 367/855 - (42%)
• Gaps: 150/855 - (17%)

  Fly    71 ANGKQLPYEPISP-----NLIGIQSKFRRSYYHKVVLGGLLALVIIL-LIAIIVISLGLKKSSSI 129
            |.|..||  |..|     :..|.:|...|....:|.|  |..||... |.||:...|.||....:
Human    28 ARGASLP--PGFPLGAARSATGARSGLPRWNRREVCL--LSGLVFAAGLCAILAAMLALKYLGPV 88

  Fly   130 ----------CRSKECLRTAASLIYA-MDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRER 183
                      |..::....||..:.| :|...|||:|||.|.||.|...|..||...:....
Human    89 AAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTI--- 150

  Fly   184 QAHIMRVVREFLRSNITKSEPEAVG----KAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLP 244
             |.|.....|.||..:.:......|    |.:..:|:|:|.:.:::....|:        |.|:.
Human   151 -AAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPM--------LEVIE 206

  Fly   245 SALNLTLGSGSKYATEAANVKYNWL----QSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGT 305
            ......||...:....||....|.|    |.:.|..  ....|.:..|      :|..:|..:..
Human   207 DCGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAA--ALFSLTVSLD------DRNSSRYVIRI 263

  Fly   306 PETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRK 370
            .:.....|              .:|:::  :.|||..:.                :.||..::.:
Human   264 DQDGLTLP--------------ERTLYL--AQDEDSEKI----------------LAAYRVFMER 296

  Fly   371 VIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDI------VY 429
            |:.  ||..|                    .|.:|..|..:..:.:...:.:..||:      :|
Human   297 VLS--LLGAD--------------------AVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMY 339

  Fly   430 --ITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEY 492
              :||..||     .|.|...  |...::.|.:.       ..::...::....|  |:|.:.:.
Human   340 NKVTLGQLQ-----KITPHLR--WKWLLDQIFQE-------DFSEEEEVVLLATD--YMQQVSQL 388

  Fly   493 LDDTPASHIESYLFLSTIEELVLHTSSSMR-LLHSEYMRVAIGTEGS-TPRSL--YCANGVNSLL 553
            :..||...:.:||....:..|..|.|...| .||    .:|...||| .|:.|  .|....|...
Human   389 IRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALH----ELAQEMEGSDKPQELARVCLGQANRHF 449

  Fly   554 GMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPP 618
            |||:..:.....|:.....||::::.||:....:.::...||||.|:.....|...|...:|:|.
Human   450 GMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPD 514

  Fly   619 WLRNASVLNAYYEGAEVNASTHLENLMDFVHWQM---MDKL-NEMDKPEPIGWATSPSNVNAFHT 679
            :|.....::..|| .||:..|:.:|:::.:.:.:   :.|: .|:||..   |...|..:||::.
Human   515 FLLKPDAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKST---WLLPPQALNAYYL 575

  Fly   680 FQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTI 743
            ...|.:..|..|||...||... ::||||.||||:|||||||:||.|.::||:||::.||:..:.
Human   576 PNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASY 640

  Fly   744 DEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPG 808
            ..::.:.||.|..|..:.:  .::.::|:.||||||||.||::.|::||:.:|:|.|.|. .||.
Human   641 SRFLRKAECIVRLYDNFTV--YNQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEH-PLPR 702

  Fly   809 LEHYSHEQLFFISFGNLWC-ETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPM 872
            |: |:|:|||||:|...|| :..:.:.....|||.|.|...|:.|.:|..|||.|.|.|.:.:||
Human   703 LK-YTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPM 766

  Fly   873 NPDQPKCRIW 882
            ||.. ||.:|
Human   767 NPAH-KCSVW 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	201/754 (27%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	201/755 (27%)