Protein Alignment Nep5 and Ece1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 838
• Identity: 229/838 - (27%)
• Similarity: 390/838 - (46%)
• Gaps: 143/838 - (17%)

  Fly    81 ISPNLIGIQSKFR-----------RSYYHK--VVLGGLLALVIILLIAIIVISLGLK---KSSSI 129
            :.||  |:|..||           |:...|  |||..|||..::..:|    :||::   ::..:
  Rat    39 VYPN--GLQVNFRSPRSGQRCWAARTSVEKRLVVLVTLLAAGLVACLA----ALGIQYRTRTPPV 97

  Fly   130 CRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREF 194
            |.::.|:...:|::.:||...|||:||:.:.||.|...:|.||..:....|.....|...:::..
  Rat    98 CLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHL 162

  Fly   195 LRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYAT 259
            | .|.|.|..||..||:..|||||:...:::...:||:..:.:.|      ..|:|    ..:|
  Rat   163 L-ENSTASASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLG------GWNIT----GPWA- 215

  Fly   260 EAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRI-----ALGTPETDSAFPFNNDDS 319
                 |.|:..::..:..|..........|..|..|...|.|     .||.|..|  :..|..::
  Rat   216 -----KDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD--YYLNKTEN 273

  Fly   320 HKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLL------Y 378
            .|:|                                      |.||:|:.::.:  ||      .
  Rat   274 EKVL--------------------------------------TGYLNYMVQLGK--LLGGGDEDS 298

  Fly   379 VDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTD 440
            :.|.:.|                    :.:|:....|:|.|.:...| :::|  :|..:||
  Rat   299 IRPQMQQ--------------------ILDFETALANITIPQEKRRDEELIYHKVTAAELQ---- 339

  Fly   441 KNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYL 505
             .:||..  .|:.::..|..      .:::.::..|:.  .|..||:.:...::.|....:.:|:
  Rat   340 -TLAPAI--NWLPFLNAIFY------PVEINESEPIVV--YDKEYLRQVSTLINSTDKCLLNNYM 393

  Fly   506 FLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGS-TPRSLYCANGVNSLLGMAVSYVLADADFTKE 569
            ..:.:.:.........:....::|.|..||:.: .||..:|.:...:.||.|:..:...|.|.::
  Rat   394 MWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAED 458

  Fly   570 KLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAE 634
            .......::.:|:::|:..:.:..|||..|:|...:|:..:.:.||:|.::.:...|:..:....
  Rat   459 SKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYT 523

  Fly   635 VNASTHLENLMDFVH--WQM-MDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPF 696
            .....:.||.|.|.:  |:: .|:|.:  .|....|:.:|..|||:::...|.|..|..|||.||
  Rat   524 AVPDLYFENAMRFFNFSWRVTADQLRK--APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPF 586

  Fly   697 YDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY 760
            |.... .|||:|.||.::||||||.|||.||.:|:.||:..||.|.:::.:..:|||.|:||:.|
  Rat   587 YTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNY 651

  Fly   761 HLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNL 825
            .:.  .|.::|..|||||||||||::.|:.||:.:||:.|.|:. ||.|...|: ||||:.|..:
  Rat   652 SVN--GEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEQI-LPTLGLTSN-QLFFLGFAQV 712

  Fly   826 WCETYTPAASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            ||...||.:|...| ||.|.|.:.|:.|.||||:||:..|:|..|:|||| :.||.:|
  Rat   713 WCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNP-RHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	205/748 (27%)
Ece1	XP_006239337.1	M13	118..767	CDD:341056	205/749 (27%)