Protein Alignment Nep5 and MMEL1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 836
• Identity: 237/836 - (28%)
• Similarity: 395/836 - (47%)
• Gaps: 139/836 - (16%)

  Fly   103 GGLLALVIILLIAIIVISLGL-------------------------------------KKSSSIC 130
            |||  |:::||:...:::||:                                     ::.|.:|
Human    27 GGL--LLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVC 89

  Fly   131 RSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFL 195
            .:..|:..||.::..||..|:||:|||||.||.|...|..|::.:....|...:..:..:::..|
Human    90 TTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVL 154

  Fly   196 RSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYL-LRFGLPVLPSALNLTLGSGSKYAT 259
            .::..|..| ||.||:|:||:||:..:::||..:||::.| :..|.||.....|.|:|...:...
Human   155 ENSTAKDRP-AVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELER 218

  Fly   260 EAA--NVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRT-----INRIALGTPETDSAFPFNND 317
            :.|  |.::|         :.:.:||.|    :.|..|.:     |::..||.|..:..|   |.
Human   219 QLALMNSQFN---------RRVLIDLFI----WNDDQNSSRHIIYIDQPTLGMPSREYYF---NG 267

  Fly   318 DSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPN 382
            .|::.:|:                                     |||.::..|..  ||..|.|
Human   268 GSNRKVRE-------------------------------------AYLQFMVSVAT--LLREDAN 293

  Fly   383 VNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVY---ITLQDLQNQTD-KNI 443
            :.::..      ||::.:   .:|.|.:.:....|.|.:...|.|..   :.|::||:|.. |..
Human   294 LPRDSC------LVQEDM---VQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGF 349

  Fly   444 APKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLS 508
            .      |..:::.:|...:    |::..:..::.  ..|.||||:...:|...|..|::||...
Human   350 N------WTLFIQTVLSSVK----IKLLPDEEVVV--YGIPYLQNLENIIDTYSARTIQNYLVWR 402

  Fly   509 TIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPK 573
            .:.:.:...|...:.....|.:...||.....|...|...|||.:..||..:.....|..:....
Human   403 LVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSM 467

  Fly   574 VERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNA--SVLNAYYEGAEVN 636
            |..::..:|..|...:....|||..:|:|..:|:..::..||.|.::...  ..|:..|.....:
Human   468 VRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFS 532

  Fly   637 ASTHLENLMDFVHWQMMDKLNEM-DKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLG 700
            ...:.||.:..:.......|.:: :|.:|..|....:.||||::...|.|..|..|||.||:...
Human   533 EDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKE 597

  Fly   701 L-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY--HL 762
            . :|||:|.||.::|||:||||||:||.||:.|||::||||.:...:..::||.:.||..|  .|
Human   598 QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDL 662

  Fly   763 ADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWC 827
            || ::.::|..|||||||||||:|:|:.||..::.|.|::: :||||: .:|||||||::..:||
Human   663 AD-EQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQ-QLPGLD-LTHEQLFFINYAQVWC 724

  Fly   828 ETYTPA-ASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .:|.|. |.:...||.|.|.:.|:.|.|.|...||.||.|||||||:|.: :||:|
Human   725 GSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKE-RCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	218/747 (29%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	218/746 (29%)