DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and ece1

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	805	Identity:	229/805 - (28%)
Similarity:	388/805 - (48%)	Gaps:	130/805 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LLALVIILLIA--IIVISLGLKKSSS---ICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRW 164
            |:.||..|.:|  |.::||||....|   :|.|:.|:..|::::.::|...|||:|||.|.||.|
Zfish    51 LVVLVCALSVALFICIVSLGLHYKESHPGLCLSEPCVSVASAVLGSLDRSVDPCQDFYNFACGGW 115

  Fly   165 ANEHPRPDSVT-----SNDWFRERQAHIMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLD 224
            ..::|.|:..:     ||.|     .|.|.|::..|.:...||...|..||:..|:|||:...::
Zfish   116 MRKNPLPEGKSRWGPFSNLW-----EHNMAVMKNLLENTSMKSLSRAEQKAQWYYQACMNESKIE 175

  Fly   225 KRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDV 289
            :...:|            |...:|.|.|.|.|...|..|     .|.::
Zfish   176 ELGAKP------------LQDLINQTGGWGLKGPWEKDN-----FQEVL---------------- 207

  Fly   290 FPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEE-EA 353
                      ||......|...|                 |:|:        |.|.:.|... ..
Zfish   208 ----------RIVSANFRTSPFF-----------------TVFV--------STDSKSSNSNIIQ 237

  Fly   354 AKQTSTGMTAYLHYVRKVI-EKYLLYVDPNVNQEEATLGITELVKQGV----------RVARKVH 407
            ..|:..|:.:..:|:.|.. ||||          .|.|..  ||:.||          ::..::.
Zfish   238 VDQSGLGLPSREYYLNKTANEKYL----------NAYLNF--LVELGVLLGGSQDTSQKMMEEII 290

  Fly   408 EFKEEAENMTKPSKNPAD-DIVYITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMT 471
            ||:....|:|.|.....| :.:|..:|..:..|   :||..  .|:.::..:.      ..:::.
Zfish   291 EFETTLANITVPQVERRDEEKIYYKIQAKELAT---LAPAI--DWMPFLSSVF------APVELN 344

  Fly   472 QNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTE 536
            .:..::....:  |||.:.|.:.:|..|.:.:|:.:..:.::|.......:.....::.|..||:
Zfish   345 NSEPVVVYAKE--YLQKVSELISNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFLEVMYGTK 407

  Fly   537 GS-TPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATK 600
            .| .||...|.:..:|.||.|:..:...|.|:::....||.|:|:|:.:|:..:|:.||||..||
Zfish   408 KSCMPRWKLCVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSEIKWAFEDSLKTVSWMDPETK 472

  Fly   601 RKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDK-PEP 664
            :...:|:..:.:.:|:|.::.|...|:..:...:|.:..:.:|:|::.::......:::.| |..
Zfish   473 KAAKEKADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRKAPNR 537

  Fly   665 IGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRF 728
            ..|:.:|..|||::....|.:.:|..|.|.|||:... :|:|:|.||.::||||||.|||.||::
Zfish   538 DQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQGRKY 602

  Fly   729 DRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYR 793
            |:.||:.:||.|.:::.:.::|:|.|||||.|.:.  :|.::|:.|||||||||||:..|:.||.
Zfish   603 DKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSIN--NEPLNGKHTLGENIADNGGLNAAYKAYV 665

  Fly   794 LYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRY-ALTDSHCPGQMRLRGVLSNS 857
            .::|:.|.|.| ||.|...:| ||||:.|..:||...||.:|.. .:||.|.|.:.|:.|.:|||
Zfish   666 NWIKKNGEEAS-LPALGMNNH-QLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTISNS 728

  Fly   858 EEFARTFKCARGTPMNPDQPKCRIW 882
            .||:..|.|...:||||.: ||.:|
Zfish   729 HEFSEHFGCKADSPMNPKR-KCELW 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	213/757 (28%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	211/750 (28%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	213/760 (28%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	211/751 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020