DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and PHEX

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	813	Identity:	227/813 - (27%)
Similarity:	395/813 - (48%)	Gaps:	118/813 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 VVLGGLLAL-VIILLIAIIVISLGLKKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGR 163
            |.:||.|.| .|:.|::..::||..|:  ..|...||:..||:::..::...|||::|::|.|..
Human    25 VFVGGTLVLGTILFLVSQGLLSLQAKQ--EYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDG 87

  Fly   164 WANEHPRPDSVTS---NDWFRERQAHIMRVVREFLRSNIT-KSEPEAVGKAKTMYRACMDTKLLD 224
            |.:.:|.|:.:.|   ..|.|.   ::...::|.|..:|: :.:.||:.|||.:|.:||:.|.::
Human    88 WISNNPIPEDMPSYGVYPWLRH---NVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIE 149

  Fly   225 KRDLEPLINYLLR---FGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIG 286
            |.|.:||: ::||   |..|||.|    .:|....::..    |::.||::.:.:...:..:.|.
Human   150 KADAKPLL-HILRHSPFRWPVLES----NIGPEGVWSER----KFSLLQTLATFRGQYSNSVFIR 205

  Fly   287 FDVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEE 351
            ..|.||                |.|       |::.:.|:.:.|:.:...:|..|:..:.:|
Human   206 LYVSPD----------------DKA-------SNEHILKLDQATLSLAVREDYLDNSTEAKS--- 244

  Fly   352 EAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFK------ 410
                            .|..:.|::               :...|..|...:|..|:.|
Human   245 ----------------YRDALYKFM---------------VDTAVLLGANSSRAEHDMKSVLRLE 278

  Fly   411 -EEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPI----WVRYMELILKGTR---HAGN 467
             :.||.|. |.:|...:.:|         ...||:..:..|    |:.|::.:: .||   |..:
Human   279 IKIAEIMI-PHENRTSEAMY---------NKMNISELSAMIPQFDWLGYIKKVI-DTRLYPHLKD 332

  Fly   468 IQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVA 532
            |..::|:.:...|    |.:::...|.......|.:||....:...:.:.|...:....|:.||.
Human   333 ISPSENVVVRVPQ----YFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVI 393

  Fly   533 IGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSF-DRLVKSTSWMD 596
            .||....|:...|.|.:.|.|...|..:..|..|.::|...:|.::..:|.:| |.|.|...|||
Human   394 QGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKENEWMD 458

  Fly   597 AATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDK 661
            |.||||..:|:..:.:.:|:|.::.|.:.:|...:..:.:.:.:..|::....:........:.|
Human   459 AGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRK 523

  Fly   662 PEP-IGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGLE---ALNYGSIGTILGHELTHGFD 722
            ..| ..|.|:|:.||||::..:|.|..|...||.||: .|.|   :|:||:||.|:|||.|||||
Human   524 AVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFF-WGTEYPRSLSYGAIGVIVGHEFTHGFD 587

  Fly   723 DSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMRE 787
            ::||::|:.||:..|||..:.:::..:|:|.:.|||.|:.......:.|:.|||||||||||:||
Human   588 NNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLRE 652

  Fly   788 AFYAYRLYV--KEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSHCPGQMR 849
            ||.|||.::  :..|.|...|||:. :::.||||:|:.::.|.:|.|.|:|..: ..:|.|.|.|
Human   653 AFRAYRKWINDRRQGLEEPLLPGIT-FTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFR 716

  Fly   850 LRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            :.|.:||.|||.:.|.|...:.||.....||:|
Human   717 VNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	211/764 (28%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	209/757 (28%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	209/758 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920