DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nepl20

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	819	Identity:	214/819 - (26%)
Similarity:	338/819 - (41%)	Gaps:	224/819 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 KECLR--TAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFL 195
            ||.:|  .||.:...|:::.|||:|||.|:||.:.               |...|..|||:...:
  Fly    37 KELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYK---------------RINSALNMRVLTTGV 86

  Fly   196 RSNITK-----------------SEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFG-LPV 242
            ...:||                 ..||.: :.|..|.:|:..|.|:....|.|...:..|| :|:
  Fly    87 FETLTKGLNRKILKMLNTPHDSHDTPEDI-QVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPL 150

  Fly   243 LPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPE 307
            |         .||.:..:    .::||.:...:.....:..|||..|..|..|...|.|.:...|
  Fly   151 L---------EGSSWQED----DFDWLNTTARMAHRYGIMSIIGVGVATDFANNQKNIIYINQQE 202

  Fly   308 TDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVI 372
                ||            :..::::|.|                    :|:.....|.:.::.::
  Fly   203 ----FP------------LKTRSMYMDN--------------------ETAIYRQNYQNNIQLIL 231

  Fly   373 EKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEE-AENMTKPSK--NPADDIVYITLQD 434
            ||||...|             ||.:   :.|:::.||:.: |..:...:|  |..|.|..:|:.:
  Fly   232 EKYLGVKD-------------ELAR---KAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAE 280

  Fly   435 LQNQ------TDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYL 493
            |:.:      ||               :||.        :.|.:.::....:.:..|.||:||.:
  Fly   281 LRERYAPTLDTD---------------QLIF--------VSMGEKISDKVYEYNRRYQQNLVEVI 322

  Fly   494 DDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVS 558
            :.||.|.:.:||||..|.|.:...|                                   |:|..
  Fly   323 ERTPKSTVANYLFLRLIWEFIQKPS-----------------------------------GVAEK 352

  Fly   559 YVLADADFTKEKLPK------------------VERMLSDIRRSFDRLVKST---SWMDAATKRK 602
            ...|..||||....|                  ::.|...::.:|...:.|:   .|::.:|:..
  Fly   353 PTEACVDFTKTYFAKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSL 417

  Fly   603 TIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTH--LENL--MDFVHWQMMDKL-NEMDKP 662
            .|.|...|...:      .|....|...|.|::|....  :|||  :..:..:.|.:| ::..||
  Fly   418 AIAKLEAMTLEV------NNYVKENFTEEFADLNLQNTDCVENLRQVQMLQAKQMRQLYHQPAKP 476

  Fly   663 EPIGWATS--PSNVNAFHTFQSNAITVPIAILQYPFY---DLGLEALNYGSIGTILGHELTHGFD 722
            ...|...|  |||:     ...|:|.||:|:|| |||   |:...|:.:|::..::||||.||||
  Fly   477 LEAGELLSYTPSNI-----LLENSIKVPVALLQ-PFYIWSDVYPNAVMFGTLAYLIGHELIHGFD 535

  Fly   723 DSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMRE 787
            ||||:||..||..:||..::...::.|.:||.:||.||....|.  :.......||||||||||.
  Fly   536 DSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQ--LKESTAQSENIADNGGMRL 598

  Fly   788 AFYAYR------LYVKEVGRERSK--LPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSH 843
            |:.|||      |.:....::.:|  ||.| .|:.:|||||||...||....|......: ||.|
  Fly   599 AYTAYRKWYENQLTLPNGAQDMTKETLPNL-RYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDH 662

  Fly   844 CPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .||:.|:.|.|||.|||::.|.|..|:.|||.: ||.::
  Fly   663 MPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIE-KCILY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	209/802 (26%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	207/795 (26%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	204/794 (26%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	206/795 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920