DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nepl18

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	794	Identity:	181/794 - (22%)
Similarity:	314/794 - (39%)	Gaps:	222/794 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 MDEQTDPCEDFYQFTCGRWANEHPRP---DSVTSNDWFRERQAHIMRVVREFLRSNITKSEPEAV 207
            |..:..||:|||...||.|...:|..   |.:|.|  |:.......|.::..||:|..:||.|
  Fly    54 MKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDN--FKLISKGFDRRLQRLLRANDLQSELE-- 114

  Fly   208 GKAKTMYRACMDTKLLDKRDLE---PLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWL 269
               |.|.|..|...|:.:.|:.   .|.|.:..:|  .||:.:.....|..          ::|.
  Fly   115 ---KKMQRFYMSCNLVHRDDVHYKLALENVIREYG--TLPALVGAQWNSSD----------FSWW 164

  Fly   270 QSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQ 334
            :::..|:......:|||.::..|..|.::||:.:..|:.                    |||
  Fly   165 RTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDF--------------------KTI--- 206

  Fly   335 NSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKV--IEKYLLYVDPNVNQEEATLGITELVK 397
                                   :|.:|..:..||..  :::|              .|::..|.
  Fly   207 -----------------------NTRLTNLMEEVRTSMDLQQY--------------FGLSSSVA 234

  Fly   398 QGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPIWVRYMELILKGT 462
            :  ..|.::.|.:....:....:....:.:...|:.|||.:...::.      :..::.|||
  Fly   235 K--HTAEQLTELERTFSSGGSGAATLQESLSLYTVADLQEKYSDHLN------FTEFLGLIL--- 288

  Fly   463 RHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSE 527
               |...:.::|.|.    |..||...:..:..||.:...:|:....:|:.::
  Fly   289 ---GEENIPKSLYIY----DEEYLDKALLTMRSTPLATQANYVLWKLLEDFLV------------ 334

  Fly   528 YMRVAIGTEGSTPRSL--YCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDR--- 587
                     .:.|:.:  :|........|....:    |.:.:.:.|.||   |::.:.:|:
  Fly   335 ---------DAQPKDMVKWCTESTKKYFGKLAEH----AVYKRYRNPDVE---SEVHKIWDQIKG 383

  Fly   588 ------LVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMD 646
                  |.....|:..||:...|:|...|...|            |:|.|       .:.||:..
  Fly   384 IFRQRLLGDKLDWISNATRTLAIEKLERMHLNI------------NSYDE-------ENFENVYG 429

  Fly   647 FVHWQMMDKLN-------------------------EMDKPEPIGWATSPSNVNAFHTFQSNAIT 686
            .|   .:|:||                         .:|..|.:|:..:       :..|.|.||
  Fly   430 EV---FIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATELLGFTPA-------YNIQENNIT 484

  Fly   687 VPIAILQ--YPFYDLGLEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNR 749
            :|:|:||  |.:.|...|||.|.::|.:|.||:.|||||.||::|.:||:..||..::..|:..|
  Fly   485 IPVALLQPRYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEER 549

  Fly   750 TECFVEQYSRYHLADIDEYIDGEL----TLGENIADNGGMREAFYAYRLYVKEVGRE---RSKLP 807
            .:||..||..|      :|...:|    ...|||||:||::.|:.||.|::.:...|   |..:.
  Fly   550 RKCFQAQYHEY------QYGGSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEEVLQRETME 608

  Fly   808 GLEHYSHEQLFFISFGNLWCE----TYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCAR 868
            ||. ::..||||:.:..|.|:    .:.|..|:   :|.|.|.:.|:.|.|||.:||...|.|::
  Fly   609 GLP-FNSRQLFFLGYAQLLCDDVQFLFQPWVSQ---SDRHAPSKYRVIGPLSNFQEFPWVFNCSQ 669

  Fly   869 GTPMNPDQPKCRIW 882
            ..||:|:. ||.|:
  Fly   670 SAPMDPEY-KCAIY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	180/792 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	178/785 (23%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	180/792 (23%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	177/785 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870