Protein Alignment Nep5 and MME

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_000893.2
• Gene: MME / 4311
• HGNCID: 7154
• Length: 750
• Species: Homo sapiens
• Alignment Length: 815
• Identity: 249/815 - (30%)
• Similarity: 395/815 - (48%)
• Gaps: 132/815 - (16%)

  Fly   105 LLALVIIL-LIAIIVISLGLKKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEH 168
            |..||::| :||:.:|:|.......||:|.:|:::||.||..||..|:||.||:::.||.|...:
Human    31 LSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRN 95

  Fly   169 PRPDSVTSNDWFRERQAHIMRVVREFLRSNITKSEPE-----AVGKAKTMYRACMDTKLLDKRDL 228
            ..|:  ||:   |.....|:|...|.:..::.: ||:     ||.|||.:||:|::...:|.|..
Human    96 VIPE--TSS---RYGNFDILRDELEVVLKDVLQ-EPKTEDIVAVQKAKALYRSCINESAIDSRGG 154

  Fly   229 EPLINYLLR-FGLPVLPSALNLTLGSGSKYATEAA----NVKYNWLQSIVSIKQHLTMDLIIGFD 288
            |||:..|.. :|.||  :..|.....|:.:..|.|    |.||.         :.:.::|.:|.|
Human   155 EPLLKLLPDIYGWPV--ATENWEQKYGASWTAEKAIAQLNSKYG---------KKVLINLFVGTD 208

  Fly   289 VFPDPFNRTINRI------ALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRE 347
                 ...::|.:      .||.|..|          :.....|:::
Human   209 -----DKNSVNHVIHIDQPRLGLPSRD----------YYECTGIYKE------------------ 240

  Fly   348 SEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEE 412
                        ..|||:        .:::.|...:.||| .|.|.|  .|......||.|.::|
Human   241 ------------ACTAYV--------DFMISVARLIRQEE-RLPIDE--NQLALEMNKVMELEKE 282

  Fly   413 AENMT-KPSKNPADDIVY--ITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNL 474
            ..|.| ||.......::|  :||..:||.....|..|... |:.:          ...|..|.|:
Human   283 IANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFS-WLNF----------TNEIMSTVNI 336

  Fly   475 TIITSQADIT-----YLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIG 534
            : ||::.|:.     ||..:...|....|..:::.:....|.:||...|.:.:...:.:.:...|
Human   337 S-ITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYG 400

  Fly   535 TEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAAT 599
            |...|.....|||.||..:..||..:..:|.|..|....||.:::.||..|.:.:...:||||.|
Human   401 TTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAET 465

  Fly   600 KRKTIQKSAEMKSFIGFP-PWLRNASVLNAYYEGAEVNASTHLENL---MDFVHWQMMDKLNE-M 659
            |::..:|:..:|..||:| ..:.|.:.||..|.........:.||:   :.|...:.:.||.| :
Human   466 KKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKV 530

  Fly   660 DKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDL-GLEALNYGSIGTILGHELTHGFDD 723
            ||.|   |.:..:.||||::...|.|..|..|||.||:.. ...:||||.||.::|||:||||||
Human   531 DKDE---WISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDD 592

  Fly   724 SGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY--HLADIDEYIDGELTLGENIADNGGMR 786
            :||.|::.|::|:||:.::...:..:::|.|.||..:  .||. .::::|..|||||||||||:.
Human   593 NGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAG-GQHLNGINTLGENIADNGGLG 656

  Fly   787 EAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL----TDSHCPGQ 847
            :|:.||:.|:|:.|.|: .||||: .:|:||||::|..:||.||.|   .||:    ||.|.||.
Human   657 QAYRAYQNYIKKNGEEK-LLPGLD-LNHKQLFFLNFAQVWCGTYRP---EYAVNSIKTDVHSPGN 716

  Fly   848 MRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .|:.|.|.||.||:..|.|.:.:.|||:: |||:|
Human   717 FRIIGTLQNSAEFSEAFHCRKNSYMNPEK-KCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	227/764 (30%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	227/763 (30%)