DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nepl14

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_651097.1	Gene:	Nepl14 / 42700	FlyBaseID:	FBgn0039023	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	171/826 - (20%)
Similarity:	295/826 - (35%)	Gaps:	235/826 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 KKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRER-QAHI 187
            :...::.|||     |..:...:::..|||.|||.:.||.|.:      ::|.....::: ...:
  Fly    39 QSEQTVRRSK-----AQDMGSHVNKSIDPCVDFYAYACGNWKS------TLTPQQQLQQQTDREL 92

  Fly   188 MRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRF-----GLPVLPSAL 247
            :.:|.|.:|    :.:...|.:||.::::|:..:....:..:   ::|..|     |.|.:|
  Fly    93 LLLVEEAVR----REDSVIVRQAKELFKSCVSAQAHQSQQQQ---HFLSEFINQNGGFPAVP--- 147

  Fly   248 NLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAF 312
                  ||::|..  :..||||..:..::....||::||..|..:..|...|.:.|..|.|
  Fly   148 ------GSQWAVH--HHDYNWLSVLGGLRLRYGMDILIGLRVGYNYGNVNENSLYLSEPST---- 200

  Fly   313 PFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLL 377
                        .|..:......||..|...:..|                  |.|...::.:|
  Fly   201 ------------LIPTELCTRNRSDIRDSIYEPLE------------------HRVASELKSWL- 234

  Fly   378 YVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKN---PADDIVYI------TLQ 433
                       .||..|    ..|:|..:..|:.|.....|....   .|::.:|:      ||:
  Fly   235 -----------ALGHDE----SARLAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLR 284

  Fly   434 DLQNQTDKNIAPKT---------LPIWVRYMELI--LKGTRHAGNIQMTQNLTIITSQADITYLQ 487
            :..|..:.::....         .|:::...|..  ||.|..|.||.:..|..:..:.:.:.:
  Fly   285 EFSNSIELDLDSYVRASFGQDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNF-- 347

  Fly   488 NIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSL 552
                .|||.|..                                         |...|......|
  Fly   348 ----PLDDRPQL-----------------------------------------RKRECLERTKEL 367

  Fly   553 LGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFP 617
            |..|:..:.|....|::....::.:...::.:. |......|:...|:|...:|
  Fly   368 LPTALGELYARQFGTEDGRIDLDNLYDTLKTAL-RQSLGAEWLVEGTQRVGQEK----------- 420

  Fly   618 PWLRNASVLNAYYEGAEV--------NASTHLENLMDFVHWQMMDKLNEMDKPEPIGWATSPSNV 674
              |||..:....||...:        |...:|..|:..|..|..::|.|...|.|    |.|  |
  Fly   421 --LRNLKLQMPTYERPVILKLQLERGNYWQNLRQLLGVVQSQRNNRLFEEFLPAP----TDP--V 477

  Fly   675 NAFHTF-----QSNAITVPIAILQYPFYD--LGLEALNYGSIGTILGHELTHGFDDSGRRFDRAG 732
            .|:...     ....:.:.:|:||.|.||  .| .|:.|.::|..|..:|...|||.
  Fly   478 EAYEARVRLRPVQRRLDMGLALLQPPAYDPRYG-HAIRYATLGVQLAQQLVMAFDDP-------- 533

  Fly   733 NMVEW---------WSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELT-LGENIADNGGMRE 787
               .|         |..:|..:|..|:.||..|        :|.|:...:: ..:.|.|:..:..
  Fly   534 ---HWSVGLLERDNWDGQTAWQYHIRSNCFARQ--------VDNYLRPNVSATTQLITDSAAINV 587

  Fly   788 AFYAYRLYV--KEVGRERSK-----LPGLEHYSHEQLFFISFGNLWC---------ETYTPAASR 836
            ||.||..::  :|...:.:|     ||.| :||:..|||:::....|         |..||....
  Fly   588 AFRAYLTWLGFQEPNNDFTKLTKETLPDL-NYSNTALFFLAYAQEHCSLEEARPRDEQGTPEGYL 651

  Fly   837 YALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            |:...:|...::.:.|.|.||.|||..|:|..|:|||| ..||.|:
  Fly   652 YSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNP-ASKCIIY 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	166/802 (21%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	165/795 (21%)
Nepl14	NP_651097.1	M13	60..693	CDD:189000	164/795 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920