DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nepl12

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_649924.1	Gene:	Nepl12 / 41172	FlyBaseID:	FBgn0037727	Length:	702	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	196/855 - (22%)
Similarity:	328/855 - (38%)	Gaps:	236/855 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LALVIILLIAIIVI---------SLGLKKSSSICRSKECLRTAASL---IYA------MDEQTDP 152
            |.|:.::|:.:||.         ||..:..:|........|:||..   .||      |::..:|
  Fly     6 LKLISLMLLWVIVAAVLTDCEARSLVDRSENSDSNGSSTNRSAAEYQLQEYAEFMKSYMNQSVEP 70

  Fly   153 CEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFL-RSNITK----SEPEAVGKAKT 212
            ||:||::.||.:.|..|...|..|.....:....::.:..:.| |.::.:    |...||  |:.
  Fly    71 CENFYEYACGNYRNVKPDRYSPGSRSNLGDVTYTLIDITEQLLGRMDLAEALNVSSELAV--AQR 133

  Fly   213 MYRACMDTKLLDKRDLEPLINYLLRF--GLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSI 275
            .|.||:...|......:|....|:|.  |.|.:...           |.:|:|  :||:.....:
  Fly   134 FYNACLGANLHPFNAADPAYLSLIRSIGGFPAVDGD-----------AWKASN--FNWINMSAHL 185

  Fly   276 KQHLTMDLI------------------IGFD---VFPDPFNRTINRIALGTPETDSAFPFNNDDS 319
            ..:....||                  :|||   |..:..:|...|          ||..|.:..
  Fly   186 ANYGANGLIRETLQLRYPFEPYTKLPELGFDHIIVHEENISRNTTR----------AFRLNEERM 240

  Fly   320 HKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVN 384
            |..||..                     ...|:..::...|:.|:.   |..:|     :.|...
  Fly   241 HGYLRAF---------------------GLPEDRIREAIAGVFAFW---RDALE-----IPPQCE 276

  Fly   385 QEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD----DIVYITLQDLQNQTDKNIAP 445
                       |....|: ::|....|...|::....:..:    |..|:.|..:..:..|.:|
  Fly   277 -----------VFDPYRI-KRVFPQSEYYYNISWSGLHSTNKLFCDFYYVELDKVCARHRKAVA- 328

  Fly   446 KTLPIWVRY--MELI------LKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIE 502
                   .|  |:|:      ||..|:..|            ...:|..|
  Fly   329 -------NYLAMKLLYRFDPKLKAPRYQRN------------YCSVTLYQ--------------- 359

  Fly   503 SYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFT 567
                             |||.|.::               ||.||                 :|:
  Fly   360 -----------------SMRFLFNK---------------LYMAN-----------------NFS 375

  Fly   568 KEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIG----------FPPWLRN 622
            :.|..::..|:.::|:|..:.::...|:||.::.:.:.|.:.::..||          ....:.:
  Fly   376 EAKRLEMSEMVRELRKSLRKALEDADWLDAESRARALLKESRIQPRIGSFQDDALSDRIIREINS 440

  Fly   623 ASVLNAYYEGAEVNASTHLE---NLMDFVHWQMMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNA 684
            ..|:...|....:|.. ||.   |.....|:|   :|....||:.|   .:...|.|.:....|:
  Fly   441 LKVIEDRYAETNINLQ-HLVVQINRFSSRHFQ---ELTNDTKPQKI---LTGLQVGAGYYTPDNS 498

  Fly   685 ITVPIAILQYPFYDLGLE-ALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVN 748
            |.|...:::.|.|...|. :|.:|::|.|:||||.||||.:...||..|:|....|..:.....:
  Fly   499 INVMAGVVEPPIYQRHLPISLKFGTLGFIVGHELIHGFDTTSSYFDGNGHMESLLSEISQQALED 563

  Fly   749 RTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEV----GRER--SKLP 807
            |.||:::.|.:|.:.:|...::|:.||.||||||.|:|:|..|||.:.:::    |:||  ..:|
  Fly   564 RAECYMDYYGKYQVPEISRRVNGKTTLDENIADNSGLRQALTAYRSHRQQLLEHPGQERISDAMP 628

  Fly   808 GLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPM 872
            ||: .:.|||||:.|..|:|..|........|:|.|...|.|:.|||||||:|...:.|:.|:.|
  Fly   629 GLD-LTPEQLFFLGFAQLFCSHYEEEHYWKGLSDVHTFDQFRVLGVLSNSEDFFHAYNCSVGSGM 692

  Fly   873 NPDQPKCRIW 882
            .|....||:|
  Fly   693 RPGAKTCRLW 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	182/795 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	179/788 (23%)
Nepl12	NP_649924.1	M13	68..700	CDD:189000	179/789 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920