Protein Alignment Nep5 and Ece2

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: XP_038944493.2
• Gene: Ece2 / 408243
• RGDID: 1303039
• Length: 789
• Species: Rattus norvegicus
• Alignment Length: 842
• Identity: 218/842 - (25%)
• Similarity: 381/842 - (45%)
• Gaps: 167/842 - (19%)

  Fly    27 QPLPLQRLQTPGNL-SLLSAPIRANGSGNGNATANGHGQNSATESANGK----QLPYEPISPNLI 86
            ||.|..| :.|..| |.::..::..|||           .|..|....|    :||...:....|
  Rat    63 QPRPALR-RGPALLHSTMNVALQELGSG-----------GSMVEYKRAKLQDEELPEVTVEGRAI 115

  Fly    87 ------GIQSKFRRSY-YH---KVVLGGLLALVIILLIAIIV---ISLGLKKSSSICRSKECLRT 138
                  |.|.:.|:.: .|   ::||.||:.::..||:..:|   :........|.|.::.|:|.
  Rat   116 QDSLEVGSQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVQYHRDPVHSTCITEACIRV 180

  Fly   139 AASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDS----VTSNDWFRERQAHIMRVVREFLRSNI 199
            |..::.::|....||:|||||:||.|...:|.|..    .|.|..:.:.||    :::..|.::.
  Rat   181 AGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQNQA----ILKHLLENST 241

  Fly   200 TKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANV 264
            ..|..||..|.::.|.:|:..:.::|...:||.:.:.:.|                     ..|:
  Rat   242 FNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKIG---------------------GWNI 285

  Fly   265 KYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPF-------NNDDSHKM 322
            ...|.:                     |.|...:..:|    .|..|.||       ::..|:..
  Rat   286 TGPWDE---------------------DNFMEVLKAVA----GTYRAAPFFTVYVGADSKSSNSN 325

  Fly   323 LRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEE 387
            :.::.:..:|:.:.    |...:|.:.|:..|        |||.|:.::  ..||...|...:.:
  Rat   326 IIQVDQSGLFLPSR----DYYLNRTANEKVLA--------AYLDYMVEL--GMLLGGQPTSTRAQ 376

  Fly   388 ATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTDKNIAPKTLP 449
                           .::|.|.:.:...:|.|.....| :.:|  :::.:||     .:||..
  Rat   377 ---------------MQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQ-----TLAPSM-- 419

  Fly   450 IWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELV 514
            .|:.::..:|      ..:::..:..::....:  |||.:.|.::.|..|.:.:||    |..||
  Rat   420 DWLEFLSFLL------SPLELGDSEPVVVYGTE--YLQQVSELINRTEPSILNNYL----IWNLV 472

  Fly   515 LHTSSSM---------RLLHSEYMRVAIGTEGS-TPRSLYCANGVNSLLGMAVSYVLADADFTKE 569
            ..|:||:         :||.:.|     ||:.| |||...|.:..:..||.|:..:...|.|.::
  Rat   473 QKTTSSLDQRFETAQEKLLETLY-----GTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQ 532

  Fly   570 KLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAE 634
            .....|.|:|:||.:|:..:::..|||..|:....:|:..:...||||.::.....|:..|:|.|
  Rat   533 SKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPRELDDVYDGYE 597

  Fly   635 VNASTHLENLMDFVHWQ---MMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPF 696
            |:..:..:|:::..::.   |.|:|.:  .|....|:.:|..|||::....|.|..|..|||.||
  Rat   598 VSEDSFFQNMLNLYNFSAKVMADQLRK--PPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPF 660

  Fly   697 YDLG-LEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY 760
            |... .:|||:|.||.::||||||.|||.||.:|:.||:..||.|.::..:.|.|.|..|||::|
  Rat   661 YAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQY 725

  Fly   761 HLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISF 822
            .:.  .|.::|..|||||||||||::.|:.||:.::::.|.|: .||.:...:| ||||:.|
  Rat   726 QVN--GERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ-PLPAVGLTNH-QLFFVGF 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	185/700 (26%)
Ece2	XP_038944493.2	None