DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nep2

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	210/784 - (26%)
Similarity:	358/784 - (45%)	Gaps:	116/784 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 SSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRV 190
            |..:|.::||:.||::::..|..:.:||::||:|.||.:..|...||...|...|......:...
  Fly    80 SGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDKLQEQ 144

  Fly   191 VREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRF-GLPVLPSALNLTLGSG 254
            :::.:.:...::||:.......:|:|||:..|::....||:.....|. |.|::         .|
  Fly   145 LKDIITAERPETEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLI---------KG 200

  Fly   255 SKYATEAANVKYNWLQSIVSIK-QHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDD 318
            ..:   .|:..:.|.:.:...: ...:||.||.|.:..|..|.|...|.|             |.
  Fly   201 DSW---NADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDL-------------DQ 249

  Fly   319 SHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNV 383
            |...|                        |.|........|.:|||..|   :::..:|:   ..
  Fly   250 SSLAL------------------------SREYLVKGFNETLVTAYYKY---MVDIAVLF---GA 284

  Fly   384 NQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPS---KNPADDIVYITLQDLQNQTDKNIAP 445
            |::   |..|||:..        .||:....|::.|:   :|.::      |.:|:.......|.
  Fly   285 NRD---LAKTELLLS--------LEFEMALANISWPNEKRRNSSE------LYNLRTPAQLQAAY 332

  Fly   446 KTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTI 510
            ..:. ||.||..:|....:....:|. ||::      .::.:::.:.|..||...|.:|:|....
  Fly   333 PYVQ-WVDYMNALLPEGLNVAEDEMI-NLSV------PSFFEDLGKLLAKTPKRVIANYMFWRIH 389

  Fly   511 EELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNS-----------LLGMAVSYVLADA 564
            ...|...|...|....:|.....|.:....|...|.:...|           .||::|..:....
  Fly   390 GFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISVGSLYVGK 454

  Fly   565 DFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAY 629
            .|.|:.......|:::||..|:.::...:||||.||::...|...|.:.||:|..:.:...|.||
  Fly   455 HFHKDSKANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGYPDEMLDNEKLAAY 519

  Fly   630 YEGAEVNASTHLENLM-------DFVHWQMMDKLNEMDKPEPIGWA--TSPSNVNAFHTFQSNAI 685
            |...:::...:.|:.:       |:...::...:|:.|      |.  ..|:.||||::...|:|
  Fly   520 YAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTD------WVRHARPAIVNAFYSSLENSI 578

  Fly   686 TVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNR 749
            ..|..|||..|::... :.:|:|:||.::|||:||||||.||:||..||:.:||...|...|:.:
  Fly   579 QFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAK 643

  Fly   750 TECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSH 814
            .:|.:|||..|........::|..|.|||||||||::|::.|||.:.::.|.| :|||||: |:.
  Fly   644 AKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPE-AKLPGLD-YTP 706

  Fly   815 EQLFFISFGNLWCETYTPAASRYALTDS-HCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPK 878
            ||:|:::.|..||..|...:.:..:|.. |.|.:.|:.|.|||.::||:.|.|..|:||||.| |
  Fly   707 EQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQ-K 770

  Fly   879 CRIW 882
            |.:|
  Fly   771 CEVW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	203/762 (27%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	201/755 (27%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	201/756 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920