DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nepl9

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_609815.1	Gene:	Nepl9 / 35020	FlyBaseID:	FBgn0032613	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	143/820 - (17%)
Similarity:	252/820 - (30%)	Gaps:	308/820 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFL---------RS 197
            |:...::..|||:|||...||.:             |..:|..:.      :||         |.
  Fly    53 LVKIKNDSMDPCDDFYAHACGNF-------------DQTKEENSD------DFLPPYLYNKQDRM 98

  Fly   198 NITKSEPEAVGKAKT--------MYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSG 254
            |...:|   ||..:|        :|..|.      ||:...:..          |:.|.
  Fly    99 NFFTAE---VGNFETIPGRLISQLYTECR------KREERNVFT----------PTRLT------ 138

  Fly   255 SKYATEAANVKYNW---LQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNN 316
                       .:|   |..|..:.:|                           .|..|::||..
  Fly   139 -----------SHWERMLDEIPFLARH---------------------------KEVLSSWPFLK 165

  Fly   317 DDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVD- 380
            ....:  |:::.:..::..|                 |:..:.|:...||....:...|:..::
  Fly   166 HQWER--RRLYGQLNWIVLS-----------------AQLAAHGLPTLLHIYFALDTIYVSPMEE 211

  Fly   381 ---PNVNQEEATLG---------ITELVKQGVRVARKVHEFKEE-------AENMTKPSKNPADD 426
               |::...:::|.         ::.::...:||.  ..|.:.|       ::|....:..|.::
  Fly   212 LPCPSIADFQSSLSDVLEGRHHQVSRIISHEMRVL--CREMRGELPLVRSLSQNTRTNTSRPGEE 274

  Fly   427 IVYITLQDLQNQTDKNIAPKTLPIWVRYMELI------LKGTRHAGNIQMTQNLTIITSQADITY 485
                     |...|:|    |:..:.:|...:      |.|.|              ....|:..
  Fly   275 ---------QLLLDEN----TMDYFQQYFAALNFSEERLVGAR--------------KFPLDVEK 312

  Fly   486 LQNIVEYLDDTPASHIESYLFLSTIEEL----VLHTSSSM-RLLHSEY-----MRVAIGTEGSTP 540
            :....|.|..|....:.:|:.....|:|    ....|... ||||:||     :|..:..|
  Fly   313 ITQAWEVLRHTETRIVYNYVMWQAREQLRYPDCYRVSEEFERLLHAEYWQWHVLRRHLSRE---- 373

  Fly   541 RSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKR---- 601
                        :.:| ||.|....|.|.:..|:.|     |..:..|     |..:..|:
  Fly   374 ------------VALA-SYQLHTTRFQKLRRSKLSR-----RDWYGHL-----WPASVEKKELQV 415

  Fly   602 -KTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPEPI 665
             :.:|..||  :::       |.:.||..|||.::..::...||:.....|:....
  Fly   416 ARILQNHAE--NYL-------NITELNENYEGLKLEKNSFYANLLILRRAQLRHSF--------- 462

  Fly   666 GWATSP----SNVNAFHTFQSNAITVPIAILQYPFYDLGLEALNYGSIGTILGHELTHGFDDSGR 726
               .||    .:||....|..:.:...:..|..|.|.                :..|||.:
  Fly   463 ---VSPYVDEEDVNQPAYFLRHFLHFVLLSLHRPTYH----------------YYATHGLE---- 504

  Fly   727 RFDRAGNMVEWWSNRTI---DEYVNRTECFVEQYSRYHLADIDEYIDGELT-----LGENIADNG 783
                     .|..:|.:   |.:....:|...|..:::        |.:|.     ||.:
  Fly   505 ---------LWRESRLLLDTDGHYTAMDCLERQSFQHY--------DAKLAPIYRPLGSH----- 547

  Fly   784 GMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTP-AASRYALTDSHCPGQ 847
            .:.|.|..||.:...:......|.| |.::..:.|.:.:..|     .| ....||:....|..|
  Fly   548 EIAEIFQFYRSFQYSLTDYHFWLQG-ERFAFAETFVLDYFGL-----NPHRVLFYAVAQQLCNRQ 606

  Fly   848 MRL------RGVLSNSEEFARTFKCARGTPMNPDQPKCRI 881
            ..:      ||.: |..||...|||.....|||.. :|.|
  Fly   607 TEIFAAQLNRGYM-NLPEFQEAFKCGAEKAMNPPS-RCMI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	142/816 (17%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	140/808 (17%)
Nepl9	NP_609815.1	GluZincin	62..>84	CDD:301352	10/34 (29%)
Nepl9	NP_609815.1	GluZincin	<579..642	CDD:301352	18/69 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910