DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nepl7

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001285879.1	Gene:	Nepl7 / 34671	FlyBaseID:	FBgn0032442	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	184/781 - (23%)
Similarity:	311/781 - (39%)	Gaps:	195/781 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFLRSNITKSEPEA 206
            |:..|:...||||:||:|:||.|......|:...:..:....|..|...::.||: |.||.|.|.
  Fly    44 LLSTMNRTIDPCENFYEFSCGGWKKADLVPEQARNTSFLNAIQHKIDEQIQGFLQ-NATKRELED 107

  Fly   207 VG---------KAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLG-------SGS 255
            :|         |||..|.:|::.|                         .||:||       .|.
  Fly   108 LGVNGTTSAEIKAKQFYASCVEMK-------------------------ANLSLGYQYFMEHDGD 147

  Fly   256 KYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDSH 320
            :  .:..|..|:|:.          ::.:..:|::|        .:||
  Fly   148 R--LKERNATYDWMY----------INFMSKYDIYP--------LLAL----------------- 175

  Fly   321 KMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQ 385
                |:|..|                          :|......|....||:..:......|:.:
  Fly   176 ----KVHYST--------------------------SSRKFDILLTLPSKVLAGFSEEQLKNMTR 210

  Fly   386 EEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPI 450
            |   .|:..       .|.||.:|.|...|:|:..:|      .::|...:|:|:: :..|...:
  Fly   211 E---FGLDS-------SAEKVKQFVENFNNLTQFERN------LVSLAKSRNETEQ-LNFKEFLV 258

  Fly   451 --------WVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFL 507
                    |.|:.||...|::        ::...:.:|.|  .:.::|.:|:.|....::.|:
  Fly   259 KHKHDRLNWTRFFELAFNGSQ--------ESHWPVLNQLD--NINDLVFFLEQTNLETLKGYI-- 311

  Fly   508 STIEELVLH------------TSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYV 560
             .:.|||..            ..|..|.|...|...|                   ||...:..|
  Fly   312 -KMRELVKFYGLWKTQTKTGGVQSECRSLSETYFNYA-------------------LLPWFIGKV 356

  Fly   561 LADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASV 625
                 |.||:...:..:..||:.:|..|:...:|:|..|:.:...|.|.|...:|:...|::..|
  Fly   357 -----FDKERRADILSVAKDIKDTFYDLLDHHTWLDEDTRSQAKTKLASMDILVGYTDDLQHREV 416

  Fly   626 LNAYYEGAEVNASTH-LENLMDFVHWQMMDKLNEMDKP-EPIGWATSPSNVNAFHTFQSNAITVP 688
            ::..|  :::|.:.: .|||......:...:|..:||. .|:...|  ..|||::....|...:.
  Fly   417 IDGVY--SDINMTGNWFENLCILEGSRARIRLRSVDKALIPLLMPT--RTVNAYYADFLNLAFIT 477

  Fly   689 IAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTEC 752
            |.:.|:|||.:.. :.|.|..:|.|:|||:.||||....:::..|....|||:.::..:..|..|
  Fly   478 IGMAQWPFYHIDFPDVLKYAGVGNIIGHEMAHGFDSYCYQYNYDGKKTNWWSSASLRNFKERYRC 542

  Fly   753 FVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQL 817
            ...||:::.|..:.  .:|.||.|:|||||.|.|.|:||::....:.......|.|: :::::||
  Fly   543 LESQYNKFILMGVQ--TNGSLTSGDNIADNVGTRMAYYAFKRKTGDKAWLEKPLRGV-NFNNKQL 604

  Fly   818 FFISFGNLWCETYTPAAS-RYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRI 881
            ||:.|...||........ |...||.|...:.|::|.|||..||:..|.|..||.||| ..||.:
  Fly   605 FFVKFAQTWCNGKDNGDKLRRLKTDVHAYDEFRVQGTLSNMPEFSEAFNCKLGTEMNP-LKKCVV 668

  Fly   882 W 882
            |
  Fly   669 W 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	182/775 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	180/768 (23%)
Nepl7	NP_001285879.1	PepO	43..669	CDD:226118	183/779 (23%)
Nepl7	NP_001285879.1	M13	52..666	CDD:189000	179/768 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920