Protein Alignment Nep5 and Nepl4

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_609019.1
• Gene: Nepl4 / 33889
• FlyBaseID: FBgn0031805
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 804
• Identity: 168/804 - (20%)
• Similarity: 274/804 - (34%)
• Gaps: 262/804 - (32%)

  Fly   141 SLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVRE-FLRSNITKSEP 204
            :|:..:|.:.:||||||.:.||:|..:|   .|.|:.....|.|  |.|...: ||:.....|.|
  Fly    49 TLMSYVDSEKNPCEDFYAYACGKWRAKH---GSHTTATMISESQ--INRQYEDLFLQLLRNPSAP 108

  Fly   205 E----AVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLT-----LGSGSKYATE 260
            |    ...|....|::|:   .|:|.||...|..|.|    .|.::||.|     |.:..:|...
  Fly   109 EYGYPMFAKVLAHYQSCI---ALEKPDLRRYIELLDR----DLLASLNSTHWMHLLAALGRYGYH 166

  Fly   261 A--ANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDS---- 319
            .  ..|:..|..:    ..|:         :|..|.||.:| ::|.....|:   .:.|.|
  Fly   167 GHYVQVEVRWYNA----THHM---------IFLLPHNRHLN-LSLTQDIYDA---LSQDGSSWPP 214

  Fly   320 -HKM---LRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVD 380
             |::   .|.:.:..:.:......||                 |.....|..:|..:
  Fly   215 LHQLQEQFRSLEQNLVRLAKPHSADD-----------------TFRNYSLDQIRTEV-------- 254

  Fly   381 PNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAP 445
            |.::.:||                                              |:.|..:::
  Fly   255 PGLHWDEA----------------------------------------------LRTQLGRSV-- 271

  Fly   446 KTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTI 510
                               .||        .:....|:..::.:|||              |:|:
  Fly   272 -------------------PGN--------HVFQVDDLDAIEGLVEY--------------LNTV 295

  Fly   511 EELVLHTSSSMR----LLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKL 571
            :.|:|:..|..|    ||...:..:|....|...|...|...:...:.:.::||
  Fly   296 DTLLLNRYSLARFLSHLLELPHNPLATWESGQRSRGRNCIRHMRRSVYLPMNYV----------- 349

  Fly   572 PKVERMLSDIRRSFDRLVKSTSWMDAATKR----------------KTIQ-KSAEMKSFIG-FPP 618
              .||.....||..|.||..:.:....::.                |::| |..:|:..:| .||
  Fly   350 --YERSFYSRRRHADELVIHSVFQQLQSQLELRVQHNAFNLSQDLVKSLQAKVHQMRINVGNLPP 412

  Fly   619 -------W--LRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPEPIGWAT----- 669
                   |  .|..||...:||       .||.:|: :.:..:.|..:..|:.|...|.:
  Fly   413 NVTEQFYWDSDRRWSVGRDFYE-------NHLNSLL-YYYTLVADLESSSDQEERDIWYSFNMHT 469

  Fly   670 --SPSNVNAFHTFQ--SNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFD 729
              .|.|::|...|.  .|.|.||.:.::.||:|... .||.||.:...||||:.|.||.....:|
  Fly   470 PEFPDNIDATPYFYCLGNIIFVPYSYVKRPFFDANFWPALLYGDLANTLGHEIMHAFDTDLVDYD 534

  Fly   730 RAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRL 794
            ..||:      |...:.:..    ||.|:    ..:.......:.|.|..:|..|.|.|...|
  Fly   535 AQGNL------RNFSDQLGE----VELYN----GAVGCLNSSAVMLNERTSDVSGSRLAMQTY-- 583

  Fly   795 YVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEE 859
                 |.:     .|....:.:|:|:.|.:.:|   .....:|     |..|..||...|....:
  Fly   584 -----GGD-----WLTRSGNGRLYFLQFAHFFC---GDEGDQY-----HDSGSQRLNYALGQVPQ 630

  Fly   860 FARTFKCARGTPM-NPDQPKCRIW 882
            ||..|:|..|:.| :.||  |..|
  Fly   631 FAEVFRCHVGSGMTSADQ--CPFW 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	164/790 (21%)
Nepl4	NP_609019.1	GluZincin	59..649	CDD:472708	164/789 (21%)