DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Nep3

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001245775.1	Gene:	Nep3 / 33005	FlyBaseID:	FBgn0031081	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	775	Identity:	206/775 - (26%)
Similarity:	362/775 - (46%)	Gaps:	113/775 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 CRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREF 194
            |.:|.|:..::.::.::|...|||:|||.::|.:|...:|.|:..::...|.:.:.....::|..
  Fly   103 CLNKHCIFASSEILKSIDVTVDPCDDFYGYSCNQWIKNNPIPEGKSTWGTFGKLEQMNQLIIRNV 167

  Fly   195 LRSNITKSEPEAVGKAKTMYRACMDT-KLLDKRDLEPLINYLLRF-GLPVLPSALNL---TLGSG 254
            |.......:.:|..|||..|.:|:|. :.::|...:|:.:.||:. |..|..|..|:   |:|
  Fly   168 LEKPAKSFKSDAERKAKVYYESCLDADEHMEKLGAKPMNDLLLQIGGWNVTKSGYNVANWTMG-- 230

  Fly   255 SKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFN--RTINRIALGTPETDSAFPFNND 317
              :..:..:.|||:             :.:.|:.:..|..|  |.:.:|..|.....:|..:||.
  Fly   231 --HTLKILHNKYNF-------------NCLFGWAIGEDDKNSSRHVIQIDQGGLTLPTADYYNNK 280

  Fly   318 DSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPN 382
            ..:      |||.                              :..|:.|:.||.  .||    .
  Fly   281 TDN------HRKV------------------------------LNEYIEYMTKVC--VLL----G 303

  Fly   383 VNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKT 447
            .|:.:|...:..::           .|:::..|:|.|            |:|.:|:     ....
  Fly   304 ANESDARAQMIGVI-----------NFEKKLANITIP------------LEDRRNE-----EAMY 340

  Fly   448 LPIWVRYMELI---LKGTRHAGNIQMTQNLTIITSQADITY-------LQNIVEYLDDTPASHI- 501
            .|:.:|.:..:   |..|.|..|........:...:..:.|       |.:|:..::.|....|
  Fly   341 HPMQLRQLSKLAPFLNWTDHFDNAMQMVGRRVTDDEVVVVYAPDFLKNLSDIILKMEQTEEGKIT 405

  Fly   502 -ESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADAD 565
             .:||....:..|....|...|..:....:..:|::|......||.:..|:::|.||..:.....
  Fly   406 LNNYLVWQAVRTLTSCLSKPFRDAYKGVRKALMGSDGGEEIWRYCVSDTNNVVGFAVGAIFVRQA 470

  Fly   566 FTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYY 630
            |..|..|..|:|:::||.:|...:::.:|:|..|:.|.|:|:.::...||||.::.:...|:..|
  Fly   471 FHGESKPAAEQMIAEIREAFKMNLQNLTWVDKQTREKAIEKANQISDMIGFPDYILDPVELDKKY 535

  Fly   631 EGAEVNASTHLENLMDFVHWQMMDKLNEMDKP-EPIGWATSPSNVNAFHTFQSNAITVPIAILQY 694
            ....:..:.:.||.:....:.:...|..:|:| ....|..:|..|||::|...|.|..|..|||.
  Fly   536 AELNITPNAYFENNIQVAIYNLKSNLKRLDQPVNKTNWGMTPQTVNAYYTPTKNQIVFPAGILQT 600

  Fly   695 PFYDL-GLEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYS 758
            ||:|: ..::||:|::|.::||||||.|||.||.:|:.||:..||.:::|:.:..::||...|||
  Fly   601 PFFDINNPKSLNFGAMGVVMGHELTHAFDDQGREYDKFGNINRWWDSKSIERFNEKSECIARQYS 665

  Fly   759 RYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFG 823
            .|.:.  ...::|:.|||||||||||::.|::||:....:...:..||||| :.:|.||||:||.
  Fly   666 GYKMN--GRTLNGKQTLGENIADNGGLKAAYHAYQRTKSDRDVDILKLPGL-NLTHSQLFFVSFA 727

  Fly   824 NLWCETYTPAASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .:||.:.|...:...: .|.|.|.|.|:.|.|||.:|||..|:|..|..|||.: ||.:|
  Fly   728 QVWCSSTTDETNLLQMEKDPHSPSQFRVIGTLSNMKEFAEVFQCKPGKRMNPTE-KCEVW 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	202/757 (27%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	200/750 (27%)
Nep3	NP_001245775.1	M13	123..784	CDD:189000	200/751 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920