DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Mmel1

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	828	Identity:	236/828 - (28%)
Similarity:	396/828 - (47%)	Gaps:	130/828 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GLLALVIILLIAIIVISLGL--------------------------------KKSSSICRSKECL 136
            |||.|:.:||:..|| :||:                                .:.|.||.:..|:
  Rat    28 GLLVLLTLLLMGAIV-TLGVFYSIGKQLPLLNSLLHVSRHERTVVKRVLRDSSQKSDICTTPSCV 91

  Fly   137 RTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFLRSNITK 201
            ..||.::..||:...||::|||:.||.|...|..|::.:....|...:..:..:::..|..:..:
  Rat    92 IAAARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSSVQ 156

  Fly   202 SEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYL-LRFGLPVLPSALNLTLGSGSKYATEAANVK 265
            ..| ||.||||:||:||:..:::|||.|||:|.| :..|.||.....|.|:|.           |
  Rat   157 HRP-AVEKAKTLYRSCMNQSVIEKRDSEPLLNVLDMIGGWPVAMDKWNETMGP-----------K 209

  Fly   266 YNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRT-----INRIALGTPETDSAFPFNNDDSHKMLRK 325
            :...:.:..:.......::|...::.|..|.:     |::..||.|..:..|   .:|||::
  Rat   210 WELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYF---KEDSHRV--- 268

  Fly   326 IHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATL 390
                                ||               |||.::..|..  :|..|.|:.
  Rat   269 --------------------RE---------------AYLQFMTSVAT--MLRRDLNLP------ 290

  Fly   391 GITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTD-KNIAPKTLPIW 451
            |.|:||::  .:|:.:| .:....|.|.|.:...| ..:|  :.|::||.:.. |...      |
  Rat   291 GETDLVQE--EMAQVLH-LETHLANATVPQEKRHDVTALYHRMGLEELQERFGLKGFN------W 346

  Fly   452 VRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLH 516
            ..:::.:|...:    :::..|..::.  ..|.||:|:.|.:|..||..:::||....:.:.:..
  Rat   347 TLFIQNVLSSVQ----VELLPNEEVVV--YGIPYLENLEEIIDVFPAQTLQNYLVWRLVLDRIGS 405

  Fly   517 TSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDI 581
            .|...:....:|.:...||.....|...|.:.|||.:..||..:.....|:|:....|..::..|
  Rat   406 LSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSIVSELIEKI 470

  Fly   582 RRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWL--RNASVLNAYYEGAEVNASTHLENL 644
            |..|...:...:|||..:|:|..:|:..::..||:|.::  .|...|:..|.....:...:.||.
  Rat   471 RSVFVDNLDELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENG 535

  Fly   645 MDFVHWQMMDKLNEM-DKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYG 707
            :..:.......|.:: :|.:...|....:.||||::...|.|..|..|||.||:.... :|||:|
  Rat   536 LQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGILQPPFFSKDQPQALNFG 600

  Fly   708 SIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY--HLADIDEYID 770
            .||.::|||:||||||:||.||:.|||::||||.:...:..:::|.:.|||.:  .||| ::.::
  Rat   601 GIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIYQYSNFSWELAD-NQNVN 664

  Fly   771 GELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPA-A 834
            |..|||||||||||:|:|:.||..::.|.||:: :|||| :.::.|||||::..:||.:|.|. |
  Rat   665 GFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQ-RLPGL-NLTYAQLFFINYAQVWCGSYRPEFA 727

  Fly   835 SRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .:...||.|.|.:.|:.|.|.|...|:..|.|.||:||:| ..:||||
  Rat   728 IQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHP-MNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	218/752 (29%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	214/745 (29%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	214/745 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920