Protein Alignment Nep5 and ECE1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 830
• Identity: 240/830 - (28%)
• Similarity: 396/830 - (47%)
• Gaps: 131/830 - (15%)

  Fly    83 PNLIGIQSKF------RRSYYHKVVLGGLLALVIILLIAIIV---ISLGLK---KSSSICRSKEC 135
            ||  |:|..|      :|.:..:..:...|.::::||.|.:|   .:||::   :|.|:|.|:.|
Human    50 PN--GLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEAC 112

  Fly   136 LRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFLRSNIT 200
            :...:|::.:||...|||.||:.:.||.|...:|.||..:....|.....|...:::..| .|.|
Human   113 VSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLL-ENST 176

  Fly   201 KSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVK 265
            .|..||..||:..|||||:...:::...:||:..:.|.|      ..|:|    ..:|      |
Human   177 ASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLG------GWNIT----GPWA------K 225

  Fly   266 YNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRI-----ALGTPETDSAFPFNNDDSHKMLRK 325
            .|:..::..:..|..........|..|..|...|.|     .||.|..|  :..|..::.|:|
Human   226 DNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRD--YYLNKTENEKVL-- 286

  Fly   326 IHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATL 390
                                                |.||:|:.: :.|.|     ....|||
Human   287 ------------------------------------TGYLNYMVQ-LGKLL-----GGGDEEA-- 307

  Fly   391 GITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTDKNIAPKTLPIWV 452
             |...::|       :.:|:....|:|.|.:...| :::|  :|..:||     .:||..  .|:
Human   308 -IRPQMQQ-------ILDFETALANITIPQEKRRDEELIYHKVTAAELQ-----TLAPAI--NWL 357

  Fly   453 RYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHT 517
            .::..|..      .:::.::..|:.  .|..||:.|...::.|....:.:|:    |..||..|
Human   358 PFLNTIFY------PVEINESEPIVV--YDKEYLEQISTLINTTDRCLLNNYM----IWNLVRKT 410

  Fly   518 SSSM----RLLHSEYMRVAIGTEGS-TPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERM 577
            ||.:    :....::|.|..||:.: .||..:|.:...:.||.|:..:...|.|.::.......:
Human   411 SSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEI 475

  Fly   578 LSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLE 642
            :.:|:::|:..:.:..|||..|::...:|:..:.:.||:|.::.:...|:..:.........:.|
Human   476 ILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFE 540

  Fly   643 NLMDFVH--WQM-MDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EA 703
            |.|.|.:  |:: .|:|.:  .|....|:.:|..|||:::...|.|..|..|||.|||.... :|
Human   541 NAMRFFNFSWRVTADQLRK--APNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKA 603

  Fly   704 LNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEY 768
            ||:|.||.::||||||.|||.||.:|:.||:..||.|.:::.:..:|||.|||||.|.:.  .|.
Human   604 LNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVN--GEP 666

  Fly   769 IDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPA 833
            ::|..|||||||||||::.|:.||:.:||:.|.|.| ||.| ..::.||||:.|..:||...||.
Human   667 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHS-LPTL-GLTNNQLFFLGFAQVWCSVRTPE 729

  Fly   834 ASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            :|...| ||.|.|.:.|:.|.||||:||:..|:|..|:||||.. ||.:|
Human   730 SSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPH-KCEVW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	217/746 (29%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	217/747 (29%)