Protein Alignment Nep5 and nep-20

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_001317749.1
• Gene: nep-20 / 188176
• WormBaseID: WBGene00020293
• Length: 834
• Species: Caenorhabditis elegans
• Alignment Length: 926
• Identity: 188/926 - (20%)
• Similarity: 331/926 - (35%)
• Gaps: 244/926 - (26%)

  Fly    25 QQQPLPLQRLQTP-GNLSLLSAPIRANGSGNGNATANGHGQNSATESAN-----GKQLPYEPISP 83
            |:.| |.|::... ||..:...|......||....||.....:....||     ...:|..|::|
 Worm    79 QENP-PNQKVPANLGNQGVSVIPANPGNQGNPANPANPVIPANPVIPANPVIPANPVIPANPVNP 142

  Fly    84 -NLI-----GIQSKFRRSYYHKV-------------------VLGGLLALVIILLIAIIVISLGL 123
             |.:     .::.|.:|....|.                   ::..:..:::|:|..:::. :|.
 Worm   143 ANPVIPAKQNMEKKNKRKEKEKERKKAEKFSADEKTANIKDRIINCVYPVILIILFWLLLF-IGA 206

  Fly   124 KKSS--SICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAH 186
            ::..  |:|.|.:|:..|..|....|.....|.:||:.|||:: ..|...|        :.|.|.
 Worm   207 RQDEKPSLCESPQCITLAFELSAYQDTSVSKCHNFYKATCGKY-KHHQALD--------KHRDAK 262

  Fly   187 ----IMRVVREFLRSN----ITKSEPEAVGKAKTMYRAC----MDTKLLD-KRDLEPLINYLLRF 238
                :.|:||||||.|    .:|.||    ..:.|:..|    .:...|| .:|:|.:..:
 Worm   263 KKEVVKRIVREFLRRNESSITSKFEP----AIRLMFGKCNKFSQNKTYLDIFKDIEKIGPW---- 319

  Fly   239 GLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIAL 303
              |||                     |.:|:..:.::..:|...:.:||..| ..|.....::|.
 Worm   320 --PVL---------------------KSDWVDVMFNLNDYLLSLVELGFTDF-GLFKLEFRQLAF 360

  Fly   304 GTPETDSAFPFNNDDSHK---MLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYL 365
            |      .||.......|   .|.||..: |...|....|
 Worm   361 G------QFPVIAPSEQKQGNQLEKIILE-ILEANGVQAD------------------------- 393

  Fly   366 HYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYI 430
               |:.:.|||                           |:..|||.:..:|:
 Worm   394 ---RQKLSKYL---------------------------REYSEFKSQLRHMS------------- 415

  Fly   431 TLQDLQNQTDKNIAPKTLPIWVRYMELILK---GTRHAGNIQMTQNLTIITSQADITYLQNIVEY 492
                |:..:.|.|......:.|....|:.|   .:..:|.::..|:..:||:.:.. :.:|:...
 Worm   416 ----LEGTSVKYIRYNASTLSVNISALVQKMAPMSTSSGLVRRIQSGILITNSSSF-FGKNLDAI 475

  Fly   493 LDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAV 557
            :..|....:.:||....|:.:....:|..:  |||:..:.:...||.
 Worm   476 IQQTHKRTLANYLIFHFIDAVTFDLTSGAK--HSEHTLIDLLPRGSL------------------ 520

  Fly   558 SYVLADADFTKEKLPKV-ERMLSDIRRSFDRLVKSTSWMDAA-------TKRKTIQKSAEMKSFI 614
             .||:. ||..|:...| ..|..|:::....::...|.:|..       .:||.|:|..::....
 Worm   521 -QVLSQ-DFVDEEDQGVMVEMAKDLKKHVVEMISEGSSLDKGHLVFEEKERRKLIRKVQDILVVT 583

  Fly   615 GFPPWLRNASVLNAYYEGAEVNASTHL----ENLMDFVHWQMMDKL-NEMDKPEPIGWATSPSNV 674
            .:|     ..:||..:|...:..|..|    :.|..|...|:::.| .::|..:...|.
 Worm   584 KYP-----LEILNQNFEKLNLTYSDSLHKIIQKLRRFRSEQLIEYLGGDLDPTDKGMWG------ 637

  Fly   675 NAFHTFQSNAITVPIAILQYPFYDLGLEALNYGSI---GTILGHELTHGFDDSGRRFDRAGNMVE 736
            :|.:...:|.:.:...|:..|::|....  ||.:|   |.|:..||....|....|.|..|:...
 Worm   638 SAHYEQATNDLIIIAPIIDGPYFDTSYP--NYVNIFFMGFIISRELGRSLDSVRIRKDEKGHTEN 700

  Fly   737 WWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEV-G 800
            |..:.::..:.|..:|:.::            |.|...|.|.:||:.|...:|.|.:.:.||: |
 Worm   701 WLKSESLKRFDNNVKCWRKK------------ITGTRFLNEMLADHVGHEASFMALKKWEKEMNG 753

  Fly   801 RERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALT--DSHCPGQMRLRGVLSNSEEFART 863
            ....|:.|.|..:.||:||......:|.  .|..|...||  |:......|:.....|..:||:.
 Worm   754 TIVEKIRGYESMTMEQIFFHLQALYFCR--PPGGSTGELTAKDARQHYSTRVNEAFKNMPQFAKA 816

  Fly   864 FKCARGTPMNPDQPKC 879
            |.|:....|| .:.||
 Worm   817 FGCSSNQNMN-SKTKC 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	158/767 (21%)
nep-20	NP_001317749.1	PHA02030	<71..139	CDD:222843	14/60 (23%)
		GluZincin	238..832	CDD:472708	158/765 (21%)