DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and Phex

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_035207.1	Gene:	Phex / 18675	MGIID:	107489	Length:	749	Species:	Mus musculus

Alignment Length:	812	Identity:	226/812 - (27%)
Similarity:	389/812 - (47%)	Gaps:	120/812 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LGGLLALVIILLIAIIVISLGL---KKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGR 163
            :||.|.|..:|.:    :|.||   :.....|...||:..||:::..::...||||:|::|.|..
Mouse    27 IGGTLVLGTLLFL----VSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDG 87

  Fly   164 WANEHPRPDSVTS---NDWFRERQAHIMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDK 225
            |.:.:|.|:.:.|   ..|.|......::.:.|  :|...:.:.|||.|||.:|.:||:.|.::|
Mouse    88 WISNNPIPEDMPSYGVYPWLRHNVDLKLKALLE--KSVSRRRDTEAVQKAKILYSSCMNEKAIEK 150

  Fly   226 RDLEPLINYLLR---FGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGF 287
            .|.:||: ::||   |..|||.:    .:|....::..    |::.||::.:.:...:..:.|..
Mouse   151 ADAKPLL-HILRHSPFRWPVLEA----NIGPEGVWSER----KFSLLQTLATFRGQYSNSVFIRL 206

  Fly   288 DVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEE 352
            .|.||                |.|       |::.:.|:.:.|:.:...:|..|:..:.:|
Mouse   207 YVSPD----------------DKA-------SNEHILKLDQATLSLAVREDFLDNTTEAKS---- 244

  Fly   353 AAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFK------- 410
                           .|..:.|::               :...|..|...:|..|:.|
Mouse   245 ---------------YRDALYKFM---------------VDTAVLLGANSSRAEHDMKSVLRLEI 279

  Fly   411 EEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPI----WVRYMELILKGTR---HAGNI 468
            :.||.|. |.:|...:.:|         ...||:..:..|    |:.|::.:: .||   |..:|
Mouse   280 KIAEIMI-PHENRTSEAMY---------NKMNISELSAMIPQFDWLGYIKKVI-DTRLYPHLKDI 333

  Fly   469 QMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAI 533
            ..::|:.:...|    |.:::...|.......|.:||....:...:.:.|...:....|:.||..
Mouse   334 GPSENVVVRVPQ----YFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQ 394

  Fly   534 GTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSF-DRLVKSTSWMDA 597
            ||....|:...|.|.:.|.|...|..:..:..|.::|...:|.::..:|.:| |.|.|...||||
Mouse   395 GTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWMDA 459

  Fly   598 ATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKP 662
            .||||..:|:..:.:.:|:|.::.|.:.:|...:..:.:.|.:..|::....:........:.|.
Mouse   460 GTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKYLAQSDFFWLRKA 524

  Fly   663 EP-IGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGLE---ALNYGSIGTILGHELTHGFDD 723
            .| ..|.|:|:.||||::..:|.|..|...||.||: .|.|   :|:||:||.|:|||.|||||:
Mouse   525 VPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFF-WGTEYPRSLSYGAIGVIVGHEFTHGFDN 588

  Fly   724 SGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREA 788
            :||::|:.||:..|||..:.:::..:|:|.:.|||.|:.......:.|:.|||||||||||:|||
Mouse   589 NGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREA 653

  Fly   789 FYAYRLYV--KEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSHCPGQMRL 850
            |.|||.::  :..|.|...|||:. :::.||||:|:.::.|.:|.|.|:|..: ..:|.|.|.|:
Mouse   654 FRAYRKWINDRRQGVEEPLLPGIT-FTNNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRV 717

  Fly   851 RGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .|.:||.|||.:.|.|.|.:.||.....||:|
Mouse   718 NGAISNFEEFQKAFNCPRNSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	212/763 (28%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	210/756 (28%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	209/758 (28%)
Phex	NP_035207.1	M13	74..747	CDD:189000	210/757 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920