DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and nep-8

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001309548.1	Gene:	nep-8 / 184631	WormBaseID:	WBGene00017553	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	836	Identity:	162/836 - (19%)
Similarity:	300/836 - (35%)	Gaps:	241/836 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NLIGIQSKFRRSYYHKVVLGGLLALVIILLIAII-----------VISLGLK-KSSSICRSKECL 136
            |:..::.|..|.:    |...||.|::.|.:..:           ::|:|.. .|.::|.|.||:
Worm     2 NVKKVKEKLSRPW----VAVNLLLLIVFLAMVTVHIKVEPVNLDELLSIGNDVDSKNLCDSPECI 62

  Fly   137 RTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMR-VVREFLRSNIT 200
            ..:..|:...|...|||.||:|.:|||:..:     ||:.:.  .:::.||:| .:||||. .|.
Worm    63 TLSHELLNYQDPSVDPCVDFFQHSCGRFHEQ-----SVSESR--LQKKKHILRKQIREFLH-KIQ 119

  Fly   201 KSEPEAVGKAKTMYRACMDTK----------------------------LLDKR------DLEPL 231
            .|..::....|.::..|..:|                            ||||.      ||..:
Worm   120 NSTSKSENLMKLVFDKCEASKKTSNDNYKISRDAIHDVFNDIKKIGAWPLLDKNWDGSKFDLNEM 184

  Fly   232 INYLLRFGLPVLPSALNLTLGS-GSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFN 295
            ::.|::.|      |.||.|.. ..:..||...|:.  ..::.||..:.||..:|
Worm   185 LSNLVKLG------ATNLGLFQLDFRILTEGKFVRI--APTLGSIVHNSTMISMI---------- 231

  Fly   296 RTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEA-----AK 355
                                             ..|...|....|..|..:|.||..:     ||
Worm   232 ---------------------------------SEILEANGVQPDSEEISKEFEEYSSLQMKLAK 263

  Fly   356 QTSTG-MTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVAR---KVHEFKEEAENM 416
            ..|:| ::..|..||.:....|               |||::... ||::   |:.....|....
Worm   264 YQSSGKLSISLPGVRSINFSSL---------------ITEMIHPS-RVSKIFGKIRVVTSEHPLF 312

  Fly   417 TKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQA 481
            .|.::..:.|.:      :::.::|.:|...:..:::....|:||.|. ||.:
Worm   313 FKSNETESLDTI------IESTSNKTLANFLIFNYIQSSYNIMKGARR-GNCE------------ 358

  Fly   482 DITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCA 546
                        ||                            :..|:.|.::        .::..
Worm   359 ------------DD----------------------------VRREFPRASL--------RVFMR 375

  Fly   547 NGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMK 611
            |.|:                 |.....|:::..:::::...:::.|..:....|...::|...:|
Worm   376 NFVD-----------------KGNRDGVKKLTEELKKNTLEMIQDTENLAPPVKESMLKKVEAIK 423

  Fly   612 SFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPE---------PIGW 667
            ..||:|........|:..:|..:::::..        ::::..|||.:...:         ||..
Worm   424 VTIGYPDHFDPPGTLDKEFENFDLDSTDS--------YYRIFQKLNRLRSEQQMEFIAGETPISP 480

  Fly   668 ATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRA 731
            ......|||.:....||:||....|..||:|:.. :.:|....|.::.||:.|..|.:|..:|..
Worm   481 IKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFFSGFLIAHEIGHSVDANGLGYDEN 545

  Fly   732 GNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYV 796
            |..::......:.||..:.:|.|:||..|......:.::|..::.|.|||..|..   ..:|.|.
Worm   546 GKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEIIADWVGHE---VTWRAYK 607

  Fly   797 KEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRLRG 852
            |....:...|.||:..:.:||:|.....|:|......:....|.|.:.....|:.|
Worm   608 KMDTSKMLSLIGLKDINMDQLYFRVQSLLFCRERDTISLEETLKDVYPTDNFRVNG 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	146/762 (19%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	145/757 (19%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	145/758 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920