Protein Alignment Nep5 and nep-21

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 941
• Identity: 224/941 - (23%)
• Similarity: 390/941 - (41%)
• Gaps: 244/941 - (25%)

  Fly    70 SANGKQLPY------------EPI-------------SPNL-----------IGIQSKFRRSYYH 98
            |:||.|.|:            .||             :|.|           :.:.||.|::
 Worm    40 SSNGIQQPHIYACSDENSYYASPIFLTRTIDEPPKKPAPTLSRQSTCRPTSQLYLPSKKRKT--- 101

  Fly    99 KVVLGGL----------LALVIILLIAIIVI-------------------------SLGLKKSSS 128
            :..||.|          |.|:|..|::::.:                         |:.:.:|:.
 Worm   102 RSCLGRLTTLETLLLVFLGLLITALLSVLFLWLWVLDGYKTFTDGRPIYPLPFENSSVAVDRSAK 166

  Fly   129 -----ICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIM 188
                 :|.|:||:|.|..|...::.:.:||||||:|.||.:......|.:........:.|:.:.
 Worm   167 NHNDVVCTSRECVRLAGFLAENLNSKINPCEDFYEFACGNYGLNKNLPANKPLRHTISDVQSRLN 231

  Fly   189 RVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRF-GLPVLPSALNLTLG 252
            :.|:..|:|.|:.:|......||..|:.|:|.:.|:...:|.:.:...|. |.|.|
 Worm   232 KQVKSMLQSPISANEKPWDKVAKGYYQKCLDEEELESTGVEAMRDIAKRIGGWPTL--------- 287

  Fly   253 SGSKYATEAANVKYNWLQSIVSIKQHLTMDL------IIGFDVFPDPFNRTINRIALGTPE--TD 309
            .|.|:    ....::|.:.|.     |.::|      |:...|..||.|.:.:.|.|..|:  ..
 Worm   288 EGDKW----QEWSHSWEEQIA-----LVLNLTGVNAVILEMAVTHDPSNSSRSVIELDQPKWGAG 343

  Fly   310 SAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEK 374
            |.:|:.:..:..|||..   |..|                     |.|:..:.|
 Worm   344 SRYPYLSGANDPMLRNY---TTLM---------------------KMTAVALGA----------- 373

  Fly   375 YLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQT 439
                 ||.:.::|               ..:..||:.:..|.:      |||:|         :.
 Worm   374 -----DPAIAEKE---------------MNEAMEFELKLVNFS------ADDMV---------RR 403

  Fly   440 DKNIAPKTLPIW-----------VRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYL 493
            |.........:|           .:|::.:.|..     :.::.|.|:|..:.|  |...|...|
 Worm   404 DPERGNNRFELWQLKSVFPFINFEKYLKTVFKEL-----VALSPNHTVIVREID--YFVGIQHVL 461

  Fly   494 DDTPASHIESYLFLSTIEELVLHTSSSMRLLHS----------------------EYMRVAIGTE 536
            ..||...:.:|:              |.||:..                      ::.....|..
 Worm   462 QSTPKRVLANYI--------------SWRLVQGGPTGDYFSFSPFLPPSAREPFYQFKANQTGMF 512

  Fly   537 GSTPRSLY--CANGVNSLLGMAVSYVLADADFTKEK-LPKVERMLSDIRRSFDRLVKSTSWMDAA 598
            .|.|...:  |......::.|.|..:..:..|.||: :.|:..:.|.::..|.:.:....|||..
 Worm   513 NSPPPDRWEDCVTLSVIMMDMPVGRLFVENFFEKERAMKKMTELTSYLKNEFIKQLHVLDWMDEI 577

  Fly   599 TKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHW-QMMDKLNEMDKP 662
            |:|:.|.|:..::...|||..|.|.:.:...: |..:....:|.:|...|.. :..::|..:|:|
 Worm   578 TRRRAISKANMIEYKSGFPMVLFNDTWMEKNW-GMIIKPREYLLHLTIRVKLVRFTEELLRLDQP 641

  Fly   663 -EPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSG 725
             :...|..||:.|:|::...:|.:..|..|:|:||..||: ..:.||.:|.::|||::|.|||.|
 Worm   642 LDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQG 706

  Fly   726 RRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFY 790
            .::|..||:.:||...|.::::.:|.|||.||...|:.:.|.:::|:|:||||||||||::.||.
 Worm   707 GQYDEMGNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFN 771

  Fly   791 AYRLYVKE-VGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRY---ALTDSHCPGQMRLR 851
            ||:.:... .|.....|||.::::.:|:||:::.|.||....|  ..|   .|||.|.|.:.|..
 Worm   772 AYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRP--KHYIQIILTDVHAPSKYRAM 834

  Fly   852 GVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            ..|.|..|||:.|:|..|:||||:: ||::|
 Worm   835 IPLQNRPEFAKAFQCPIGSPMNPER-KCQVW 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	194/780 (25%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	194/781 (25%)