DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and nep-1

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	781	Identity:	220/781 - (28%)
Similarity:	360/781 - (46%)	Gaps:	106/781 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 KKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIM 188
            ||:.::..|:.....:..|..:::...|||:||:::.|..|.:.||.||.:||...|...:..::
Worm    58 KKTYTVGDSEGYQEASRLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVL 122

  Fly   189 RVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGS 253
            ..:|:....|.:....:::...|.:|..||||:..:......|:..:..:|
Worm   123 AEMRKLYEDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTYG-------------- 173

  Fly   254 GSKYATEAANVKYNWLQSIVSIKQHL-----TMDLIIGFDVFPDPFNRTINRIALGTPETDSAFP 313
               |.....|.|  |.:|...:.:.|     :.|:.:.||..|...:|.::|
Worm   174 ---YWPMVHNEK--WRESTFDLTKLLSNTIQSRDVSVFFDFGPAEDSRNVSR------------- 220

  Fly   314 FNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLY 378
                          |...|.|.|.....|..|...:|::..||    |.||..|....:..|...
Worm   221 --------------RLLSFDQGSLGLGYSTRDYYLDEKKYEKQ----MKAYRKYTIGKVRYYTED 267

  Fly   379 VDPNVNQEEATLGITELV---KQGVRVARKVHEFKEEAENMTK-PSKNPADDI-VYITLQDLQNQ 438
            ....||:.:....:.|::   |:..::.  |.|  |:..|.|| .:....||: .|:::.|.
Worm   268 AGMAVNESKIESDVDEIIAFEKEWAQIL--VAE--EDRRNYTKLYNVRRFDDLKEYMSIIDW--- 325

  Fly   439 TDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIES 503
              |.:...|.|..|           |:   .:..|.:||.|  |:.|||.:...|.:|....:.:
Worm   326 --KKLTLSTTPFLV-----------HS---YLKTNPSIIIS--DVEYLQKMNTLLQNTDPRIVTN 372

  Fly   504 YLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTK 568
            |:.|................|..|:.....|.:...||...|.:.....|..|...:.....|..
Worm   373 YILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSMYVRKYFDA 437

  Fly   569 EKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGA 633
            ........|::|::.:|..::.:..||||.||:..::|:.:|...||:|.::.|...|:.:|:|.
Worm   438 NAKNTTLDMITDLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILNDEKLDDWYKGL 502

  Fly   634 E----------VNASTHLENLMDFVHWQMMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVP 688
            |          |..|....|  :|.:.::::.:|..:      :.:|.:.||||::...|||..|
Worm   503 EGAPEDSFSQLVEKSIQWRN--NFYYRRLLEPVNRFE------FISSAAVVNAFYSPTRNAIAFP 559

  Fly   689 IAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTEC 752
            ..|||.||:|... :|||||.||.::|||:||||||:||:||..||:.:||.|.|..::..||:|
Worm   560 AGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQC 624

  Fly   753 FVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQL 817
            .:|||:...|...|..|:|:||.|||||||||:::||.||:.|:::.|.:.::||..|..::|||
Worm   625 IIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESLTNEQL 689

  Fly   818 FFISFGNLWCETYTP-AASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRI 881
            ||:.:..:||...|| ..:...|||.|.|...|:..||:|..|||..|||..|:||||.: :|.:
Worm   690 FFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAFKCPAGSPMNPTK-RCVV 753

  Fly   882 W 882
            |
Worm   754 W 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	215/757 (28%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	214/750 (29%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	215/757 (28%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	214/749 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920