DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and nep-5

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001364754.1	Gene:	nep-5 / 173933	WormBaseID:	WBGene00017393	Length:	694	Species:	Caenorhabditis elegans

Alignment Length:	842	Identity:	177/842 - (21%)
Similarity:	294/842 - (34%)	Gaps:	272/842 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VLGGLLALVIILLIAIIVISLGLKKSSSI-----------------CRSKECLRTAASLIYAMDE 148
            ||..:..|||::|:...:.:|||...|:.                 |::|||::.:|.|:..||.
Worm    62 VLAVITTLVILVLLIFALGALGLHDISAFKWEPKPQKALRIMLDLPCQTKECVKYSAELLELMDS 126

  Fly   149 QTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFLRSNITKSEPE---AVGKA 210
            ..:|||:|:...|..:   :||     ..|:.|     :|:::      || :.:|:   ||...
Worm   127 SVNPCENFHHHVCNGF---NPR-----KKDFER-----LMKLI------NI-QEKPDHRKAVNVV 171

  Fly   211 KTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSI 275
            :.|...|...|..:...:..|.:.:|. ||| .|...|.........:|..::..|:: ..:..|
Worm   172 RRMLSKCAMGKTEEIHQVGRLSSIILP-GLP-FPLLNNSWTKPSDPISTSNSSTTYSY-PFLTKI 233

  Fly   276 KQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAF------PFNNDDSHKMLRKIHRKTIFMQ 334
            ..|:         :..:|.:.....|   .|.:||.|      ||:...::...|.::  .|..:
Worm   234 LAHI---------ILHNPDDAGFVGI---KPSSDSEFSLFVVKPFSPVLTNFKFRNMY--DILKR 284

  Fly   335 NSDDED-----DSEDDRESEEEEAAK-QTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGIT 393
            |:.:..     |.|.||:.:..:..| ||.             :||.....||.|
Worm   285 NAPESSTNGMIDLEFDRQRQLNDVIKLQTK-------------LEKIEFKADPEV---------- 326

  Fly   394 ELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQNQTDKNIAPKTLPI--WVRYME 456
                                                :.|.::|.|         :||  |.|.::
Worm   327 ------------------------------------VNLTEIQRQ---------MPIIDWKRLID 346

  Fly   457 -LILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFL------------S 508
             .|..|..|         |.......:.:|.:.|...:..||:..|.::|||            |
Worm   347 SWIPNGYAH---------LKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLRFSFKFLRTEVAS 402

  Fly   509 TIEELVLHTSSSM---RLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEK 570
            .:|:..||..|:.   ::       |..|:|  .|.:|...||
Worm   403 DLEDTCLHQLSTTIPGKI-------VLYGSE--EPEALNLLNG---------------------- 436

  Fly   571 LPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEV 635
                  ||..|:....|.:.:..|||:....:..:|..:.|:..||     ....|.....|...
Worm   437 ------MLHTIKDQLKRSLATLKWMDSRGIEEAQKKFNKTKTVFGF-----TGEDLIDELVGKIT 490

  Fly   636 NASTHLENLMDFVHWQMMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLG 700
            ..|.::..|.:.:.||..:....:.:..    .|...|...|::.:.|.||:..|:|.|||....
Worm   491 PESNYISTLQNVLLWQTRNMFKSVAENN----VTVFLNSEVFYSVEKNEITISRALLHYPFMSAN 551

  Fly   701 LEALNYGSIGTILGH---ELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHL 762
            |.  ||.:..||...   ::.|.||:.||.:|..||...||:..|...:....:||
Worm   552 LP--NYTNFATIASKILPQMIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCF--------- 605

  Fly   763 ADIDEYIDG--------ELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFF 819
                   ||        .:::|.|..|:  .:|.:              :.|||::..|.|.|||
Worm   606 -------DGMMQNVFGVSVSIGWNAYDS--TKEPY--------------ATLPGIQQSSDEALFF 647

  Fly   820 ISFGNLWCETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRI 881
            .|.....| |..|.               .:...|::..:|...|||..||.||| ..||::
Worm   648 YSMVKTMC-TSDPD---------------NVNEALASVPQFNSAFKCNNGTKMNP-PTKCKL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	161/780 (21%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	158/772 (20%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	158/773 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920