DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and nep-12

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	889	Identity:	234/889 - (26%)
Similarity:	389/889 - (43%)	Gaps:	151/889 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SAPIRANGSGNGNATANGHGQNSATESANGKQLPYEPISPNLIGIQSKFRRSYYHKVVLGGLLAL 108
            |..|..|..|..:.:::|..:.|...|::...|.:.|            .|:.....|...|..|
Worm    45 STTITTNSGGGRSNSSSGATEISDCSSSDVSHLEHFP------------DRNARLAAVFAALFIL 97

  Fly   109 VIILLIAIIVI------------------------SLGLKKS--------SSICRSKECLRTAAS 141
            .:::.|:.|.|                        :..:|.|        :|.|.:.||:|.|||
Worm    98 TLLISISFITIVAILSDGFSTLISGSELCSNTEGDAYEVKNSNHVNYGSDNSTCLTPECIRLAAS 162

  Fly   142 LIYAMDEQTDPCEDFYQFTCGRWAN-----EHPRPDSVTSNDWFRERQAHIMRVVREFLRSNITK 201
            .:..|:...:||||||:|.||::|.     ||.:..:|.| :..:|...|:..::.:..|.|.|:
Worm   163 YLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVTVLS-EMKKEMDRHLKDILEKTSRENTTR 226

  Fly   202 SEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRF-GLPVLPSALNLTLGSGSKYATEAANVK 265
            |    :..|:..:.:|||....|...::||::.:... |.|:|.:|             ...::.
Worm   227 S----MKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNA-------------RFDSID 274

  Fly   266 YNWLQSIVSIKQHLTMDLIIG-FDVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRK 329
            :.|    ..:..||.:..:.| |.||                 ..|:|    |||.|.:......
Worm   275 FQW----EVLAGHLALYGVDGIFRVF-----------------VHSSF----DDSDKNVLMFSPP 314

  Fly   330 TIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITE 394
            .:|:               |:::..::..:. ..||.|.|:.|...|..:  .|:.|:.| |:.|
Worm   315 KLFL---------------EKKKFYREVPSS-NVYLQYYRQYILSLLSLL--GVDMEDET-GVIE 360

  Fly   395 LVKQGVRVARKVHEFKEEAENMTK--PSKNPADDIVYITLQDLQNQTDK-NIAPKTLPIWVRYME 456
            .      ....:.:|:....|:|:  .|:|.:.....||..:.:.:.|| |        |..:.
Worm   361 Y------QVDDIIDFERRIANLTRIELSRNHSSINNMITFGEFKRKYDKIN--------WDAFF- 410

  Fly   457 LILKGTRHAGNIQMTQNL-----TIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLH 516
                      |.:|..||     :::.:..|:.|..|:...:...|.|.|.::|....:....::
Worm   411 ----------NEEMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDMY 465

  Fly   517 TSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDI 581
            ..:..|....::.:...|.....|....|...|...|.|.:|...|...|||:.....|.|:.|:
Worm   466 LPAKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDL 530

  Fly   582 RRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMD 646
            :::.::.:.:..|:|.:|:...:.|...|...||||..|.|.:.:...|.|..:.|:.:.:|.:.
Worm   531 KKAMEQTLLNADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYAGVRLTANQYFDNAIS 595

  Fly   647 FVHWQMMDKLNEMDK-PEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGLEAL-NYGSI 709
            .......|.|:::.: |..|.||:....|:|||.|..|.|..|..|||:|.:.....|. |||:|
Worm   596 LKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHYFTGNEIIFPAGILQFPMFVPDAPAFSNYGAI 660

  Fly   710 GTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELT 774
            |..:|||:|||:||.|.::|..||:..||...|:..:..:.:|||.||...........:||::|
Worm   661 GMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMT 725

  Fly   775 LGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL 839
            :|||||||||:|.||.||:|. .:..:|..:||||..:|..||||:::.|.|||...|:|..:.:
Worm   726 IGENIADNGGLRVAFQAYQLR-SDREKETRRLPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIM 789

  Fly   840 -TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
             ||.|..|..|:...|.|...|::.|.|..|:||||.: |||||
Worm   790 DTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFE-KCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	206/753 (27%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	203/746 (27%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	203/747 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920