DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and nep-13

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001342017.1	Gene:	nep-13 / 173672	WormBaseID:	WBGene00018196	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	188/832 - (22%)
Similarity:	320/832 - (38%)	Gaps:	209/832 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 IILLIAIIVISLGL-------------------KKSSSICRSKECLRTAASLIYAMDEQTDPCED 155
            ||:.:.||.|.:|.                   .|:..:|::.||:..:::|:...:...|||||
Worm    45 IIICLVIIAICMGAVIVFWRMDSAPQAICKTDHNKTRDVCKTAECITLSSTLLNWQNTNIDPCED 109

  Fly   156 FYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREF-LRSNITKSEPEAVGKAKTMYRACMD 219
            ||:::|||: .||...|.:.:|    |:...:|:::|:| |::..|.|..|  .....:|..|..
Worm   110 FYEYSCGRY-QEHTLNDGIRAN----EKDTIVMKLIRQFVLKNQSTTSNSE--NALMLLYEKCSL 167

  Fly   220 TKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLI 284
            ...::.|..|                             ||                       :
Worm   168 RYRMENRHQE-----------------------------TE-----------------------V 180

  Fly   285 IGFDVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESE 349
            |..:||     ..|.:|. ..|..|.    |.:.||..|..:
Worm   181 IQREVF-----ENIRKIG-SWPIADK----NWNSSHFNLNNM----------------------- 212

  Fly   350 EEEAAKQTSTGMTAYLHYVRKVIEKY-------LLYVDP-----NVNQEEATLGITELVK-QGV- 400
               .:...|..|..:..:..:|||.|       .|.:.|     ::.|||....|.:|:. .|:
Worm   213 ---LSNMASIHMLPFGLFETRVIELYPMNTTAKQLVIRPTKLKFSIPQEELVRAIRDLLSVNGIT 274

  Fly   401 RVARKVHEFKEEAENMTK--------PSKNPADDIVYITLQDLQNQTDKNIAPKTLPIWVRYMEL 457
            .:.:||.|...|:..:.|        |...||      ||.:||         |.:|. :.: |.
Worm   275 SIMKKVKEDVAESFALDKEIGNIHIDPQPKPA------TLSELQ---------KAVPD-IDF-ER 322

  Fly   458 ILKG--TRHAGNIQMTQNLTIITSQADITY--LQNIVEYLDDTPASHIESYLFLSTIEELVLHTS 518
            |:|.  ....||....:. .|.:::.::.:  ..|:...:..|....:.:||||..||.......
Worm   323 IIKSYLNPKTGNWSSLRT-KIFSARFELFFGKNNNLSSIIARTKPRILANYLFLKYIEYAYFFFF 386

  Fly   519 SSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRR 583
            .:.::...:.               :|...|.:.|..|...|.....|.||.:.....::..::.
Worm   387 DNTKVFSDDD---------------FCTEVVTTSLPRASLRVFVRNHFKKENMAVASEIVEVVKT 436

  Fly   584 SFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNAST--------- 639
            ::..::.:::|:..:|:...|:|..:||..||:.........|:..:|..:::.|.
Worm   437 AYVEIINNSTWLHNSTRESAIEKVVKMKKVIGYTEEYERTGALDEMFETLQLSRSDSFFVLMTKV 501

  Fly   640 ---HLENLMDFVHWQMMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL 701
               .:|.|||||   ..|.|  ::..||:..|      |||:....|.:.|.:..|..|.:|...
Worm   502 NRFKIEQLMDFV---SSDSL--LNPIEPLVMA------NAFYFPTKNLLNVLVPFLDKPLFDFKY 555

  Fly   702 -EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADI 765
             ..:....:|.:|.||:.|.||.:||:.|..|...:||:....:||..|:|||.||::.:.....
Worm   556 PRYVAMAGVGRVLAHEIGHAFDINGRQTDEIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSF 620

  Fly   766 DEYIDGELTLGENIADNGGMREAFYAYRLYVKEVG-RERSKLPGLEHYSHEQLFFISFGNLWCET 829
            ....:|...|.|.|||..||..::.|:    |::. .|...|...|.:...:|:|......:|
Worm   621 KGKQNGTEVLAEIIADALGMEASWIAF----KKINLTEEQGLIQFEDHDFGKLYFQVAALDFC-- 679

  Fly   830 YTPA--ASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKC 879
             .|:  ..||:...||...:.|:.|..|||..||.|:||..|:.|||.| :|
Worm   680 -APSRIEERYSDQLSHPTNKFRINGAFSNSRAFADTYKCPVGSKMNPVQ-RC 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	177/777 (23%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	177/772 (23%)
nep-13	NP_001342017.1	M13	104..729	CDD:189000	176/771 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920