Protein Alignment Nep5 and Ecel1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_067281.2
• Gene: Ecel1 / 13599
• MGIID: 1343461
• Length: 775
• Species: Mus musculus
• Alignment Length: 855
• Identity: 222/855 - (25%)
• Similarity: 363/855 - (42%)
• Gaps: 144/855 - (16%)

  Fly    68 TESANGKQLPYEPISPNLIGIQSKFRRSYYHK------VVLGGL-----LALVIILLIAIIVISL 121
            |..|.|..||  |..|...|..:...||...:      .:|.||     |..::..::|:..:..
Mouse    25 TGGARGTSLP--PGFPRGSGRSASGSRSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGP 87

  Fly   122 GLKKSSSIC-----RSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFR 181
            |.......|     ..|...|.|..|...:|...|||:|||.|.||.|...|..||...:....
Mouse    88 GAAGGGGACPEGCPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTI- 151

  Fly   182 ERQAHIMRVVREFLRSNITKSEPEAVG----KAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPV 242
               |.|.....|.||..:.:......|    |.:..:|:|:|.:.:::....|:        |.|
Mouse   152 ---AAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPM--------LEV 205

  Fly   243 LPSALNLTLGSGSKYATEAANVKYNWL----QSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIAL 303
            :.......|| |:.....||....|.|    |.:.|..  ....|.:..|      :|..:|..:
Mouse   206 IEDCGGWDLG-GAADRPGAARWDLNRLLYKAQGVYSAA--ALFSLTVSLD------DRNSSRYVI 261

  Fly   304 GTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYV 368
            ...:.....|              .:|:::              :::||:.|.    :.||..::
Mouse   262 RIDQDGLTLP--------------ERTLYL--------------AQDEESEKI----LAAYRVFM 294

  Fly   369 RKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDI------ 427
            ::::.  ||..|                    .|.:|..|..:..:.:...|.:..||:
Mouse   295 QRLLR--LLGAD--------------------AVEQKAQEILQLEQRLANISVSEYDDLRRDVSS 337

  Fly   428 VY--ITLQDLQNQTDKNIAPKTLP--IWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQN 488
            .|  :||..||         |.:|  .|...::.|.:.       ..::...::....|  |:|.
Mouse   338 AYNKVTLGQLQ---------KIIPHLQWKWLLDQIFQE-------DFSEEEEVVLLATD--YMQQ 384

  Fly   489 IVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLL 553
            :.:.:..||...:.:||....:..|..|.||..|....|..:...|.:.....:..|....|...
Mouse   385 VSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHF 449

  Fly   554 GMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPP 618
            |||:..:.....|:.....||::::.||:....:.::...||||.||.....|...|...:|:|.
Mouse   450 GMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPD 514

  Fly   619 WLRNASVLNAYYEGAEVNASTHLENLMDFVHWQM---MDKL-NEMDKPEPIGWATSPSNVNAFHT 679
            :|.....::..|| .||:..|:.:|:::.:.:.:   :.|: .|:||.   .|...|..:||::.
Mouse   515 FLLKPEAVDKEYE-FEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKS---SWLLPPQALNAYYL 575

  Fly   680 FQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTI 743
            ...|.:..|..|||...||... ::||||.||||:|||||||:||.|.::||:||::.||:..:.
Mouse   576 PNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSY 640

  Fly   744 DEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPG 808
            ..::.:.||.|..|..:.:  .::.::|:.||||||||.||::.|:|||:.:|:|.|.|. .|..
Mouse   641 SHFLRKAECIVRLYDNFTV--YNQRVNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEH-PLHR 702

  Fly   809 LEHYSHEQLFFISFGNLWC-ETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFARTFKCARGTPM 872
            |: |:|.|||||:|...|| :..:.:.....|||.|.|...|:.|.:|..|||.|.|.|.:.:||
Mouse   703 LK-YTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPM 766

  Fly   873 NPDQPKCRIW 882
            ||.. ||.:|
Mouse   767 NPVH-KCSVW 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	198/752 (26%)
Ecel1	NP_067281.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..52		8/23 (35%)
		M13	121..773	CDD:341056	198/753 (26%)