Protein Alignment Nep5 and Nep4

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: XP_061501026.1
• Gene: Nep4 / 1273777
• VectorBaseID: AGAMI1_013990
• Length: 1007
• Species: Anopheles gambiae
• Alignment Length: 869
• Identity: 232/869 - (26%)
• Similarity: 369/869 - (42%)
• Gaps: 220/869 - (25%)

  Fly   132 SKECLRTA--ASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREF 194
            |.|.:|.|  |.:...||...|||:||||:.||.|...:|.|....:.|.|...:..:..|:::.
Mosquito   241 SPESVRAAQVAIMKQYMDPDADPCDDFYQYACGNWDRVNPIPKDKAALDTFELLRESLDLVLKQL 305

  Fly   195 LRS-------------NITKSEP------------------------------------------ 204
            |..             :..:|:|
Mosquito   306 LLEGEPAGLLDVENALSTVRSQPDGTKKSTSTTTTAASAGWPTTTVTGGPAQQQLHRVRKRGRAE 370

  Fly   205 ---------------------------------EAVGKAKTMYRACMDTKLLDKRDLEPLINYLL 236
                                             :|..||:.::.:||:.:|:::|.||||...|.
Mosquito   371 NRNRSGRAVQNKLIIRSAQVKRVRRKRELLINDDAEMKARHLFVSCMNYELIERRGLEPLRTLLH 435

  Fly   237 RF-GLPVL-PSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTIN 299
            .. |.||| |...:              ...::||....::::: ..|::|...|.||
Mosquito   436 SLGGWPVLEPHTWD--------------ESSFDWLNLTAALRRY-NNDVLIVEWVGPD------- 478

  Fly   300 RIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAY 364
                                             ::|||:.....|           |||.|:...
Mosquito   479 ---------------------------------IKNSDENIVQFD-----------QTSLGLPTR 499

  Fly   365 LHYV----RKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVAR-KVHEFKEEAENMTK-PSKNP 423
            .:|:    ||.:|.|..::       ...:|:.::.....|.|. ::.||:.:..|:|. |.:..
Mosquito   500 DYYLQPGNRKYLEAYRQFM-------LEVIGLLDVPADTARQATDEMIEFETQLANITSTPEERN 557

  Fly   424 ADDIVY--ITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQA----- 481
            ....:|  :.|..||.:..:                          |..|..|||:|.:.
Mosquito   558 NVSTLYRKLMLDQLQEEVPQ--------------------------INWTHYLTIVTERPVNGSS 596

  Fly   482 -----DITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPR 541
                 .::|::::||.:|.|....:.:||....:...:.:...........:.....|.|.:.||
Mosquito   597 FVVMFAMSYMRDLVELIDQTEPRIVANYLLWRFVRHRINNLDDRFLGAKQRFSNALFGRERNPPR 661

  Fly   542 SLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQK 606
            ...|...||:.:||||..:.....|.:........|..:::.:|..::..|.|:|.||::...||
Mosquito   662 WKNCVTQVNANMGMAVGAMFVRRYFDENSKRDTLTMTHELQDAFREILGRTGWIDMATRQLAEQK 726

  Fly   607 SAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFV-HWQMMDKLNEMDKP-EPIGWAT 669
            ...|...||:|.::.:...|:|.|...|::...:.||.::.: |.:..|: .::.:| ....|.|
Mosquito   727 VNAMSLRIGYPDFILDPEQLSARYATLEIHPDRYFENTLNVLSHIRRTDQ-EKLGQPVNKTAWHT 790

  Fly   670 SPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGN 733
            :|:.|||:::...|.|..|..|||.|||...| :|:|||.||.::||||||||||.||.|||.||
Mosquito   791 APAVVNAYYSRNKNQIMFPAGILQPPFYHRHLPKAINYGGIGVVIGHELTHGFDDKGRLFDRDGN 855

  Fly   734 MVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYV-K 797
            :..|||:|.|:|:..|..|.||||.||.:|::|..:|||.|.|||||||||:::||.||..:: .
Mosquito   856 LYRWWSDRAIEEFHERAACLVEQYGRYRIAEVDVQLDGENTQGENIADNGGIKQAFLAYSKWLAA 920

  Fly   798 EVGR---ERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSHCPGQMRLRGVLSNSE 858
            :..|   |...|||| :.:..||||::|..:||....|.|:|..| |..|.||:.|:.|.|||||
Mosquito   921 QTDRRVLEAETLPGL-NVTRTQLFFLNFAQIWCGAMRPEATRNKLKTAVHSPGRFRVIGTLSNSE 984

  Fly   859 EFARTFKCARGTPMNPDQPKCRIW 882
            :|||.:.|..|:.||| ..||.:|
Mosquito   985 DFAREYHCPVGSTMNP-PGKCSVW 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	223/844 (26%)
Nep4	XP_061501026.1	None