Protein Alignment Nep5 and EEF1AKMT4-ECE2

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_055508.3
• Gene: EEF1AKMT4-ECE2 / 110599583
• HGNCID: 53615
• Length: 883
• Species: Homo sapiens
• Alignment Length: 856
• Identity: 237/856 - (27%)
• Similarity: 406/856 - (47%)
• Gaps: 158/856 - (18%)

  Fly    68 TESANG--------KQLPYEPISPNLIGIQSKFRRSYYHKVVLGGLLALVIILLIAIIVISLGLK 124
            |.|:.|        .::.::..:..|:|.:::.      ::||.|...|:..||:..:| :||::
Human   145 TVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQL------ELVLAGASLLLAALLLGCLV-ALGVQ 202

  Fly   125 ----KSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDS----VTSNDWFR 181
                .|.|.|.::.|:|.|..::.::|....||||||||:||.|...:|.||.    .|.|..:.
Human   203 YHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWD 267

  Fly   182 ERQAHIMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSA 246
            :.||    :::..|.:....|..||..|.:..|.:|:..:.:::...:||.:.:.:.|
Human   268 QNQA----ILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG------- 321

  Fly   247 LNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSA 311
                          ..|:...|.|                     |.|...:..:|    .|..|
Human   322 --------------GWNITGPWDQ---------------------DNFMEVLKAVA----GTYRA 347

  Fly   312 FPF-------NNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVR 369
            .||       ::..|:..:.::.:..:|:.:.    |...:|.:.|:.        :||||.|:.
Human   348 TPFFTVYISADSKSSNSNVIQVDQSGLFLPSR----DYYLNRTANEKV--------LTAYLDYME 400

  Fly   370 KVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--IT 431
            ::  ..||...|...:|:               .::|.|.:.:..|:|.|.....| :.:|  ::
Human   401 EL--GMLLGGRPTSTREQ---------------MQQVLELEIQLANITVPQDQRRDEEKIYHKMS 448

  Fly   432 LQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDT 496
            :.:||     .:||..  .|:.::..:|      ..::::.:..::....|  |||.:.|.::.|
Human   449 ISELQ-----ALAPSM--DWLEFLSFLL------SPLELSDSEPVVVYGMD--YLQQVSELINRT 498

  Fly   497 PASHIESYLFLSTIEELVLHTSSSM---------RLLHSEYMRVAIGTEGS-TPRSLYCANGVNS 551
            ..|.:.:||    |..||..|:||:         :||.:.|     ||:.| .||...|.:..:.
Human   499 EPSILNNYL----IWNLVQKTTSSLDRRFESAQEKLLETLY-----GTKKSCVPRWQTCISNTDD 554

  Fly   552 LLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGF 616
            .||.|:..:...|.|.::.....|.|:|:||.:|:..:....|||..|::...:|:..:...|||
Human   555 ALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGF 619

  Fly   617 PPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQ---MMDKLNEMDKPEPIGWATSPSNVNAFH 678
            |.::.....|:..|:|.|::..:..:|:::..::.   |.|:|.:  .|....|:.:|..|||::
Human   620 PDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRK--PPSRDQWSMTPQTVNAYY 682

  Fly   679 TFQSNAITVPIAILQYPFYDLG-LEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRT 742
            ....|.|..|..|||.|||... .:|||:|.||.::||||||.|||.||.:|:.||:..||.|.:
Human   683 LPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNES 747

  Fly   743 IDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLP 807
            :..:.|.|.|..|||::|.:.  .|.::|..|||||||||||::.|:.||:.::::.|.|: :||
Human   748 LAAFRNHTACMEEQYNQYQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ-QLP 809

  Fly   808 GLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTP 871
            .:...:| ||||:.|..:||...||.:|...| ||.|.|.:.|:.|.||||.:|.|.|.|..|:|
Human   810 AVGLTNH-QLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSP 873

  Fly   872 MNPDQPKCRIW 882
            |||.| .|.:|
Human   874 MNPGQ-LCEVW 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	214/757 (28%)
EEF1AKMT4-ECE2	NP_055508.3	Methyltransferase-like region. /evidence=ECO:0000305	1..160		3/14 (21%)
		UbiG	48..>128	CDD:441829
		M13	232..881	CDD:341056	214/758 (28%)