DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nep5 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:NP_733186.2 Gene:Nep5 / 43255 FlyBaseID:FBgn0039478 Length:882 Species:Drosophila melanogaster
Sequence 2:NP_055508.3 Gene:EEF1AKMT4-ECE2 / 110599583 HGNCID:53615 Length:883 Species:Homo sapiens


Alignment Length:856 Identity:237/856 - (27%)
Similarity:406/856 - (47%) Gaps:158/856 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 TESANG--------KQLPYEPISPNLIGIQSKFRRSYYHKVVLGGLLALVIILLIAIIVISLGLK 124
            |.|:.|        .::.::..:..|:|.:::.      ::||.|...|:..||:..:| :||::
Human   145 TVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQL------ELVLAGASLLLAALLLGCLV-ALGVQ 202

  Fly   125 ----KSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDS----VTSNDWFR 181
                .|.|.|.::.|:|.|..::.::|....||||||||:||.|...:|.||.    .|.|..:.
Human   203 YHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWD 267

  Fly   182 ERQAHIMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSA 246
            :.||    :::..|.:....|..||..|.:..|.:|:..:.:::...:||.:.:.:.|       
Human   268 QNQA----ILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIG------- 321

  Fly   247 LNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSA 311
                          ..|:...|.|                     |.|...:..:|    .|..|
Human   322 --------------GWNITGPWDQ---------------------DNFMEVLKAVA----GTYRA 347

  Fly   312 FPF-------NNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVR 369
            .||       ::..|:..:.::.:..:|:.:.    |...:|.:.|:.        :||||.|:.
Human   348 TPFFTVYISADSKSSNSNVIQVDQSGLFLPSR----DYYLNRTANEKV--------LTAYLDYME 400

  Fly   370 KVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--IT 431
            ::  ..||...|...:|:               .::|.|.:.:..|:|.|.....| :.:|  ::
Human   401 EL--GMLLGGRPTSTREQ---------------MQQVLELEIQLANITVPQDQRRDEEKIYHKMS 448

  Fly   432 LQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDT 496
            :.:||     .:||..  .|:.::..:|      ..::::.:..::....|  |||.:.|.::.|
Human   449 ISELQ-----ALAPSM--DWLEFLSFLL------SPLELSDSEPVVVYGMD--YLQQVSELINRT 498

  Fly   497 PASHIESYLFLSTIEELVLHTSSSM---------RLLHSEYMRVAIGTEGS-TPRSLYCANGVNS 551
            ..|.:.:||    |..||..|:||:         :||.:.|     ||:.| .||...|.:..:.
Human   499 EPSILNNYL----IWNLVQKTTSSLDRRFESAQEKLLETLY-----GTKKSCVPRWQTCISNTDD 554

  Fly   552 LLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGF 616
            .||.|:..:...|.|.::.....|.|:|:||.:|:..:....|||..|::...:|:..:...|||
Human   555 ALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGF 619

  Fly   617 PPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQ---MMDKLNEMDKPEPIGWATSPSNVNAFH 678
            |.::.....|:..|:|.|::..:..:|:::..::.   |.|:|.:  .|....|:.:|..|||::
Human   620 PDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRK--PPSRDQWSMTPQTVNAYY 682

  Fly   679 TFQSNAITVPIAILQYPFYDLG-LEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRT 742
            ....|.|..|..|||.|||... .:|||:|.||.::||||||.|||.||.:|:.||:..||.|.:
Human   683 LPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNES 747

  Fly   743 IDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLP 807
            :..:.|.|.|..|||::|.:.  .|.::|..|||||||||||::.|:.||:.::::.|.|: :||
Human   748 LAAFRNHTACMEEQYNQYQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ-QLP 809

  Fly   808 GLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTP 871
            .:...:| ||||:.|..:||...||.:|...| ||.|.|.:.|:.|.||||.:|.|.|.|..|:|
Human   810 AVGLTNH-QLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSP 873

  Fly   872 MNPDQPKCRIW 882
            |||.| .|.:|
Human   874 MNPGQ-LCEVW 883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nep5NP_733186.2 PepO 146..882 CDD:226118 216/764 (28%)
M13 151..880 CDD:189000 214/757 (28%)
EEF1AKMT4-ECE2NP_055508.3 Methyltransferase-like region. /evidence=ECO:0000305 1..160 3/14 (21%)
Methyltransf_25 62..>128 CDD:316196
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:P0DPD7 88..89
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:P0DPD7 113..114
M13 232..881 CDD:189000 214/758 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D282463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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