Protein Alignment Nep5 and Ece2

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 831
• Identity: 233/831 - (28%)
• Similarity: 397/831 - (47%)
• Gaps: 144/831 - (17%)

  Fly    86 IGIQSKFRRSY-YH---KVVLGGL-LALVIILLIAIIVISLGLKKSSSICRSKECLRTAASLIYA 145
            :|.|.:.|:.: .|   ::||.|| |.|..:||..::.:.:....:.|.|.::.|:|.|..::.:
Mouse    43 VGFQKRTRQLFGSHTQLELVLAGLILVLAALLLGCLVALWVHRDPAHSTCVTEACIRVAGKILES 107

  Fly   146 MDEQTDPCEDFYQFTCGRWANEHPRPDS----VTSNDWFRERQAHIMRVVREFLRSNITKSEPEA 206
            :|....||:|||||:||.|...:|.|:.    .|.|..:.:.||    :::..|.:....|..||
Mouse   108 LDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQA----ILKHLLENTTFNSSSEA 168

  Fly   207 VGKAKTMYRACMDTKLLDKRDLEPLINYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQS 271
            ..|.::.|.:|:.::.::|...:||.:.:.:.|                     ..|:...|.:
Mouse   169 ERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIG---------------------GWNITGPWDE- 211

  Fly   272 IVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPETDSAFPF-------NNDDSHKMLRKIHRK 329
                                |.|...:..:|    .|..|.||       ::..|:..:.::.:.
Mouse   212 --------------------DSFMDVLKAVA----GTYRATPFFTVYVSADSKSSNSNIIQVDQS 252

  Fly   330 TIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITE 394
            .:|:.:.    |...:|.:.|:.        :||||.|:.::  ..||...|...:|:
Mouse   253 GLFLPSR----DYYLNRTANEKV--------LTAYLDYMVEL--GVLLGGQPTSTREQ------- 296

  Fly   395 LVKQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQTDKNIAPKTLPIWVRYME 456
                    .::|.|.:.:..|:|.|.....| :.:|  :::.:||     .:||..  .|:.::.
Mouse   297 --------MQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-----ALAPAV--DWLEFLS 346

  Fly   457 LILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSM 521
            .:|      ..:::..:..::....:  |||.:.|.::.|..|.:.:||    |..||..|:||:
Mouse   347 FLL------SPLELGDSEPVVVYGTE--YLQQVSELINRTEPSILNNYL----IWNLVQKTTSSL 399

  Fly   522 ---------RLLHSEYMRVAIGTEGS-TPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVER 576
                     :||.:.|     ||:.| |||...|.:..:..||.|:..:...|.|.::.....|.
Mouse   400 DQRFETAQEKLLETLY-----GTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEG 459

  Fly   577 MLSDIRRSFDRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHL 641
            |:::||.:|:..:....|||..|:....:|:..:...||||.::.....|:..|:|.||:..:..
Mouse   460 MINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFF 524

  Fly   642 ENLMDFVHWQ---MMDKLNEMDKPEPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLG-LE 702
            :|:::..::.   |.|:|.:  .|....|:.:|..|||::....|.|..|..|||.|||... .:
Mouse   525 QNMLNLYNFSAKVMADQLRK--PPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPK 587

  Fly   703 ALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDE 767
            |||:|.||.::||||||.|||.||.:|:.||:..||.|.::..:.|.|.|..||||:|.:.  .|
Mouse   588 ALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVN--GE 650

  Fly   768 YIDGELTLGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTP 832
            .::|..|||||||||||::.|:.||:.::::.|.|: .||.:...:| ||||:.|..:||...||
Mouse   651 RLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEEQ-PLPAVGLTNH-QLFFVGFAQVWCSVRTP 713

  Fly   833 AASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
            .:|...| ||.|.|.:.|:.|.||||.:|.|.|.|..|:||||.| .|.:|
Mouse   714 ESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQ-LCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	213/757 (28%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	213/758 (28%)