DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep5 and mme

DIOPT Version :9

Sequence 1:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	867	Identity:	250/867 - (28%)
Similarity:	391/867 - (45%)	Gaps:	173/867 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 QNSATESANGKQLPYEPISPNLIGIQSKFRRSYYHKVVLGGLLALVIIL-LIAIIVISLGLKKSS 127
            |.|.|||         .:.|.|..::.             ||:.|.|.| :|:|.:|......:.
Frog     5 QFSTTES---------KMKPGLSPLEK-------------GLIILCIFLGIISIAMILAYATSND 47

  Fly   128 SICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVR 192
            .||.|:.|:.|||.:|..||..||||.||||:.||.|..::..||:...::.|...:..|..|::
Frog    48 GICTSQACISTAARIIANMDAATDPCNDFYQYACGGWLKKNRIPDNNIVSNTFDILRTDIEVVLK 112

  Fly   193 EFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLI--------------NYLLRFGLPVL 243
            :.|........| |:.|.||.|::|:|..:.:.|...|||              |:..|:||  :
Frog   113 DALEKESADDIP-AIKKVKTFYKSCIDETIKNLRKGGPLIKTLPALYDWPIAVDNWETRYGL--V 174

  Fly   244 PSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRT-----INRIAL 303
            .||.....|..:||....                      :|...|..|..|.:     |::..|
Frog   175 WSAQESIAGFITKYGQSG----------------------LINVYVSEDLTNSSTYILHIDQPGL 217

  Fly   304 GTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYV 368
            |.|                             |.|..|.:              .|...|.|.|:
Frog   218 GLP-----------------------------SKDYYDCK--------------GTSEIACLAYM 239

  Fly   369 RKVIEKYLLYVDPNVNQEEATLGITE--LVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYIT 431
            .:::...:|.      ::|..|.|.|  ::.:..:|      ||.|.|    .:|..|.:.:...
Frog   240 EQMVSVAMLI------RKERNLTINEDKILSEMEKV------FKLERE----IAKAEASEEIREN 288

  Fly   432 LQDLQNQTDKNIAPKTLPI--------WVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQN 488
            |.|:..:...:...||.|:        |::.:..|:.    .|.:.:.:|..:....:|  ||:.
Frog   289 LNDIYKKMTLSGIAKTYPLKMNDQNINWLKLINAIIS----PGGVSIEENEQVALICSD--YLKK 347

  Fly   489 IVEYLDDTPASHIESYL----FLSTIEELVL-HTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANG 548
            : .:|:...|..:::||    .||.|.:|.| :.::.:.|..:.|...|.|::..|     |...
Frog   348 L-RFLNKYKARELQNYLGWRYILSAINDLSLEYKNTGIHLKKALYGNAAEGSDWQT-----CVTY 406

  Fly   549 VNSLLGMAVSYVL------ADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKS 607
            :|..:..|:..:.      ||.:..|.| .||:.::::|||:|..:::...|||..||::..:|.
Frog   407 LNDNMEDAIGRLYLKETLSADIEHVKVK-DKVKEIIAEIRRAFLEMLEEMDWMDEDTKKRAARKV 470

  Fly   608 AEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLEN---LMDFVHWQMMDKL-NEMDKPEPIGWA 668
            |.:...|.|...:.:...||..|...|.......||   .::||..:|..:| .:::|.|   |.
Frog   471 ASINERIAFSEDIMDDFKLNEGYSELEFRVDELFENKQKYIEFVQKKMTSRLRKQVNKNE---WV 532

  Fly   669 TSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAG 732
            ..|::||||::...|.|..|..|||.||:.... .|||||.||.|:|||:|||||:.|..||..|
Frog   533 PGPAHVNAFYSLTYNEIVFPAGILQTPFFSSSQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHG 597

  Fly   733 NMVEWWSNRTIDEYVNRTECFVEQYSRYHLADI-DEYIDGELTLGENIADNGGMREAFYAYRLYV 796
            |:|.||:|.::..:.|.::|||.||..|...:. .:|::|..||||||:||||:|.|:.|::.||
Frog   598 NLVNWWTNASMMNFSNLSQCFVNQYGNYSWDEAGGQYLNGISTLGENISDNGGIRGAYRAFKNYV 662

  Fly   797 KEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPA-ASRYALTDSHCPGQMRLRGVLSNSEEF 860
            |. .:|...|||:: ...:||||||||.:||..:.|. |:....|.||.||..|:.|.|.||.||
Frog   663 KS-HKEDDLLPGID-LDSDQLFFISFGQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEF 725

  Fly   861 ARTFKCARGTPMNPDQPKCRIW 882
            ::.|.|.....||| ..||::|
Frog   726 SKAFSCCNNAYMNP-AVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	PepO	146..882	CDD:226118	226/782 (29%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	222/775 (29%)
mme	XP_031758820.1	M13	71..744	CDD:341056	222/775 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020