Protein Alignment Nep5 and ecel1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: XP_012818808.2
• Gene: ecel1 / 100496473
• XenbaseID: XB-GENE-989944
• Length: 764
• Species: Xenopus tropicalis
• Alignment Length: 865
• Identity: 221/865 - (25%)
• Similarity: 375/865 - (43%)
• Gaps: 160/865 - (18%)

  Fly    54 NGNAT-ANGHGQNSATESANGKQLPYEPISPNLIGIQSKFRRSYYHKVVLGGL---LALVIILLI 114
            |.::| :||.....:::....|.:|               |.|.....:|.||   :.|.:||..
 Frog    24 NSSSTLSNGFNLQVSSKKQTKKVVP---------------RWSRRETCLLSGLVFAVGLCVILGC 73

  Fly   115 AIIVISLGLKKSSSI---CRSKECLRTAASLI-YAMDEQTDPCEDFYQFTCGRWANEHPRPDS-- 173
            .:::..|.:::....   |:.::....|:..| ..:|....||.|||.|.||.|...|..|:.
 Frog    74 MLVLKYLSMEQDVQCLEGCQERKAFMRASKFITNNIDPTISPCTDFYSFACGGWLRRHGIPEDKL 138

  Fly   174 -----VTSNDWFRERQAH-IMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRDLEPLI 232
                 ....:...|:..| :::.||.       |.:..|..|.|..:::|::.:.:|:....|::
 Frog   139 IYGTIAAIGEQNEEKLEHLLLQPVRR-------KHKGSAERKVKEFFKSCLNMRDIDRLGARPML 196

  Fly   233 NYLLRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRT 297
            ..:...|                                              |:|:..||  ||
 Frog   197 QVIEDCG----------------------------------------------GWDLPEDP--RT 213

  Fly   298 INRIALGTPETDSAFPFNNDDSHKMLRK---IHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTST 359
                         .:.||     ::|.|   ::...:|...:...||....|.....:....|..
 Frog   214 -------------QWDFN-----ELLYKTQGVYSTAVFFSMTVSLDDKNSSRYIIRIDQDGLTLP 260

  Fly   360 GMTAYLHYVR---KVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSK 421
            ..|.||....   ||:|.|.:::...:    :.||:..:.|:    |.::...::...|:|   .
 Frog   261 ERTLYLGQDEESIKVLEAYKVFMQTIL----SLLGVENVQKK----AEEILHLEQHLSNIT---I 314

  Fly   422 NPADDI------VY--ITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIIT 478
            :..||:      :|  :||..||     .|.|..  .|...:..|.    |. |....:.:.::.
 Frog   315 SEFDDMRRDISTMYNKVTLAQLQ-----QITPHL--NWKNLLNRIF----HT-NFPEDEEVVVLA 367

  Fly   479 SQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSL 543
            :.    |:|.:.|.:..||||.:.:|:....:..|..|.|:..|....|..:...|:|.....:.
 Frog   368 TD----YMQKVSEMIRSTPASVLHNYMLWRIVVVLSEHLSTPFRDAIHELSKEMEGSEKQAELTK 428

  Fly   544 YCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSFDRLVKSTSWMDAATKRKTIQKSA 608
            .|....|...|||:..:..:..|:.....||::::.:|:...|..::...|||..||:...:|..
 Frog   429 VCLTQANKHFGMALGALFVEEYFSSSSKAKVQQLVENIKHILDYRLEELDWMDTETKQAAREKLK 493

  Fly   609 EMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKL----NEMDKPEPIGWAT 669
            .|...||:|..|.....::..|| .|||..|:.:|:::.:.:.:...:    .|:||.   .|..
 Frog   494 HMMVMIGYPDVLLQPESMDKEYE-FEVNEKTYFKNILNSIRYSIKMAVRRIRQEVDKS---AWLL 554

  Fly   670 SPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGTILGHELTHGFDDSGRRFDRAGN 733
            .|..:||::....|.:..|..|||...||... ::||||.||||:|||||||:||.|.::|..||
 Frog   555 PPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDANGN 619

  Fly   734 MVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYRLYVKE 798
            .::||:..:..:::.:.||.|:.|..:.:  .::.::|..||||||||.||::.|:|||:.:|::
 Frog   620 PIQWWTEDSYSKFLKKAECIVDLYENFTV--YNQRVNGRTTLGENIADLGGLKLAYYAYQKWVRD 682

  Fly   799 VGRERSKLPGLEHYSHEQLFFISFGNLWC-ETYTPAASRYALTDSHCPGQMRLRGVLSNSEEFAR 862
            .|.|| .||.|: |:|:|||||:|...|| :..:.:.....|||.|.|...|:.|.:|..|||.|
 Frog   683 NGPER-PLPRLK-YTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVMGSVSQFEEFGR 745

  Fly   863 TFKCARGTPMNPDQPKCRIW 882
            .|.|.|.:||||.. ||.:|
 Frog   746 VFHCPRNSPMNPVH-KCSVW 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	200/756 (26%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	200/757 (26%)