Protein Alignment Nep5 and mmel1

DIOPT Version :10

• Sequence 1: NP_733186.2
• Gene: Nep5 / 43255
• FlyBaseID: FBgn0039478
• Length: 882
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 824
• Identity: 238/824 - (28%)
• Similarity: 390/824 - (47%)
• Gaps: 144/824 - (17%)

  Fly    99 KVVLGGLLALVIILLIAIIVISLGLKKSSSICRSKECLRTAASLIYAMDEQTDPCEDFYQFTCGR 163
            ::.|..||.|:...::|::|:....|:  |||.:..|:..||.:|..||...:||.||||:.||.
 Frog    46 EIGLSVLLFLMTCAVVALLVLYTSHKE--SICTTTGCVTAAARIIQNMDPTIEPCTDFYQYACGG 108

  Fly   164 WANEHPRPDSVTSN-----DWFRERQAHIMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLL 223
            |.|:|..|:  ||:     |..|:.    |.::.:.|.....:.:.:|..|||.:|::||:..|:
 Frog   109 WLNKHVIPE--TSSRYSIFDILRDE----MEIILKGLLEMPDQEDRDAFKKAKILYKSCMNESLI 167

  Fly   224 DKRDLEPLINYLLRFG-LPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGF 287
            ::||..||:..|...| .||..:..|     |:|        :.||     |:::.|::
 Frog   168 EQRDSLPLLELLTTVGEWPVASTDWN-----GTK--------ESNW-----SLEEKLSL------ 208

  Fly   288 DVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEE 352
                  .|...|:..|                         ..||:.|        |||||.:..
 Frog   209 ------LNYKFNKRVL-------------------------VDIFVWN--------DDRESSKHI 234

  Fly   353 A-AKQTSTGMTAYLHYVRK-----VIEKYLLYV---------------DPNVNQEEATLGITELV 396
            . ..|.|.||.:..:|..|     :.|.||.::               |.::.|||.|
 Frog   235 IYIDQPSLGMPSRDYYFNKGNYQRIREAYLQFMITIARMVREDRNLTRDDSLVQEEMT------- 292

  Fly   397 KQGVRVARKVHEFKEEAENMTKPSKNPAD-DIVY--ITLQDLQNQ---TDKNIAPKTLPIWVRYM 455
                    :|.:.:.:....|.||:...| .::|  :||.:.|.:   .|.|        |..:
 Frog   293 --------RVMDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDFN--------WTSF- 340

  Fly   456 ELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIESYLFLSTIEELVLHTSSS 520
               ::|...:.|||:.....::...|  .||..:...|.:..||.:::|:....:.:.|...|..
 Frog   341 ---IQGVMSSVNIQLQAEEEVVVYGA--PYLHQLKNILSNYSASTLQNYVVWRMVIDRVSSLSRR 400

  Fly   521 MRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSF 585
            .:...:.|.:...||.....|...|.:.|||.:..||..:.....|..|....:..:::.:|.:|
 Frog   401 YKDARASYRKALYGTTLEEARWRECVSYVNSNMENAVGAMYVKETFAGESKRMISDLINKVREAF 465

  Fly   586 DRLVKSTSWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNAS--THLENLMDFV 648
            ...:....|||..:|.|..:|:..:|..||:|.::..........|.|.:|.|  .:.||:::.:
 Frog   466 IETLDELQWMDETSKDKAREKALSIKEQIGYPDYILEDQNDKLDQETAALNFSEYQYFENILEIL 530

  Fly   649 HWQMMDKLNEMDKP-EPIGWATSPSNVNAFHTFQSNAITVPIAILQYPFYDLGL-EALNYGSIGT 711
            :......|.::.:| :...|....:..:||::...|.|..|..|||.||::... :|||:|.||.
 Frog   531 NSGAQKSLKKLREPVDQDAWIIGAAVADAFYSPNRNQIVFPAGILQPPFFNKHQPQALNFGGIGM 595

  Fly   712 ILGHELTHGFDDSGRRFDRAGNMVEWWSNRTIDEYVNRTECFVEQYSRY--HLADIDEYIDGELT 774
            ::|||:||||||:||.||:.|||.:||||.:...:.:::.|.|.||..|  .||. .:.:.|.:|
 Frog   596 VIGHEITHGFDDNGRNFDKDGNMFDWWSNFSAMHFKDQSRCMVYQYGNYTWELAG-GQNVSGIIT 659

  Fly   775 LGENIADNGGMREAFYAYRLYVKEVGRERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL 839
            ||||||||||:|:|:.||..:|:..|:| .|||||: .:::||||::|..:||.:|.|..:|:::
 Frog   660 LGENIADNGGVRQAYKAYLKWVERHGKE-PKLPGLD-LTYKQLFFLNFAQVWCGSYRPEYARHSI 722

  Fly   840 -TDSHCPGQMRLRGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882
             ||.|.|.:.|:.|.|.|.|.||..|.|.:||.|:|.: |||:|
 Frog   723 KTDVHSPFKYRVMGSLQNFEAFAEEFNCKKGTKMHPVE-KCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep5	NP_733186.2	M13	151..880	CDD:341056	219/768 (29%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	219/769 (28%)