DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and qrfpr

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	XP_012820557.1	Gene:	qrfpr / 779748	XenbaseID:	XB-GENE-994316	Length:	456	Species:	Xenopus tropicalis

Alignment Length:	399	Identity:	108/399 - (27%)
Similarity:	189/399 - (47%)	Gaps:	58/399 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 KIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFIL 169
            ||....:.:.||:.||.||..|.|:|..:..||||||.||.|||:.|:|::|||:|.:.:.....
Frog    79 KIAFVTICVLIFVLALFGNSLVLYVVTRSKAMRTVTNIFICSLALSDLLIAFFCIPFTMLQNISS 143

  Fly   170 NYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPR--ITKRYATFIIAGVWFIA 232
            | |..|...|..|.:.|:.:::....|:..|:::|:..|:.|||.:  .|.|.|..::..||.||
Frog   144 N-WLGGAFACKMVPFVQSTAIVTEILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGIVWLIA 207

  Fly   233 LATALPIPIVSGLDIPMSPWHTKC----------EKYI-CREMWPSRTQEYYYTLSLFALQFVVP 286
            ....:|:            ||.:.          ::|: |.|.|.|:..:..||..:..:.|::|
Frog   208 AVVGIPM------------WHAQRLEVKYDFLYEKQYVCCLEAWNSQVHQKIYTTFILVILFLLP 260

  Fly   287 LGVLIFTYARITIRVWAKRPPGEAET------NRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNI 345
            |.|::..|::|...:|.|:..|:|..      :...::||.|::.:.||:|||::|..||.||::
Frog   261 LTVMLLLYSKIGYELWIKKRVGDASVLQTIHGSEMSKIARKKKRAIIMMITVVVLFAVCWAPFHV 325

  Fly   346 LQLLLNDEEFAH-WD--PLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRW 407
            :.:::....|.: :|  .:..::.....:...:...|||:|.:||..|:..|:..:       .:
Frog   326 VHMMIEYSNFENEYDDVTIKIIFAIVQIIGFFNSICNPIVYAFMNENFKKNFLSAL-------CF 383

  Fly   408 CCLR--SVGDRMNATSGEMTTKYHRHVGDALFRKPKICIRNGSSTSSQSNEHI----------HH 460
            |.||  |...|....|| :|....:   .:..|:...|........|:.|..:          .|
Frog   384 CFLRDPSSPSRRPGNSG-ITLIQQK---SSSSRRENTCEDTRREAFSEGNIEVKFFDQPVSKKRH 444

  Fly   461 LHQRSSKAT 469
            ||..:|:.|
Frog   445 LHLFTSELT 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	46/122 (38%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	80/282 (28%)
qrfpr	XP_012820557.1	7tmA_QRFPR	80..377	CDD:320333	89/309 (29%)
		TM helix 1	81..107	CDD:320333	9/25 (36%)
		TM helix 2	114..140	CDD:320333	13/25 (52%)
		TM helix 3	152..182	CDD:320333	6/29 (21%)
		TM helix 4	195..216	CDD:320333	6/32 (19%)
		TM helix 5	245..270	CDD:320333	7/24 (29%)
		TM helix 6	300..330	CDD:320333	12/29 (41%)
		TM helix 7	345..370	CDD:320333	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3897
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940