DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and TACR3

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001050.1	Gene:	TACR3 / 6870	HGNCID:	11528	Length:	465	Species:	Homo sapiens

Alignment Length:	400	Identity:	123/400 - (30%)
Similarity:	198/400 - (49%)	Gaps:	49/400 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 MWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSS 162
            :||.||..::.         .|::||..|.:|:.:..|||||||||:.:||..|..|:.|....:
Human    87 LWSLAYGVVVA---------VAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVN 142

  Fly   163 FISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAG 227
            || ..:.:.|.||...|.|.|:....:|..|.|::.||::|||:||:.|||||::......:|..
Human   143 FI-YALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGS 206

  Fly   228 VWFIALATALPIPIVSGLDIPMSPWHTKCEKYICREMWPSRTQEYY-YTLSLFALQFVVPLGVLI 291
            :|.:|...|.|..:.|...:  .|..|     :|...||...:::: |.:.:..|.:..||.::.
Human   207 IWILAFLLAFPQCLYSKTKV--MPGRT-----LCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMG 264

  Fly   292 FTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLN-DEEF 355
            .||..:.|.:|....||:. .::.....::|||:||||:.||:.|..||||::|..:|.. .::.
Human   265 ITYTIVGITLWGGEIPGDT-CDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQL 328

  Fly   356 AHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVG--DRMN 418
            ..|..:..|:.|..|||||...|||||||.:|.|||:||.:..       |||....|.  |.:.
Human   329 NRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAF-------RWCPFIKVSSYDELE 386

  Fly   419 ATSGEMTTKYHRHVGDALF---RKPKICI---RNGSSTSSQSNE--------HIHHLHQRSSKAT 469
            .    .||::|.:...:::   |...:.:   .|.:.|:..|.:        ..:...:|:||:.
Human   387 L----KTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSA 447

  Fly   470 S--DIFASEP 477
            |  ..|.|.|
Human   448 SATSSFISSP 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	45/120 (38%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	90/262 (34%)
TACR3	NP_001050.1	7tmA_NKR_NK3R	86..367	CDD:320669	102/297 (34%)
		TM helix 1	87..113	CDD:320669	9/34 (26%)
		TM helix 2	120..146	CDD:320669	11/26 (42%)
		TM helix 3	158..188	CDD:320669	12/29 (41%)
		TM helix 4	199..220	CDD:320669	5/20 (25%)
		TM helix 5	244..273	CDD:320669	6/28 (21%)
		TM helix 6	292..322	CDD:320669	15/29 (52%)
		TM helix 7	335..360	CDD:320669	14/24 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..465		9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920