DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and NPY2R

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_000901.1	Gene:	NPY2R / 4887	HGNCID:	7957	Length:	381	Species:	Homo sapiens

Alignment Length:	366	Identity:	112/366 - (30%)
Similarity:	179/366 - (48%)	Gaps:	52/366 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 KIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFIL 169
            ::::.:.|..|.:..:|||..|.::|.....||||||:|||:||:.|:|::..|:|      |.|
Human    50 QVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLP------FTL 108

  Fly   170 NY-----WPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVW 229
            .|     |..|..|||.|.|:|.::|.||..||..|::||:..|::.|:.:|:||.:..||...|
Human   109 TYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAW 173

  Fly   230 FIALATALPIPIVSGLD-IPMSPWHTKCEKYICREMWPSRTQEYY---YTLSLFALQFVVPLGVL 290
            .|:...|.|:.|..... |.:.|   ..|...|.|.||...:..|   |:||...:.:|:|||::
Human   174 GISALLASPLAIFREYSLIEIIP---DFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGII 235

  Fly   291 IFTYARITIRVWAKR----PPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNILQLLLN 351
            .|:|.||    |:|.    .||.|..:..||    ::|..||::.||:||...|||.:..||.::
Human   236 SFSYTRI----WSKLKNHVSPGAANDHYHQR----RQKTTKMLVCVVVVFAVSWLPLHAFQLAVD 292

  Fly   352 -DEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLRSVGD 415
             |.:.........::..||.:||.....||::|.:||:.:|..|         |..:.|    ..
Human   293 IDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF---------LSAFRC----EQ 344

  Fly   416 RMNATSGEMTTKYHRHVGDALFRKPKICIRNGSSTSSQSNE 456
            |::|...|::..:.        .|..:.:|..|..:....|
Human   345 RLDAIHSEVSVTFK--------AKKNLEVRKNSGPNDSFTE 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	49/125 (39%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	95/274 (35%)
NPY2R	NP_000901.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		7tmA_NPY2R	51..336	CDD:320521	102/301 (34%)
		TM helix 1	52..78	CDD:320521	7/25 (28%)
		TM helix 2	85..110	CDD:320521	13/30 (43%)
		TM helix 3	123..153	CDD:320521	13/29 (45%)
		TM helix 4	164..185	CDD:320521	6/20 (30%)
		TM helix 5	216..245	CDD:320521	12/32 (38%)
		TM helix 6	261..291	CDD:320521	14/33 (42%)
		TM helix 7	304..329	CDD:320521	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5469
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102619
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760