DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RYa-R and npy7r

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001007219.1	Gene:	npy7r / 449010	ZFINID:	ZDB-GENE-040924-9	Length:	372	Species:	Danio rerio

Alignment Length:	327	Identity:	108/327 - (33%)
Similarity:	177/327 - (54%)	Gaps:	28/327 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TVMMNFSCDDY-DLLSEDMWSSAYFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFI 144
            |.:.|.|.:.| ....:|:......:|.:.:.|..|.:..|:||..|.|::.....|||||||||
Zfish    22 TSLGNDSVNTYKPAFVDDITKHLSVQISLILAYSLIILLGLVGNTLVIYMIILYRNMRTVTNYFI 86

  Fly   145 ASLAIGDILMSFFCVPSSFISLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIM 209
            |:||:.|:::...|:|.:.: ..:|:.|.||..:||.|.||||:||.||..||..|:::||..|:
Zfish    87 ANLALADLMVDTVCLPFTLV-YTLLDEWKFGAVMCHMVPYSQALSVHVSILTLTIIALERYRCIV 150

  Fly   210 WPLKPRITKRYATFIIAGV-WFIALATALPIPI--------VSGLDIPMSPWHTKCEKYICREMW 265
            :.|..|: .|..:|||.|: |..|...|.|:.|        :..:|:.::         :|.|.|
Zfish   151 FHLGQRL-NRCTSFIIIGLTWAFAAILAGPLAIFREYRYEEIPYIDLRIA---------VCSEKW 205

  Fly   266 PSRTQE--YYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKM 328
            |:.|..  ..|:||:..||:||||.::.:.|    :.:|.|.....:.:||:..:.| ::|..||
Zfish   206 PNGTNRDAVIYSLSMLLLQYVVPLAIISYAY----VCIWIKLKNHVSPSNRNDGIVR-RKKTTKM 265

  Fly   329 MLTVVIVFTCCWLPFNILQLLLNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSG 393
            :..||:||..|||||::.||..:.:....:.....::..||.:||.....||::|.:||..:|:|
Zfish   266 LALVVVVFAVCWLPFHMFQLASDLDLILKFKEYKLIYTLFHIVAMCSTFVNPLLYGWMNQNYRNG 330

  Fly   394 FV 395
            |:
Zfish   331 FL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	51/121 (42%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	93/271 (34%)
npy7r	NP_001007219.1	7tm_GPCRs	48..331	CDD:333717	101/298 (34%)
		TM helix 1	50..74	CDD:320095	7/23 (30%)
		TM helix 2	83..105	CDD:320095	10/21 (48%)
		TM helix 3	121..143	CDD:320095	13/21 (62%)
		TM helix 4	164..180	CDD:320095	6/15 (40%)
		TM helix 5	214..237	CDD:320095	10/26 (38%)
		TM helix 6	260..285	CDD:320095	12/24 (50%)
		TM helix 7	299..324	CDD:320095	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3897
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940