DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RYa-R and TkR99D

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001263092.1	Gene:	TkR99D / 43551	FlyBaseID:	FBgn0004622	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	145/496 - (29%)
Similarity:	239/496 - (48%)	Gaps:	72/496 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PASLIYN--TTALPADDEGSNYGYGSTTTLSGLQFETYNITVMMNF-SCDDYDLLSEDMWSSA-- 102
            ||.::::  ::.|.|.:......:|....||...| .::.|:..:. :..|.:..:||..:|.
  Fly    26 PAGVLFSAMSSVLSASNHTPLPDFGQELALSTSSF-NHSQTLSTDLPAVGDVEDAAEDAAASMET 89

  Fly   103 ---------YFKIIVYMLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFC 158
                     :.:::..:|:..:.|.|..||..|.:||.:|.||||||||||.:|:|.|.::|...
  Fly    90 GSFAFVVPWWRQVLWSILFGGMVIVATGGNLIVVWIVMTTKRMRTVTNYFIVNLSIADAMVSSLN 154

  Fly   159 VPSSFISLFILNY-WPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYAT 222
            |  :|...::|:. ||||...|....:...:|:..|.:||:|||||||:||:.||:||::||...
  Fly   155 V--TFNYYYMLDSDWPFGEFYCKLSQFIAMLSICASVFTLMAISIDRYVAIIRPLQPRMSKRCNL 217

  Fly   223 FIIAGVWFIALATALPIPIVSGL-DIPMSPWHTKCEKYICREMWPS-----RTQEYYYTLSLFAL 281
            .|.|.:|..:...:.|:.|:... ::|:   .....:.:|...||.     .|.|..|.:.:..|
  Fly   218 AIAAVIWLASTLISCPMMIIYRTEEVPV---RGLSNRTVCYPEWPDGPTNHSTMESLYNILIIIL 279

  Fly   282 QFVVPLGVLIFTYARITIRVWAKRPPGEAETNRDQRMARSKRKMVKMMLTVVIVFTCCWLPFNIL 346
            .:.:|:..:..||:|:.|.:|..:..||. |.|.....||||::||||:.||::|..|||||:..
  Fly   280 TYFLPIVSMTVTYSRVGIELWGSKTIGEC-TPRQVENVRSKRRVVKMMIVVVLIFAICWLPFHSY 343

  Fly   347 QLL------LNDEEFAHWDPLPYVWFAFHWLAMSHCCYNPIIYCYMNARFRSGFVQLMHRMPGLR 405
            .::      :.:..|     :..::.|.:|||||:..|||||||:||:|||.||..:.
  Fly   344 FIITSCYPAITEAPF-----IQELYLAIYWLAMSNSMYNPIIYCWMNSRFRYGFKMVF------- 396

  Fly   406 RWCCLRSVGDRMNATSGEMTTKYHRHVGDALFRKPKICIRNGSSTSSQSNEHIHHLHQRSSKATS 470
            |||....||....:....:|::|                       |.|....|:..:|:....|
  Fly   397 RWCLFVRVGTEPFSRRENLTSRY-----------------------SCSGSPDHNRIKRNDTQKS 438

  Fly   471 DIFA--SEPIIVRRDVT-TAVAVISKNKTDSPVRRSGSSGG 508
            .::.  |.|...|...: |..:...:|...:....||.|||
  Fly   439 ILYTCPSSPKSHRISHSGTGRSATLRNSLPAESLSSGGSGG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	52/121 (43%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	97/273 (36%)
TkR99D	NP_001263092.1	7tm_4	113..396	CDD:304433	109/293 (37%)
TkR99D	NP_001263092.1	7tm_1	118..381	CDD:278431	97/273 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314830at33208
OrthoFinder	1	1.000	-	-		FOG0000620
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24238
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.020