DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RYa-R and SIFaR

DIOPT Version :9

Sequence 1:	NP_001287552.1	Gene:	RYa-R / 43253	FlyBaseID:	FBgn0004842	Length:	518	Species:	Drosophila melanogaster
Sequence 2:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	163/543 - (30%)
Similarity:	261/543 - (48%)	Gaps:	118/543 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ASLIYNTTALP-----------ADDEGSNYGYG-------STTTL------------SGLQFETY 78
            |:|...|||..           ||...|.| |.       :||:|            |.|::|..
  Fly   126 ATLAATTTASARGSLAGKSLAIADATSSTY-YSNLLNLSPATTSLISAAAATKSYNDSALRWEQL 189

  Fly    79 NITVMMNFSCDDYDLLSEDMWSSAYFKIIVY-MLYIPIFIFALIGNGTVCYIVYSTPRMRTVTNY 142
            :.:|...|         :.::..:....:|| :.||.:|:..||||..|..:|...|||||||||
  Fly   190 DGSVDFGF---------DPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNY 245

  Fly   143 FIASLAIGDILMSFFCVPSSFI-SLFILNYWPFGLALCHFVNYSQAVSVLVSAYTLVAISIDRYI 206
            ||.:|||.|||:..||:|::.| ::|:  .|..|..:|.||.|.|.|||..|.|:|:|:|:||:|
  Fly   246 FIVNLAIADILVIVFCLPATLIGNIFV--PWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFI 308

  Fly   207 AIMWPLKPRITKRYATFIIAGVWFIALATALP-------IP--------IVSGLDIPMSPWHTKC 256
            ||.|||| ::|||.|..:|.|:|.|||.|.:|       :|        :||....|
  Fly   309 AIWWPLK-QMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQP-------- 364

  Fly   257 EKYICREMWPSRTQ-EYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPPGEA-ETNRDQRMA 319
             :::|:|:||..|. ..|:.|:.....:::|:.::...|..|.|:|..:..|||: :...|:...
  Fly   365 -QFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQ 428

  Fly   320 RSKRKMVKMMLTVVIVFTCCWLPFNILQLL------LNDEEFAHWDPLPYVWFAFHWLAMSHCCY 378
            :||.|::||::.|||:|...|||..::...      ::.|||   :.|..|.....||..|:.|.
  Fly   429 KSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEF---EILKKVMPVAQWLGSSNSCI 490

  Fly   379 NPIIYCYMNARFRSGFVQLMHRMPGLRRWCCLR-----SVGDRMNATSGEMTTKYHRHVGDALFR 438
            |||:|. :|.::|.||..::.     .|.||.|     :|....:.||...::.||::..    |
  Fly   491 NPILYS-VNKKYRRGFAAIIK-----SRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSS----R 545

  Fly   439 KPKICIRNGSSTSSQSN------EHIHHLHQRSSKATSDIFASEPIIVRRDVTTAVAVISKNKTD 497
            |         |.||:.|      || :.|.:.:.....|...|:.:::::|...:...:.|.::.
  Fly   546 K---------SPSSKGNAVSYIYEH-NSLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESS 600

  Fly   498 ----SPVRR---SGSSGGTEANI 513
                |.:||   ...|.|::.::
  Fly   601 CSDASGIRRPLCQQDSNGSKVSL 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	63/121 (52%)
RYa-R	NP_001287552.1	7tm_1	122..383	CDD:278431	106/284 (37%)
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	92/238 (39%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	106/284 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8802
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840