Protein Alignment RYa-R and Hcrtr2

DIOPT Version :9

• Sequence 1: NP_001287552.1
• Gene: RYa-R / 43253
• FlyBaseID: FBgn0004842
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_945200.1
• Gene: Hcrtr2 / 387285
• MGIID: 2680765
• Length: 460
• Species: Mus musculus
• Alignment Length: 509
• Identity: 131/509 - (25%)
• Similarity: 214/509 - (42%)
• Gaps: 107/509 - (21%)

  Fly    56 DDEGSNYGYGSTTTLSGLQFETYNITVMMNFSCDDYD-------LLSEDMWSSAYFKIIVYMLYI 113
            :|..|...:.|.:.|:..|....|.|        |||       |..|.:....|..::: ..||
Mouse     7 EDSLSRRNWSSASELNETQEPFLNPT--------DYDDEEFLRYLWREYLHPKEYEWVLI-AGYI 62

  Fly   114 PIFIFALIGNGTVCYIVYSTPRMRTVTNYFIASLAIGDILMSFFCVPSSFISLFILNYWPFGLAL 178
            .:|:.|||||..||..|:....|||||||||.:|::.|:|::..|:|::.: :.|...|.||.:|
Mouse    63 IVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLV-VDITETWFFGQSL 126

  Fly   179 CHFVNYSQAVSVLVSAYTLVAISIDRYIAIMWPLKPRITKRYATFIIAGVWFIALATALPIPIVS 243
            |..:.|.|.|||.||..||..|::||:.||..||..:.|.:.|...|..:|.::....:|..||.
Mouse   127 CKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVM 191

  Fly   244 GLDIPMSPWHTKCEKY-ICREMWPSRTQEYYYTLSLFALQFVVPLGVLIFTYARITIRVWAKRPP 307
            .....:.....|...: :|.|.|........|.:..|.:.::.||.::|..|.:|..::|.::.|
Mouse   192 ECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIP 256

  Fly   308 GEAETNR----------------------------DQRMARSKRKMVKMMLTVVIVFTCCWLPFN 344
            |.:...:                            :.:..|::||..:|::.|::||..|:||.:
Mouse   257 GTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPIS 321

  Fly   345 ILQLL---------LNDEEFAHWDPLPYVWFAF-HWLAMSHCCYNPIIYCYMNARFRSGFVQLMH 399
            ||.:|         ..|.|..      |.||.| |||..::...|||||.:::.:||..|.....
Mouse   322 ILNVLKRVFGMFTHTEDRETV------YAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFS 380

  Fly   400 RMPGLRRWCCLRSVGDRMNATSGEMTTKYHRHVGDALFRKPKICIRNGSSTSSQSNEHIHHLHQR 464
                    |||                ..|...||.|.|         ..||::|.:.:
Mouse   381 --------CCL----------------GVHHRQGDRLAR---------GRTSTESRKSL------ 406

  Fly   465 SSKATSDI--FASEPIIVRRDVTTAVAVISKNKTDSPVRRSGSSGGTEANIRST 516
                |:.|  |.:...:....|.|:::.:.......|::......|..:::.||
Mouse   407 ----TTQISNFDNVSKLSEHVVLTSISTLPAANGAGPLQNWYLQQGVPSSLLST 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RYa-R	NP_001287552.1	7tm_4	113..>234	CDD:304433	50/120 (42%)
		7tm_1	122..383	CDD:278431	87/299 (29%)
Hcrtr2	NP_945200.1	Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614	33..49		5/15 (33%)
		7tm_4	65..>194	CDD:304433	52/129 (40%)
		7tm_1	71..364	CDD:278431	87/299 (29%)
		Orexin_rec2	386..443	CDD:281778	14/75 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8802
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910